Results 41 to 50 of about 15,945 (227)
Diagnostics, 2020 Anti-glaucoma eye drop treatment often induces dry eyes and can lead to poor medication adherence. This study aimed to investigate the effects of 3% diquafosol sodium eye drops on tear function and the ocular surface epithelium in Sod1−/− ...
Yukari Yagi-Yaguchi +7 more
doaj +1 more source
Cells, 2019 Steroidal anti-inflammatory drugs are widely used for the treatment of chronic cutaneous inflammation, such as atopic dermatitis, although it remains unknown how they modulate cutaneous mast cell functions.
Keiko Yamada +7 more
doaj +1 more source
Nutrition in Clinical Practice, EarlyView.Abstract Background Plasma amino acid (AA) profiles in parenteral nutrition (PN)–dependent very preterm infants (VPIs) consistently show overprovision of essential AA (EAA) and arginine deficiency. This may have implications for growth and immune/inflammatory responses.
Frances Callaghan +6 more
wiley +1 more source
Biochemistry and Biophysics Reports, 2016 Background: Growth hormone secretagogues (GHS), among other factors, regulate the release of GH. The biological activity of the secretagogue peptide A233 as a promoter of growth and innate immunity in teleost fish has previously been demonstrated, but ...
Rebeca Martínez +17 more
doaj +1 more source
Slow Transit Constipation: Pathophysiological Perspectives and Management Updates
Journal of Digestive Diseases, EarlyView.Slow transit constipation (STC) is a complex neuromuscular disorder driven by interstitial cells of Cajal (ICCs) loss and enteric neuropathy. Diagnosis relies on objective transit testing while excluding pelvic floor dysfunction. Management follows a stepwise, phenotype‐driven approach, progressing from conventional laxatives to emerging targeted ...
Athanasios Syllaios +8 more
wiley +1 more source
Alimentary Pharmacology &Therapeutics, EarlyView.Serum villin‐1 is a non‐invasive indicator of gut barrier damage and short‐term mortality in acutely decompensated cirrhosis. Incorporating villin‐1 assessment into risk stratification methods improves prognostic accuracy by capturing an essential, yet previously overlooked component of disease progression.
David Tornai +22 more
wiley +1 more source
Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism
Cell Reports, 2015 Pancreatic islet failure, involving loss of glucose-stimulated insulin secretion (GSIS) from islet β cells, heralds the onset of type 2 diabetes (T2D). To search for mediators of GSIS, we performed metabolomics profiling of the insulinoma cell line 832 ...
Jessica R. Gooding +8 more
doaj +1 more source
Correction: A Novel Diphenylthiosemicarbazide Is a Potential Insulin Secretagogue for Anti-Diabetic Agent. [PDF]
PLoS ONE, 2017 [This corrects the article DOI: 10.1371/journal.pone.0164785.].
PLOS ONE Staff
doaj +1 more source
Dual action of imeglimin on insulin secretion and sensitivity in type 2 diabetes
Diabetes, Obesity and Metabolism, EarlyView.Abstract Aims Imeglimin is a novel oral hypoglycemic agent approved for the treatment of type 2 diabetes in Japan, with dual actions to enhance insulin secretion and improve insulin sensitivity, suggested by preclinical evidence. However, the effect of imeglimin on tissue‐specific insulin sensitivity and glucose kinetics using glucose tracers is ...
Tsubasa Tajima +10 more
wiley +1 more source
Neurogastroenterology &Motility, EarlyView.Our study showed that, in healthy controls, acute administration of linaclotide increased the total number of long‐distance propagating and the pre‐prandial pancolonic pressurizations. Further studies need to address whether the observed effects are directly or indirectly mediated by the mechanism of action of this useful medication to treat chronic ...
Christian Lambiase +7 more
wiley +1 more source