Results 91 to 100 of about 1,596,415 (263)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Effect of Intraduodenal Bile and Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Vasoactive Intestinal Polypeptide and Somatostatin in Man [PDF]

, 1994
Intraduodenal (i.d.) application of bile or Na-taurodeoxycholate (TDC) dose dependently enhances basal exocrine pancreatic secretion. The hydrokinetic effect is mediated at least in part by secretin.
Teufel, Johannes, Riepl, Rudolf L., Fiedler, Fritz, Lehnert, Peter   +3 more
core   +1 more source

Calcitonin gene-related peptide is a stimulator of renin secretion [PDF]

, 1988
Calcitonin gene-related peptide (CGRP) was found to stimulate renin secretion in vivo in normal human volunteers. Moreover, CGRP stimulated the release of renin in vitro from isolated rat renal juxtaglomerular cells (half-maximal effective concentration [
Fischer, J. A., R Muff, Gnädinger, M. P., Uehlinger, D. E., Weidmann, P., A Kurtz, M P Gnädinger, W Born, Muff, R., J M Lundberg, T Hökfelt, P Weidmann, Kurtz, Armin, Lundberg, J. M., D E Uehlinger, Born, W., Millberg, B. I., Hökfelt, T., J A Fischer, B I Millberg   +19 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Global transcriptional profiling of Burkholderia pseudomallei under salt stress reveals differential effects on the Bsa type III secretion system. [PDF]

, 2010
BACKGROUND: Burkholderia pseudomallei is the causative agent of melioidosis where the highest reported incidence world wide is in the Northeast of Thailand, where saline soil and water are prevalent.
Stabler, Richard A., Sunee Korbsrisate, Stevens, Mark P, Pornpan Pumirat, Ekapot Singsuksawat, Wren, Brendan W, Korbsrisate, Sunee, Singsuksawat, Ekapot, Mark P Stevens, Muangsombut, Veerachat, Veerachat Muangsombut, Cuccui, Jon, Richard A Stabler, Joanne M Stevens, Pumirat, Pornpan, Wren, Brendan W., Stabler, Richard A, Stevens, Joanne M, Stevens, Joanne M.; id_orcid, Stevens, Mark P., Jon Cuccui, Brendan W Wren, Singsuksawat Ekapot, Stevens Mark P, Cuccui Jon, Stabler Richard A, Stevens Joanne M, Korbsrisate Sunee, Wren Brendan W, Muangsombut Veerachat, Pumirat Pornpan   +30 more
core   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion

, 2009
Pyruvate cycling has been implicated in glucose-stimulated insulin secretion (GSIS) from pancreatic beta-cells. The operation of some pyruvate cycling pathways is proposed to necessitate malate export from the mitochondria and NADP(+)-dependent ...
Gray, Joshua P., Pongratz, Rebecca L., Collis, Leon P., Heart, Emma, Smith, Peter J.S., Cline, Gary W.   +5 more
core   +1 more source

Loss of AMP-activated protein kinase alpha 2 subunit in mouse beta-cells impairs glucose-stimulated insulin secretion and inhibits their sensitivity to hypoglycaemia [PDF]

, 2010
AMPK (AMP-activated protein kinase) signalling plays a key role in whole-body energy homoeostasis, although its precise role in pancreatic beta-cell function remains unclear.
Withers, DJ, Ashford, ML, Smith, Mark A., Al-Qassab, H, Piipari, K, Piipari, Kaisa, Al-Qassab, Hind, Smith, Mark A, Viollet, Benoit, Ashford, Michael Lj, Viollet, B, Beall, Craig, Smith, MA, Withers, Dominic J, Parker, N, Carling, David, Parker, Nadeene, Withers, Dominic J., Ashford, Michael L. J.; id_orcid, Beall, C, Carling, D   +20 more
core   +1 more source

Ultrastructure and oil secretion in Hiptage sericea Hook

Acta Societatis Botanicorum Poloniae, 2014
The oil secreting glands of Hiptage sericea Hook. consist of three regions: epithelial, sub-epithelial and sub-glandular. In early stages, the oil secreting cells are characterized by the presence of plastids with starch grains and electron translucent ...
K. Arumugasamy, K. Udaiyan, S. Manian, V. Sugavanam   +3 more
doaj   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source