Results 61 to 70 of about 34,073 (255)
Neuropeptide receptors as potential antiepileptic drug targets : focus on the ghrelin axis [PDF]
, 2014 Epilepsy is a very serious neurological disorder which is often underrepresented. Around 50 million individuals worldwide have active epilepsy with recurrent seizures and in spite of the medical advances over the years, 30% of these patients remain as ...
Portelli, Jeanelle
core +1 more source
Frontiers in Physiology, 2019 BackgroundThe calcium-sensing receptor (CaSR) has been localized and characterized in numerous tissues throughout the body. In the mammalian gastrointestinal tract, the CaSR is known to act as a nutrient sensor and has recently been found to play a role ...
Maria J. Barahona +10 more
doaj +1 more source
Aging Cell, Volume 24, Issue 4, April 2025.Adequate NADK/NADK2 level is essential to the proper functioning of redox and folate cycles and the purine biosynthesis pathway, and as well as maintenance of GSIS response. During aging, diminished NADK/NADK2 expression alters the metabolic status quo, increasing AICAR production. The latter activates AMPK and suppresses GSIS.
Guan‐Jie Li +6 more
wiley +1 more source
Dos peptídeos liberadores do hormônio de crescimento (HC) à ghrelina: descoberta de novos moduladores da secreção de HC [PDF]
, 2006 Growth hormone (GH)-releasing hormone and somatostatin modulate GH secretion. A third mechanism has been discovered in the last decade, involving the action of GH secretagogues.
Lengyel, Ana Maria Judith
core +4 more sources
Arrestin‐centred interactions at the membrane and their conformational determinants
British Journal of Pharmacology, EarlyView.Abstract More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling. Originally named for their capacity to hinder GPCR coupling to G proteins and facilitate receptor desensitisation, arrestins have emerged as key hubs for a myriad of
Owen Underwood +3 more
wiley +1 more source
Secretagogue (Caerulein) induced pancreatitis in rodents
, 2013 Acute pancreatitis is one of the most common diseases in gastroenterology. The incidence of acute pancreatitis per 100,000 population ranges from 10 to 46 per year.
J. Mayerle, M. Sendler, M. Lerch
semanticscholar +1 more source
Protective effects of urocortin 2 against caerulein-induced acute pancreatitis. [PDF]
, 2019 Because little is known about the role of corticotropin-releasing factor (CRF) agonists in regulating responses in pancreatitis, we evaluated the effects of urocortin 2 (UCN2) and stressin1 in caerulein-induced acute pancreatitis (AP) model in rats. Male
Bhargava, Aditi +6 more
core +1 more source
Obestatin stimulates glucose-induced insulin secretion through ghrelin receptor GHS-R
Scientific Reports, 2017 Orexigenic hormone ghrelin and anorexic hormone obestatin are encoded by the same preproghrelin gene. While it is known that ghrelin inhibits glucose-stimulated insulin secretion (GSIS), the effect of obestatin on GSIS is unclear.
Geetali Pradhan +7 more
doaj +1 more source
Factors associated with beta-cell dysfunction in type 2 diabetes: the BETADECLINE study. [PDF]
PLoS ONE, 2014 AIMS: Beta-cell dysfunction is an early event in the natural history of type 2 diabetes. However, its progression is variable and potentially influenced by several clinical factors.
Giuseppina T Russo +5 more
doaj +1 more source
Predictors of Mortality in Patients With Multiple Endocrine Neoplasia Type 1
Clinical Endocrinology, EarlyView.SUMMARY Objective Multiple Endocrine Neoplasia Type 1 (MEN 1) is an autosomal dominant disease predisposing to hyperplasia and neoplasia in diverse endocrine tissues. Patients typically present with endocrine abnormalities before the age of 30 years and have reduced life expectancy.
Jasmine J. Zhu, John R Burgess
wiley +1 more source