Results 71 to 80 of about 34,073 (255)

Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor.

Endocrinology, 2004
Ghrelin promotes fat accumulation, despite potent stimulation of the lipolytic hormone, GH. The function of the major circulating isoform of ghrelin, des-octanoyl ghrelin, is unclear, because it does not activate the GH secretagogue receptor (GHS-R1a ...
N. Thompson, Dave A S Gill, R. Davies, N. Loveridge, P. Houston, I. Robinson, T. Wells   +6 more
semanticscholar   +1 more source

A review of the safety of sodium‐glucose co‐transporter‐2 inhibitors

Diabetes, Obesity and Metabolism, EarlyView.
Abstract The development of sodium‐glucose co‐transporter‐2 (SGLT2) inhibitors represents a major turning point in the effort to preserve kidney function and prevent cardiovascular events and heart failure hospitalisations in those at high risk. These agents have now transcended their original glucose‐lowering indication and provide a range of clinical
Daniel Vincent O'Hara, Meg J. Jardine
wiley   +1 more source

Novel mechanisms of growth hormone regulation: growth hormone-releasing peptides and ghrelin [PDF]

, 2006
Growth hormone secretion is classically modulated by two hypothalamic hormones, growth hormone-releasing hormone and somatostatin. A third pathway was proposed in the last decade, which involves the growth hormone secretagogues.
Lengyel, Ana Maria Judith
core   +2 more sources

Plasma LEAP2 concentration is associated with energy intake and postprandial insulin increase depending on meal size but not weight status in men

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims While LEAP2 is increasingly recognized as an appetite‐regulating hormone, its role in meal regulation and the dynamics of postprandial LEAP2 concentrations remain poorly understood in humans. The aim of the study was to (1) assess postprandial LEAP2 concentrations following a recommended‐energy breakfast, exploring potential association ...
María F. Andreoli, Pablo N. De Francesco, Olga E. Titova, Mario Perello, Helgi B. Schiöth   +4 more
wiley   +1 more source

Obesity and the gut microbiota: implications of neuroendocrine and immune signaling

The FEBS Journal, Volume 292, Issue 6, Page 1397-1420, March 2025.
An unhealthy diet impairs the symbiotic relationship between the gut microbiota and the host, contributing to obesity. At the intestinal level, identification of host–microbe events essential for proper neuroendocrine/immune signaling is key to the development of microbiome‐based strategies to promote metabolic health in obesity (probiotics ...
Marina Romaní‐Pérez, Rebeca Líebana‐García, Alejandra Flor‐Duro, Daniel Bonillo‐Jiménez, Clara Bullich‐Vilarrubias, Marta Olivares, Yolanda Sanz   +6 more
wiley   +1 more source

Calcium-sensing receptor inhibits secretagogue-induced electrolyte secretion by intestine via the enteric nervous system.

American Journal of Physiology - Gastrointestinal and Liver Physiology, 2012
Bacterial toxins such as cholera toxin induce diarrhea by both direct epithelial cell generation of cyclic nucleotides as well as stimulation of the enteric nervous system (ENS).
Sam X. Cheng
semanticscholar   +1 more source

Identification and characterisation of enteroaggregative Escherichia coli subtypes associated with human disease [PDF]

, 2020
Enteroaggregative E. coli (EAEC) are a major cause of diarrhoea worldwide. Due to their heterogeneity and carriage in healthy individuals, identification of diagnostic virulence markers for pathogenic strains has been difficult.
Brett, Bernard, Bundy, Leah, Chattaway, Marie A., Crossman, Lisa C., Ellis, Samuel J., Hölken, Johanna M., Kay, Gemma L., McGrath, Conor J., Schüller, Stephanie, Wain, John   +9 more
core   +1 more source

The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion

eLife
Life histories of oviparous species dictate high metabolic investment in the process of gonadal development leading to ovulation. In vertebrates, these two distinct processes are controlled by the gonadotropins follicle-stimulating hormone (FSH) and ...
Lian Hollander-Cohen, Omer Cohen, Miriam Shulman, Tomer Aiznkot, Pierre Fontanaud, Omer Revah, Patrice Mollard, Matan Golan, Berta Levavi-Sivan   +8 more
doaj   +1 more source

Gastrointestinal symptoms in patients receiving imeglimin in combination with metformin: A post‐hoc analysis of imeglimin clinical trial data

Journal of Diabetes Investigation, Volume 16, Issue 4, Page 629-638, April 2025.
Gastrointestinal symptoms, including diarrhea, are common in patients with type 2 diabetes receiving imeglimin plus metformin combination therapy. Most of these symptoms resolved within 1 week and were associated with greater improvement in HbA1c levels.
Jumpei Ito, Katsuhiko Hagi, Kenji Kochi, Kohjiro Ueki, Hirotaka Watada, Kohei Kaku   +5 more
wiley   +1 more source

Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor.

Endocrinology, 2006
Ghrelin, an acylated peptide produced predominantly in the stomach, stimulates feeding and GH secretion via interactions with the GH secretagogue type 1a receptor (GHS-R1a), the functionally active form of the GHS-R.
K. Toshinai, H. Yamaguchi, Yuxiang Sun, Roy G. Smith, A. Yamanaka, T. Sakurai, Y. Date, M. S. Mondal, T. Shimbara, Takashi Kawagoe, N. Murakami, M. Miyazato, K. Kangawa, M. Nakazato   +13 more
semanticscholar   +1 more source