Results 51 to 60 of about 34,073 (255)

Calcium-sensing receptor activation increases cell-cell adhesion and ß-cell function [PDF]

, 2012
Background/Aims: The extracellular calcium-sensing receptor (CaR) is expressed in pancreatic β-cells where it is thought to facilitate cell-to-cell communication and augment insulin secretion.
Bennett, J., Hills, C. E., Liu, K.-K., Siamantouras, E., Squires, P. E., Younis, M. Y.G.   +5 more
core   +2 more sources

Correction: A Novel Diphenylthiosemicarbazide Is a Potential Insulin Secretagogue for Anti-Diabetic Agent. [PDF]

PLoS ONE, 2017
[This corrects the article DOI: 10.1371/journal.pone.0164785.].
PLOS ONE Staff
doaj   +1 more source

Abstract Conformer Space

Helvetica Chimica Acta, Accepted Article.
Pairwise distance root mean square deviation defines a hyperspace where conformers with similar shape reside close to each other. The radius of gyration of protein ensembles in this abstract conformer space (ACS) converges at ensemble sizes between 50 and 500, depending on the extent of disorder.
Gunnar Jeschke
wiley   +1 more source

Role of Peptide Backbone Conformation on Biological Activity of Chemotactic Peptides [PDF]

, 1991
To investigate the role of peptide backbone conformation on the biological activity of chemotactic peptides, we synthesized a unique analog of N-formyl-Met-Leu-Phe-OH incorporating the C α,α disubstituted residue, dipropylglycine (Dpg) in place of Leu ...
Bhandary, Krishna K., Dentino, Andrew R., Devine, Michael J., Raj, Periathamby A., Wilson, Mark E.   +4 more
core   +1 more source

Snapin mediates insulin secretory granule docking, but not trans-SNARE complex formation [PDF]

, 2016
Secretory granule exocytosis is a tightly regulated process requiring granule targeting, tethering, priming, and membrane fusion. At the heart of this process is the SNARE complex, which drives fusion through a coiled-coil zippering effect mediated by ...
Aganna, Aran, Bratanova-Tochkova, Burkhardt, Buxton, Catriona Marshall, Christopher J. Partridge, Hilfiker, Ilardi, Lupas, Mark D. Turner, Marshall, Navarro, Oh, Pan, Sangeeta Somanath, Song, Thurmond, Tian, Tony Rowe, Varadi, Varadi, Weber, Yu   +23 more
core   +1 more source

Comparative proteomic analysis of growth hormone secretagogue A233 treatment of murine macrophage cells J774A.2 indicates it has a role in antiviral innate response

Biochemistry and Biophysics Reports, 2016
Background: Growth hormone secretagogues (GHS), among other factors, regulate the release of GH. The biological activity of the secretagogue peptide A233 as a promoter of growth and innate immunity in teleost fish has previously been demonstrated, but ...
Rebeca Martínez, Teresa Núñez de Villavicencio-Díaz, Aniel Sánchez, Yassel Ramos, Jesús Noda Ferro, Lázaro Gil González, Milagros Méndez, Elsa Rodríguez, Ernesto Marcos, Belinda Sánchez, Yordanka Masforrol, Hilda Garay, Fernando Albericio, Lisset Hermida, Luis Javier González, Eva Vonasek, Mario P Estrada, Vladimir Besada   +17 more
doaj   +1 more source

Critical mistakes in managing chronic constipation in the older person and how to avoid them: A narrative review

Journal of General and Family Medicine, EarlyView.
Abstract Objectives This narrative review identifies pitfalls in managing constipation in older adults and provides evidence‐based recommendations to avoid them. Methods A selective literature search was conducted across electronic databases (PubMed, MEDLINE, Embase, and Cochrane Library) to identify relevant publications on constipation management in ...
Madunil Niriella, Hiruni Jayasena, Prathibha Wijesingha, Janaka de Silva   +3 more
wiley   +1 more source

Measurement of the Proteinase Inhibitors of the Bovine Pancreas by Radioimmunoassay [PDF]

, 1976
Bovine pancreas contains two polypeptide trypsin inhibitors that are not homologous and differ in their inhibitory activity towards chymotrypsin, kallikrein, elastase, and other serine proteinases. The Kunitz inhibitor and the Kazal inhibitor are present
Fink, Edwin, Greene, Lewis J., Peeters, H.   +2 more
core   +1 more source

TH1 and TH2 cytokine data in insulin secretagogues users newly diagnosed with breast cancer

Data in Brief, 2017
Stimulation of insulin production by insulin secretagogue use may impact T helper cells’ cytokine production. This dataset presents the relationship between baseline insulin secretagogues use in women diagnosed with breast cancer and type 2 diabetes ...
Zachary A.P. Wintrob, Jeffrey P. Hammel, George K. Nimako, Dan P. Gaile, Alan Forrest, Alice C. Ceacareanu   +5 more
doaj   +1 more source

Nutritional priorities to support GLP‐1 therapy for obesity: A joint Advisory from the American College of Lifestyle Medicine, the American Society for Nutrition, the Obesity Medicine Association, and The Obesity Society

Obesity, EarlyView.
Abstract Background Glucagon‐like peptide 1 receptor agonists and combination medications (hereafter collectively referred to as GLP‐1s) are shifting the treatment landscape for obesity. However, real‐world challenges and limited clinician and public knowledge on nutritional and lifestyle interventions can limit GLP‐1 efficacy, equitable results, and ...
Dariush Mozaffarian, Monica Agarwal, Monica Aggarwal, Lydia Alexander, Caroline M. Apovian, Shagun Bindlish, Jonathan Bonnet, W. Scott Butsch, Sandra Christensen, Eugenia Gianos, Mahima Gulati, Alka Gupta, Debbie Horn, Ryan M. Kane, Jasdeep Saluja, Deepa Sannidhi, Fatima Cody Stanford, Emily A. Callahan   +17 more
wiley   +1 more source