Results 31 to 40 of about 1,140,351 (290)

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Different members of the IL-1 family come out in different ways: DAMPs vs cytokines?

Frontiers in Immunology, 2013
Intercellular communications control fundamental biological processes required for the survival of multicellular organisms. Secretory proteins are among the most important messengers in this network of information.
Sonia eCarta, Rosa eLavieri, Anna eRubartelli   +2 more
doaj   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Chronic leucine supplementation does not prevent the obesity and metabolic abnormalities induced by monosodium glutamate

Clinical Nutrition Experimental, 2020
Summary: Leucine (Leu) is an essential branched amino acid that regulates several aspects of metabolism and may have the ability to mitigate obesity and type 2 diabetes.
Vanessa Marieli Ceglarek, Mariana Lima Coelho, Ricardo Lima Coelho, Douglas Lopes Almeida, Willian do Nascimento de Souza Rodrigues, Rafael Ludmann Camargo, Luiz Felipe Barella, Paulo Cezar de Freitas Mathias, Sabrina Grassiolli   +8 more
doaj  

Message Randomization and Strong Security in Quantum Stabilizer-Based Secret Sharing for Classical Secrets [PDF]

Designs, Codes and Cryptography, vol.88, no.9, pp.1893-1907, Sept. 2020, 2019
We improve the flexibility in designing access structures of quantum stabilizer-based secret sharing schemes for classical secrets, by introducing message randomization in their encoding procedures. We generalize the Gilbert-Varshamov bound for deterministic encoding to randomized encoding of classical secrets.
arxiv   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

FEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga, Kazuki Harada, Takuya Yamauchi, Tetsuya Kitaguchi, Masami Yokota Hirai, Mitsuharu Matsumoto, Takashi Tsuboi   +6 more
wiley   +1 more source

The chlamydial type III secretion mechanism: Revealing cracks in a tough nut

Frontiers in Cellular and Infection Microbiology, 2010
Present-day members of the Chlamydiaceae contain parasitic bacteria that have been co-evolving with their eukaryotic hosts over hundreds of millions of years.
Helen Jennifer Betts-Hampikian, Kenneth eFields   +1 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

A Novel Protocol for the Isolation of Fungal Extracellular Vesicles Reveals the Participation of a Putative Scramblase in Polysaccharide Export and Capsule Construction in Cryptococcus gattii

mSphere, 2019
Regular protocols for the isolation of fungal extracellular vesicles (EVs) are time-consuming, hard to reproduce, and produce low yields. In an attempt to improve the protocols used for EV isolation, we explored a model of vesicle production after growth
Flavia C. G. Reis, Beatriz S. Borges, Luísa J. Jozefowicz, Bianca A. G. Sena, Ane W. A. Garcia, Lia C. Medeiros, Sharon T. Martins, Leandro Honorato, Augusto Schrank, Marilene H. Vainstein, Livia Kmetzsch, Leonardo Nimrichter, Lysangela R. Alves, Charley C. Staats, Marcio L. Rodrigues   +14 more
doaj   +1 more source