Results 81 to 90 of about 1,596,415 (263)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Effect of Intraduodenal Bile and Na-Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Secretin, Pancreatic Polypeptide, and Gastrin in Man [PDF]

, 1990
The effect of intraduodenally administered cattle bile (CB) and Na-taurodeoxycholate (TDC) on basal pancreatic secretion and plasma levels of secretin, pancreatic polypeptide (PP), and gastrin were investigated on two separate days in 10 fasting ...
Fiedler, F., Teufel, Johannes, Riepl, Rudolf L., Burhol, P. G., Scharl, A., Lehnert, Peter, Hempen, I.   +6 more
core   +1 more source

Presence and Effects of Pituitary Adenylate Cyclase Activating Polypeptide Under Physiological and Pathological Conditions in the Stomach

Frontiers in Endocrinology, 2018
Pituitary adenylate cyclase activating polypeptide (PACAP) is a multifunctional neuropeptide with widespread occurrence throughout the body including the gastrointestinal system.
Dora Reglodi, Anita Illes, Anita Illes, Balazs Opper, Eszter Schafer, Andrea Tamas, Gabriella Horvath   +6 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Established microbial colonies can survive type VI secretion assault [PDF]

, 2015
Type VI secretion (T6S) is a cell-to-cell injection system that can be used as a microbial weapon. T6S kills vulnerable cells, and is present in close to 25% of sequenced Gram-negative bacteria.
Ned S Wingreen, Marek Basler (173162), Basler, Marek, Ringel, Peter, David Bruce Borenstein, Peter Ringel (816293), Borenstein, David Bruce, Peter Ringel, Wingreen, Ned S., Wingreen, Ned, Marek Basler, David Bruce Borenstein (413437), Ned S. Wingreen (10926)   +12 more
core   +2 more sources

The secretion and retraction processes of pollination drops of ancient Platycladus orientalis and their response to different pollen types

Frontiers in Plant Science
IntroductionThe pollination drop (PD) is an important ovular secretion that occurs during the pollination stage in gymnosperms.MethodsIn this study, ancient Platycladus orientalis trees near the Mausoleum of the Yellow Emperor were selected to ...
Wei Zhou, Liyan Gong, Xiaobing Wang, Nawen Li, Xin Zhang, Jianjun Liu   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The level of mendione redox-cycling in pancreatic β-cells is proportional to the glucose concentration: role of NADH and consequences for insulin secretion

, 2012
Pancreatic β-cells release insulin in response to elevation of glucose from basal (4–7 mM) to stimulatory (8–16 mM) levels. Metabolism of glucose by the β-cell results in the production of low levels of reactive oxygen intermediates (ROI), such as ...
Womack, Trayce, Gray, Joshua P., Joshua P. Gray, Peter J.S. Smith, Smith, Peter J. S., Meridith Palo, Heart, Emma, Trayce Womack, Emma Heart   +8 more
core   +1 more source

Role of Phospholipases in Fungal Fitness, Pathogenicity and Drug Development- Lessons from Cryptococcus neoformans

Frontiers in Microbiology, 2010
Many pathogenic microbes, including many fungi, produce phospholipases which facilitate survival of the pathogen in vivo, invasion and dissemination throughout the host, expression of virulence traits and evasion of host immune defense mechanisms.
Julianne eDjordjevic
doaj   +1 more source