[6]-Gingerol, from Zingiber officinale, potentiates GLP-1 mediated glucose-stimulated insulin secretion pathway in pancreatic β-cells and increases RAB8/RAB10-regulated membrane presentation of GLUT4 transporters in skeletal muscle to improve hyperglycemia in Leprdb/db type 2 diabetic mice [PDF]
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give ...
Akhter, Farjana+9 more
core +2 more sources
The growth hormone secretagogue receptor
The specific human growth hormone (GH) secretagogue receptor (type la) was cloned in 1996 using the nonpeptide GH secretagogue MK-0677 as a ligand. 1,2 It belongs to the G-protein coupled seven transmembrane domain receptor family, but does not show close homology with any of the known subgroups of receptors, though its sequence is conserved between ...
KORBONITS M.+3 more
openaire +4 more sources
Quinolones modulate ghrelin receptor signaling: potential for a novel small molecule scaffold in the treatment of cachexia [PDF]
Cachexia is a metabolic wasting disorder characterized by progressive weight loss, muscle atrophy, fatigue, weakness, and appetite loss. Cachexia is associated with almost all major chronic illnesses including cancer, heart failure, obstructive ...
Cano, Rafael+8 more
core +3 more sources
Presynaptic CaV2 voltage‐gated calcium channels link action potentials arriving at the presynaptic terminal to neurotransmitter release. Hence, their regulation is essential to fine tune brain circuitry.
Valentina Martínez Damonte+2 more
semanticscholar +1 more source
Glucocorticoids rapidly inhibit oxytocin-stimulated adrenocorticotropin release from rat anterior pituitary cells, without modifying intracellular calcium transients [PDF]
Glucocorticoid hormones suppress the secretion of ACTH evoked by secretagogues such as CRF and arginine vasopressin. In this study, we investigated the effects of glucocorticoids on ACTH release induced by oxytocin (OT) and on intracellular free calcium ...
Dayanithi, G., Gratzl, Manfred, Link, H.
core +1 more source
Growth Hormone Secretagogue Receptor Dimers: A New Pharmacological Target1,2,3
The growth hormone secretagogue receptor, a key component of the ghrelin system, is important in many processes, including feeding behavior, stress, and reward.
Martin K. Wellman, A. Abizaid
semanticscholar +1 more source
Structural Requirements for the Activation of the Human Growth Hormone Secretagogue Receptor by Peptide and Nonpeptide Secretagogues [PDF]
AbstractAntibodies raised against an intracellular and extracellular domain of the GH secretagogue receptor (GHS-R) confirmed that its topological orientation in the lipid bilayer is as predicted for G protein-coupled receptors with seven transmembrane domains.
JR Tata+14 more
openaire +4 more sources
Structure and Physiological Actions of Ghrelin
Ghrelin is a gastric peptide hormone, discovered as being the endogenous ligand of growth hormone secretagogue receptor. Ghrelin is a 28 amino acid peptide presenting a unique n-octanoylation modification on its serine in position 3, catalyzed by ghrelin
Christine Delporte
doaj +1 more source
Insulin secretagogue use and circulating inflammatory C–C chemokine levels in breast cancer patients
Monocytes’ infiltration into the tumor tissue and their activation to tumor-associated macrophages is an essential step in tumor development, also playing a critical role in an eventual metastasis.
Zachary A.P. Wintrob+6 more
doaj +1 more source
Evaluation and Diagnostic Potential of Serum Ghrelin in Feline Hypersomatotropism and Diabetes Mellitus [PDF]
BACKGROUND: Ghrelin is a growth hormone secretagogue. It is a potent regulator of energy homeostasis. Ghrelin concentration is down‐regulated in humans with hypersomatotropism (HS) and increases after successful treatment. Additionally, ghrelin secretion
Appleton+42 more
core +1 more source