Results 31 to 40 of about 1,882,580 (346)

The secreted secret of PCSK9 [PDF]

Science-Business eXchange, 2009
Amgen researchers have demonstrated that blocking secreted PCSK9 in mice and nonhuman primates lowers LDL cholesterol. The findings bolster the case for an antibody-based approach to blocking the protein, which is a genetically validated target for hypercholesterolemia.
openaire   +2 more sources

Nasal mucosa secretion exudation response to cold air in bronchial asthma patients

Бюллетень сибирской медицины, 2017
Background. Combined airway hyper responsiveness to cold and hypoosmotic stimuli in asthma patients results in impairment of lung respiration function and poor disease control compared to patients with isolated airway hyper responsiveness to only one of ...
Eduard V. Nekrasov, Anna G. Prikhodkо, Juliy M. Perelman   +2 more
doaj   +1 more source

Osteoblast function in patients with idiopathic osteonecrosis of the femoral head: implications for a possible novel therapy

Bone & Joint Research, 2021
Aims: To investigate whether idiopathic osteonecrosis of the femoral head (ONFH) is related to impaired osteoblast activities. Methods: We cultured osteoblasts isolated from trabecular bone explants taken from the femoral head and the intertrochanteric ...
Leila Maestro-Paramio, Eduardo García-Rey, Fátima Bensiamar, Laura Saldaña   +3 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Genomic Analysis of ATP Efflux in Saccharomyces cerevisiae

G3: Genes, Genomes, Genetics, 2016
Adenosine triphosphate (ATP) plays an important role as a primary molecule for the transfer of chemical energy to drive biological processes. ATP also functions as an extracellular signaling molecule in a diverse array of eukaryotic taxa in a conserved ...
Theodore W. Peters, Aaron W. Miller, Cendrine Tourette, Hannah Agren, Alan Hubbard, Robert E. Hughes   +5 more
doaj   +1 more source

Regulation of Protein Secretion by … Protein Secretion? [PDF]

Cell Host & Microbe, 2008
Mycobacterium tuberculosis (Mtb) requires an alternative protein secretion system, ESX1, for virulence. Recently, Raghavan et al. (2008) reported a new regulatory circuit that may explain how ESX1 activity is controlled during infection. Mtb appears to regulate ESX1 by modulating transcription of associated genes rather than structural components of ...
Sarah M. Fortune, Krishnamohan Atmakuri
openaire   +3 more sources

Salivary secretion in health and disease

Journal of Oral Rehabilitation, 2018
Saliva is a complex fluid produced by 3 pairs of major salivary glands and by hundreds of minor salivary glands. It comprises a large variety of constituents and physicochemical properties, which are important for the maintenance of oral health.
A. Pedersen, C. E. Sørensen, G. Proctor, G. Carpenter, J. Ekström   +4 more
semanticscholar   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Morphology of the Female Receptaculum Seminis of Euschistus heros (FABRICIUS, 1798) (INSECTA: HEMIPTERA: PENTATOMIDAE) [PDF]

Anais da Academia Brasileira de Ciências
Euschistus heros (Fabricius, 1798) (Heteroptera: Pentatomidae) is a soybean pest in Brazil. It has a reproductive success that may be associated with the female receptaculum seminis or spermatheca, a reproductive organ for spermatozoa storage until the ...
EDMILSON A. SOUZA, RAFAELA M.M. DO VAL, LUCIANE C.O. LISBOA, FLÁVIO L. FERNANDES, JOSÉ E. SERRÃO   +4 more
doaj   +1 more source