Results 71 to 80 of about 15,945 (227)

A role of ghrelin in canine mammary carcinoma cells proliferation, apoptosis and migration

BMC Veterinary Research, 2012
Background Ghrelin is a natural ligand of the growth hormone secretagogue receptor (GHS-R). They are often co-expressed in multiple human tumors and related cancer cell lines what can indicate that the ghrelin/GHS-R axis may have an important role in ...
Majchrzak Kinga, Pawłowski Karol M, Orzechowska Emilia J, Dolka Izabella, Mucha Joanna, Motyl Tomasz, Król Magdalena   +6 more
doaj   +1 more source

Association of Deviation From Glycated Hemoglobin (HbA1c) Target in the Guidelines for the Treatment of Diabetes in Older Patients With Place of Care and Interval Between HbA1c Tests Among Older Patients Receiving Home Medical Care

Geriatrics &Gerontology International, Volume 26, Issue 1, January 2026.
ABSTRACT Aim We examined the association of deviation from the glycated hemoglobin (HbA1c) target proposed in the Guidelines for the Treatment of Diabetes in Older Patients in Japan 2016 with the place of care and interval between HbA1c tests among older patients with diabetes.
Mari Fukuhara, Takuma Kimura, Yoshiyuki Sasaki, Satoshi Fukuhara, Suguru Mabuchi, Kazue Ota, Masanaga Yamawaki, Masayoshi Hashimoto   +7 more
wiley   +1 more source

Ghrelin receptors in non-mammalian vertebrates

Frontiers in Endocrinology, 2013
The growth hormone secretagogue-receptor (GHS-R) was discovered in humans and pigs in 1996. The endogenous ligand, ghrelin, was discovered three years later, in 1999, and our understanding of the physiological significance of the ghrelin system in ...
Hiroyuki eKaiya, Kenji eKangawa, Mikiya eMiyazato   +2 more
doaj   +1 more source

Nutrient-sensing growth hormone secretagogue receptor in macrophage programming and meta-inflammation

Molecular Metabolism
Objective: Obesity-associated chronic inflammation, aka meta-inflammation, is a key pathogenic driver for obesity-associated comorbidity. Growth hormone secretagogue receptor (GHSR) is known to mediate the effects of nutrient-sensing hormone ghrelin in ...
Da Mi Kim, Jong Han Lee, Quan Pan, Hye Won Han, Zheng Shen, Sahar Eshghjoo, Chia-Shan Wu, Wanbao Yang, Ji Yeon Noh, David W. Threadgill, Shaodong Guo, Gus Wright, Robert Alaniz, Yuxiang Sun   +13 more
doaj   +1 more source

Plecanatide: a new guanylate cyclase agonist for the treatment of chronic idiopathic constipation

Therapeutic Advances in Gastroenterology, 2018
Chronic constipation affects millions of Americans, consumes significant healthcare resources, and significantly affects quality of life (QOL). Recently, several new treatment options have become available for the treatment of constipation, including ...
Satish S.C. Rao
doaj   +1 more source

Ghrelin accelerates growth of olfactory ensheathing cells through ERK pathway

Indian Journal of Animal Sciences, 2016
Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor (GHSR), stimulates growth hormone (GH) secretion and has both orexigenic and adipogenic effects.
PEI ZHANG, L I RUIFENG, L V HUICHENG, YANXIANG TONG, ZHIQIANG CHANG, Y U BAOLONG, W U YIMIN   +6 more
doaj   +1 more source

Induction of Secretagogue Independent Gastric Acid Secretion via a Novel Aspirin-Activated Pathway

Frontiers in Physiology, 2019
Aspirin has been widely recommended for acute and chronic conditions for over 2,000 years. Either single or repetitive doses are commonly used for analgesic and antipyretic reasons and to prevent heart attacks, stroke, and blood clot formation.
Alice Miriam Kitay, Alice Miriam Kitay, Florentina Sophie Ferstl, Alexander Link, John Peter Geibel, John Peter Geibel   +5 more
doaj   +1 more source

Circulating adipokines data associated with insulin secretagogue use in breast cancer patients

Data in Brief, 2017
Oral drugs stimulating endogenous insulin production (insulin secretagogues) may have detrimental effects on breast cancer outcomes. The data presented shows the relationship between pre-existing insulin secretagogues use, adipokine profiles at the time ...
Zachary A.P. Wintrob, Jeffrey P. Hammel, George K. Nimako, Zahra S. Fayazi, Dan P. Gaile, Alan Forrest, Alice C. Ceacareanu   +6 more
doaj   +1 more source

Characterization of blood-derived exosomal proteins after exercise

Journal of International Medical Research, 2020
Objective To assess changes in plasma exosome levels and protein content in mice after long-term exercise. Methods We subjected 9-month-old adult C57BL/6J mice to daily treadmill running exercise for 4 weeks prior to the isolation of blood-derived ...
Hongkai Xiang, Shisheng Chen, Junhan Zhou, Junxiu Guo, Qingfeng Zhou, Qishuang Zhou   +5 more
doaj   +1 more source

Quercetin-3-glucoside increases low-density lipoprotein receptor (LDLR) expression, attenuates proprotein convertase subtilisin/kexin 9 (PCSK9) secretion, and stimulates LDL uptake by Huh7 human hepatocytes in culture

FEBS Open Bio, 2014
Low-density lipoprotein receptor (LDLR) mediates hepatic clearance of plasma cholesterol; proprotein convertase subtilisin/kexin 9 (PCSK9) opposes this clearance by promoting LDLR degradation.
Majambu Mbikay, Francine Sirois, Sonia Simoes, Janice Mayne, Michel Chrétien   +4 more
doaj   +1 more source