Results 91 to 100 of about 2,579,679 (405)

Paraneoplastic hypoglycaemia secondary to IGF-2 secretion from a metastatic gastrointestinal stromal tumour [PDF]

, 2020
We report the case of a 79-year-old male with previous history of non-Hodgkin's lymphoma in remission, who presented acutely to the Accident and Emergency department with recurrent episodes of hypoglycaemia.
Dimitriadis, Georgios K., Drakou, Eftychia E., Ganguly, Ratnadeep, Giovos, Georgios, Grossman, Ashley B., Kosmas, Christos, Leca, Bianca, Murthy, Narasimha, Onyema, Michael C., Randeva, Harpal S.   +9 more
core   +1 more source

Redox‐dependent binding and conformational equilibria govern the fluorescence decay of NAD(P)H in living cells

FEBS Letters, EarlyView.
In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker, Nimit Mistry, Nicoletta Plotegher, Elizabeth R. Westbrook, Michael D. E. Sewell, John Carroll, Gyorgy Szabadkai, Angus J. Bain, Michael R. Duchen   +8 more
wiley   +1 more source

Secrets of a Secretin [PDF]

Structure, 2013
Secretins are major constituents of bacterial type III secretion systems (T3SS). In this issue of Structure, Kowal and colleagues report on the cryo-EM structure of the native YscC secretin from Yersinia, revealing its internal symmetry and mode of length adaptation.
openaire   +3 more sources

Doxorubicin Selectively Inhibits Brain versus Atrial Natriuretic Peptide Gene Expression in Cultured Neonatal Rat Myocytes [PDF]

, 1999
Doxorubicin is an antineoplastic agent with significant cardiotoxicity. We examined the effects of this agent on the expression of the natriuretic peptide (NP) genes in cultured neonatal rat atrial myocytes.
Chen, Songcang, Garami, Miklós, Gardner, D. G.   +2 more
core   +1 more source

Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice

FEBS Letters, EarlyView.
In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász, Albert Bálint Papp, Lukács Sándor Lesinszki, Attila Mócsai, Tamás Varga, László Nagy, Péter Gogolák   +6 more
wiley   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Concurrent Secrets

Discrete Event Dynamic Systems, 2006
Given a finite state system with partial observers and for each observer, a regular set of trajectories which we call a secret, we consider the question whether the observers can ever find out that the trajectory of the system belongs to some secret. We search for a regular control on the system, enforcing the specified secrets on the observers, even ...
Badouel, Eric, Bednarczyk, Marek, Borzyszkowski, Andrzej, Caillaud, Benoit, Darondeau, Philippe   +4 more
openaire   +3 more sources

Secret of Life, Secret of Death [PDF]

Romanian Journal of Psychoanalysis, 2020
Abstract From his first Freudian studies, but especially in S. Freud’s correspondence with W. Fliess, the term “secret” (geheim, geheimnis) appears frequently, hence its weight and significance in psychic life, and implicitly as a form of intimacy and of confidentiality shared in the analytical relationship.
openaire   +2 more sources

Tumor microenvironment induces innate RAF-inhibitor resistance through HGF secretion

Nature, 2012
Drug resistance presents a challenge to the treatment of cancer patients. Many studies have focused on cell-autonomous mechanisms of drug resistance. By contrast, we proposed that the tumour micro-environment confers innate resistance to therapy. Here we
R. Straussman, Teppei Morikawa, K. Shee, Michal Barzily-Rokni, Z. Qian, Jinyan Du, Ashli Davis, Margaret M. Mongare, Joshua Gould, Dennie T. Frederick, Z. Cooper, P. Chapman, D. Solit, A. Ribas, R. Lo, K. Flaherty, S. Ogino, J. Wargo, T. Golub   +18 more
semanticscholar   +1 more source

Effect of the glucocorticoid receptor antagonist Org 34850 on fast and delayed feedback of corticosterone release [PDF]

, 2007
We investigated the effect of the glucocorticoid receptor (GR) antagonist Org 34850 on fast and delayed inhibition of corticosterone secretion in response to the synthetic glucocorticoid methylprednisolone (MPL).
Craighead, Mark, Grassie, Morag, Harrison, Louse R., Lightman, Stafford L., MacSweeney, Cliona P., Spiga, Francesca, Thomson, Fiona .J., Wood, Susan A.   +7 more
core   +1 more source