Results 141 to 150 of about 61,645 (272)

Method standardization of secretome production, collection, and characterization: New insights and challenges

Regenerative Therapy
Stem cell transplantation remains at the centre of regenerative therapy. Recent, studies have demonstrated that the therapeutic effect of stem cells originates from paracrine reactions from cellular products (secretome) rather than direct cell ...
Nivisti Singh, Yahya E. Choonara, Pradeep Kumar   +2 more
doaj   +1 more source

The role of cardiac acoustic biomarkers in monitoring patients with heart failure: A systematic literature review

ESC Heart Failure, Volume 12, Issue 2, Page 980-997, April 2025.
Abstract Heart failure (HF) creates a considerable clinical, humanistic and economic burden on patients and caregivers as well as on healthcare systems. To attenuate the significant burden of HF, there is a need for enhanced management of patients with HF.
Javed Butler, Malcolm Brown, Philippe Prokocimer, Ashley C. Humphries, Sophie Pope, Olivia Wright, Jun Su, Osama Elnawasany, Bogdan Muresan   +8 more
wiley   +1 more source

Golgi Apparatus‐Associated Secretome Deciphering in Living Cells Enabled by Aggregation‐Induced Emission Luminogen‐Mediated Photocatalytic Proximity Labeling

Aggregate
Golgi apparatus (GA)‐associated secretome runs through the endomembrane system and is critical for inter‐ and intracellular communication networks. However, achieving in situ dissection of the GA‐associated secretome remains challenging owing to the ...
He Wang, Yanli Guo, Zhen Liang, Wenwen Liu, Zijian Guo, Yukui Zhang, Yuncong Chen, Bo Jiang, Lihua Zhang   +8 more
doaj   +1 more source

Projecting the benefit of vericiguat in PARADIGM‐HF and DAPA‐HF populations: Insights from the VICTORIA trial

ESC Heart Failure, Volume 12, Issue 2, Page 1479-1484, April 2025.
Abstract Aims The VICTORIA trial demonstrated a significant reduction in the primary composite outcome of heart failure (HF) hospitalization or cardiovascular death with vericiguat relative to placebo in high‐risk HF. This study aimed to contextualize treatment effects of vericiguat in populations with varying risk profiles simulated from the PARADIGM ...
Veraprapas Kittipibul, Robert J. Mentz, Rebecca Young, Javed Butler, Justin A. Ezekowitz, Carolyn S.P. Lam, Piotr Ponikowski, Adriaan Voors, Stefano Corda, Ciaran McMullan, Christopher M. O'Connor, Kevin J. Anstrom, Paul W. Armstrong, for the VICTORIA Study Group   +13 more
wiley   +1 more source

Spatial and Proteolytic Determinants of Therapeutic Potential in HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Deqian Xie, Wei Dai, Guangzhen Wu
wiley   +1 more source

CCL26‐Mediated Modulation of Endothelial Secretome by Hypoxia‐Induced Tumor‐Derived Exosomes Enhances Metastatic Progression in Head and Neck Cancer

Head &Neck, EarlyView.
ABSTRACT Background Tumor cells adapt to hypoxia by releasing hiTDExs enriched with bioactive molecules that modulate endothelial behavior and promote tumor progression. This study aimed to characterize how hypoxia‐induced HNSCC exosomes reshape the endothelial secretome and contribute to metastatic potential.
Ozel Capik, Sevil Tekman, Betul Gundogdu, Ahsen Kilic, Rumeysa Polat, Omer Aydin, Omer Faruk Karatas   +6 more
wiley   +1 more source

Gelatin sponge scaffolds loaded with adipose-derived mesenchymal stem cell secretome enhance full-thickness skin wound healing in rats

Social Determinants of Health
Background: Skin wounds that are full-thickness present a major clinical problem. Although cell-based treatments have limitations, the secretome of adipose-derived mesenchymal stem cells (ADMSCs) stimulates recovery through paracrine signaling.
Amir Alesheikh , Tayyeb Ghadimi, Abbas Kazemi Ashtiani , Abolfazl Abbaszadeh   +3 more
doaj   +1 more source

Metabolomic and lipidomic signatures of Helicobacter pylori infection: Unveiling biochemical pathways associated with neurodegeneration

iMetaOmics, EarlyView.
Our study employed an integrated lipidomics and metabolomics approach to elucidate Helicobacter pylori‐driven metabolic perturbations along the gut–brain axis. H. pylori infection was established in gastric epithelial (AGS) cells, and the resulting conditioned media (secretome) was collected and exposed to neuronal (IMR‐32) cells.
Meenakshi Kandpal, Tarun Prakash Verma, Siddharth Singh, Hamendra Parmar, Hem Chandra Jha   +4 more
wiley   +1 more source

Spatial multi‐omics identifies a NOTCH3‐mediated capillary–mCAF crosstalk driving immune exclusion in hepatocellular carcinoma

iMeta, EarlyView.
Spatial multi‐omics defines a DLL4–NOTCH3–driven capillary–mCAF axis orchestrating fibrotic remodeling and immune exclusion in hepatocellular carcinoma tumor cores, conferring immune checkpoint blockade resistance. Targeting stromal NOTCH3 disrupts this pro‐fibrotic niche, enhances T cell infiltration, and synergizes with anti‐PD‐1 therapy ...
Fansen Ji, Haochen Li, Qi Wang, Xiaojuan Wang, Jiawei Zhang, Ying Xiao, Huan Li, Hao Liu, Tanqing Long, Boyang Wu, Hao Chen, Haoming Xia, Xinquan Liu, Chuanrui Xu, Yibo Gao, Bingjun Tang, Juan Liu, Shizhong Yang, Jiahong Dong   +18 more
wiley   +1 more source

Topical application of a hyaluronic acid-based hydrogel integrated with secretome of human mesenchymal stromal cells for diabetic ulcer repair

Regenerative Therapy
This preclinical proof-of-concept study aimed to evaluate the effectiveness of secretome therapy in diabetic mice with pressure ulcers. We utilized a custom-made hyaluronic acid (HA)-based porous sponge, which was rehydrated either with normal culture ...
Fabio Salvatore Palumbo, Matteo Calligaris, Laura Calzà, Calogero Fiorica, Vito Antonio Baldassarro, Anna Paola Carreca, Luca Lorenzini, Alessandro Giuliani, Claudia Carcione, Nicola Cuscino, Giovanna Pitarresi, Simone Dario Scilabra, Pier Giulio Conaldi, Cinzia Maria Chinnici   +13 more
doaj   +1 more source