Results 61 to 70 of about 2,059,241 (311)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The chlamydial type III secretion mechanism: Revealing cracks in a tough nut

Frontiers in Cellular and Infection Microbiology, 2010
Present-day members of the Chlamydiaceae contain parasitic bacteria that have been co-evolving with their eukaryotic hosts over hundreds of millions of years.
Helen Jennifer Betts-Hampikian, Kenneth eFields   +1 more
doaj   +1 more source

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome [PDF]

, 2009
Inflammasomes activate caspase-1 for processing and secretion of the cytokines interleukin-1 beta (IL-1 beta) and IL-18. Cryopyrin/NALP3/NLRP3 is an essential component of inflammasomes triggered by microbial ligands, danger-associated molecular patterns
Mohamed Lamkanfi, James L. Mueller, Alberto C. Vitari, Shahram Misaghi, Anna Fedorova, Kurt Deshayes, Wyne P. Lee, Hal M. Hoffman, Vishva M. Dixit, Aguilar-Bryan, Ashcroft, Boyden, Cassel, Clement, Dostert, Duncan, Halle, Hamon, Hoffman, Hornung, Kanneganti, Kanneganti, Laliberte, Lamkanfi, Lamkanfi, Locovei, Ma, Mariathasan, Mariathasan, Martinon, Marty, Meyer, Miki, Miki, Pelegrin, Pelegrin, Perregaux, Riddle, Rosengren, Schott, Solle, Stoller, Sutterwala, Yvan-Charvet   +43 more
core   +2 more sources

Secrets du secret

Acta Fabula, 2003
Cet article est un compte-rendu du livre : Sigila, n° 11, « Tonalités secrètes », Gris-France, printemps-été 2003.
openaire   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Diagnostic and referral pathways in patients with rare lipodystrophy and insulin-resistance syndromes: key milestones assessed from a national reference center

Orphanet Journal of Rare Diseases
Background Rare syndromes of lipodystrophy and insulin-resistance display heterogeneous clinical expressions. Their early recognition, diagnosis and management are required to avoid long-term complications.
Bruno Donadille, Sonja Janmaat, Héléna Mosbah, Inès Belalem, Sophie Lamothe, Mariana Nedelcu, Anne-Sophie Jannot, Sophie Christin-Maitre, Bruno Fève, Camille Vatier, Corinne Vigouroux   +10 more
doaj   +1 more source

A novel platform for the production of nonhydroxylated gelatins based on the methylotrophic yeast Hansenula polymorpha [PDF]

, 2007
The use of yeast as a host for heterologous expression of proteins that are normally derived from animal tissue is a promising way to ensure defined products that are devoid of potential harmful animal side products.
Boer, Arjo L. de,, Geerlings, Torsten H.,, Klei, Ida J. van der,, Lunenborg, Marcel G.J.,, Veenhuis, Marten,   +4 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The pathophysiology of intestinal lipoprotein production

Frontiers in Physiology, 2015
Intestinal lipoprotein production is a multistep process, essential for the absorption of dietary fats and fat-soluble vitamins. Chylomicron assembly begins in the endoplasmic reticulum with the formation of primordial, phospholipids-rich particles that ...
Antonina eGiammanco, Angelo Baldassare Cefalu', Davide eNoto, Maurizio eAverna   +3 more
doaj   +1 more source

Membrane Topology of the Lactococcal Bacteriocin ATP-binding Cassette Transporter Protein LcnC. Involvement of LcnC in Lactococcin A Maturation [PDF]

, 1999
Many non-lantibiotic bacteriocins of lactic acid bacteria are produced as precursors with N-terminal leader peptides different from those present in preproteins exported by the general sec-dependent (type II) secretion pathway. These bacteriocins utilize
Axelsson, Bardwell, Birnboim, Boyd, Calamia, Casadaban, Chopin, Christian M. Franke, Danielsen, Dassa, Diep, Dinh, Dower, Ehrmann, Eisenberg, Fath, Franke, Gasson, Gerard Venema, Gilmore, Higgins, Holo, Hwang, Håvarstein, Jan Kok, Jan Tiemersma, Kast, Klein, Kok, Kuipers, Kyhse-Anderson, Kyte, Laemmli, Loo, Manoil, Millan, Miller, Newton, Pearce, Prinz, Quadri, Rao, Rince, Rottlander, Sambrook, Schägger, Simon, Sipos, Stoddard, Tagg, Terzaghi, Van Belkum, Van de Guchte, Venema, Venema, Venema, Vieira, Von Heijne, Wu, Yanisch-Perron, Zhang   +60 more
core   +1 more source