Risk of Hypoglycemia Associated With Concomitant Use of Insulin Secretagogues and ACE Inhibitors in Adults With Type 2 Diabetes: A Systematic Review. [PDF]
Clin Pharmacol TherChu PY +4 more
europepmc +3 more sources
Insulin secretagogue use and circulating inflammatory C–C chemokine levels in breast cancer patients
Data in Brief, 2017 Monocytes’ infiltration into the tumor tissue and their activation to tumor-associated macrophages is an essential step in tumor development, also playing a critical role in an eventual metastasis.
Zachary A.P. Wintrob +6 more
doaj +1 more source
Structure and Physiological Actions of Ghrelin
Scientifica, 2013 Ghrelin is a gastric peptide hormone, discovered as being the endogenous ligand of growth hormone secretagogue receptor. Ghrelin is a 28 amino acid peptide presenting a unique n-octanoylation modification on its serine in position 3, catalyzed by ghrelin
Christine Delporte
doaj +1 more source
The controversial role of the vagus nerve in mediating ghrelin's actions: gut feelings and beyond
IBRO Neuroscience Reports, 2022 Ghrelin is a stomach-derived peptide hormone that acts via the growth hormone secretagogue receptor (GHSR) and displays a plethora of neuroendocrine, metabolic, autonomic and behavioral actions.
Mario Perelló +5 more
doaj +1 more source
Efficacy of rebamipide 2% ophthalmic solution in the treatment of dry eyes
Oman Journal of Ophthalmology, 2018 AIM: The aim of this study is to evaluate the efficacy of 2% rebamipide ophthalmic solution on the tear functions and ocular surface status in patients with dry eyes.
Saurabh Shrivastava +4 more
doaj +1 more source
Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide
Frontiers in Pharmacology, 2022 Mitiglinide is a highly selective fast-acting anti-diabetic drug that induces insulin secretion by inhibiting pancreatic KATP channels. However, how mitiglinide binds KATP channels remains unknown.
Mengmeng Wang +9 more
doaj +1 more source
Food and the brain: Neural and endocrine control of feeding, metabolism, and reproduction. [PDF]
J NeuroendocrinolAbstract Feeding and reproductive function are regulated by intricate systems that monitor food availability and energy stores, and on the basis of energy status, promote or put a brake on reproduction. This is particularly evident in the systems that regulate feeding and reproductive state in female mammals.
da Silva Mansano N, Lieu CV, Abizaid A.
europepmc +2 more sources
Pharmacogenetics of insulin secretagogue antidiabetics [PDF]
Orvosi Hetilap, 2011 Type 2 diabetes is making up to 90% of the all diabetic cases. In addition to insulin resistance, insufficient B-cell function also plays an important role in the pathogenesis of the disease. The insufficient production and secretion of insulin can be increased by secretagogue drugs, like sulfonylureas and incretin mimetics/enhancers.
Gábor, Winkler, László, Gerô
openaire +2 more sources
Biological, Physiological, and Pharmacological Aspects of Ghrelin
Journal of Pharmacological Sciences, 2006 .: Ghrelin, identified as an endogenous ligand for the growth hormone secretagogue receptor, functions as a somatotrophic and orexigenic signal from the stomach.
Hiroshi Hosoda +2 more
doaj +1 more source
The Structural Basis for the Binding of Repaglinide to the Pancreatic KATP Channel
Cell Reports, 2019 Summary: Repaglinide (RPG) is a short-acting insulin secretagogue widely prescribed for the treatment of type 2 diabetes. It boosts insulin secretion by inhibiting the pancreatic ATP-sensitive potassium channel (KATP).
Dian Ding +4 more
doaj +1 more source