Results 91 to 100 of about 2,034,530 (343)
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Tau Secretion: Good and Bad for Neurons
Frontiers in Neuroscience, 2019 In Alzheimer’s disease (AD), neurofibrillary tangles (NFTs), lesions composed of hyperphosphorylated and aggregated tau, spread from the transentorhinal cortex to the hippocampal formation and neocortex.
Camille Pernègre +5 more
doaj +1 more source
Transcriptome analysis of discus fish (Symphysodon haraldi) skin and brain to identify genes involved in ‘milk’ secretion during parental care [PDF]
, 2020 Yu-Ling Wei +3 more
openalex +1 more source
Improvement of Lipotoxicity-Induced Islet β Cellular Insulin Secretion Disorder by Osteocalcin [PDF]
, 2022 Yafang Zhang +4 more
openalex +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Frontiers in Cellular Neuroscience, 2018 Neuroendocrine chromaffin cells represent an excellent model to study the molecular mechanisms associated with the exo-endocytotic cycle of neurotransmitter release.
Yolanda Gimenez-Molina +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Nasal mucosa secretion exudation response to cold air in bronchial asthma patients
Бюллетень сибирской медицины, 2017 Background. Combined airway hyper responsiveness to cold and hypoosmotic stimuli in asthma patients results in impairment of lung respiration function and poor disease control compared to patients with isolated airway hyper responsiveness to only one of ...
Eduard V. Nekrasov +2 more
doaj +1 more source
Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system [PDF]
, 2012 K. Wallden +7 more
openalex +1 more source