Results 121 to 130 of about 62,112 (253)

CCL26‐Mediated Modulation of Endothelial Secretome by Hypoxia‐Induced Tumor‐Derived Exosomes Enhances Metastatic Progression in Head and Neck Cancer

Head &Neck, EarlyView.
ABSTRACT Background Tumor cells adapt to hypoxia by releasing hiTDExs enriched with bioactive molecules that modulate endothelial behavior and promote tumor progression. This study aimed to characterize how hypoxia‐induced HNSCC exosomes reshape the endothelial secretome and contribute to metastatic potential.
Ozel Capik, Sevil Tekman, Betul Gundogdu, Ahsen Kilic, Rumeysa Polat, Omer Aydin, Omer Faruk Karatas   +6 more
wiley   +1 more source

Method standardization of secretome production, collection, and characterization: New insights and challenges

Regenerative Therapy
Stem cell transplantation remains at the centre of regenerative therapy. Recent, studies have demonstrated that the therapeutic effect of stem cells originates from paracrine reactions from cellular products (secretome) rather than direct cell ...
Nivisti Singh, Yahya E. Choonara, Pradeep Kumar   +2 more
doaj   +1 more source

Metabolomic and lipidomic signatures of Helicobacter pylori infection: Unveiling biochemical pathways associated with neurodegeneration

iMetaOmics, EarlyView.
Our study employed an integrated lipidomics and metabolomics approach to elucidate Helicobacter pylori‐driven metabolic perturbations along the gut–brain axis. H. pylori infection was established in gastric epithelial (AGS) cells, and the resulting conditioned media (secretome) was collected and exposed to neuronal (IMR‐32) cells.
Meenakshi Kandpal, Tarun Prakash Verma, Siddharth Singh, Hamendra Parmar, Hem Chandra Jha   +4 more
wiley   +1 more source

Immune Checkpoint Inhibitors Induce Intestinal Epithelial Injury and a Senescence‐Like Phenotype

iNew Medicine, EarlyView.
ICI treatment promotes the infiltration of activated immune cells into the intestinal mucosa. This inflammatory microenvironment is associated with significant epithelial injury, characterized by the disruption of the epithelial barrier, the depletion of specialized secretory cell lineages, and the induction of a premature senescence phenotype ...
Juan Wang, Shuang Wu, Shuangbiao Wei, Weizhen Xiang, Jianshang Huang, Lei Xiong, Hua Wang, Li Zuo   +7 more
wiley   +1 more source

Growth Factor-Primed WJ-MSC Secretome Enhances Fibroblast Expansion In Vitro

Biomedicines
Background: In regenerative medicine, there is interest in using acellular therapy based on the secretome of mesenchymal stem cells (MSC) to promote wound healing. Wharton’s jelly cells (WJ-MSCs) are a readily available source.
Katia Jarquín-Yáñez, Diana Michel Aguilar-Sandoval, Gabriela Piñón-Zárate, Miguel Angel Herrera-Enríquez, Ivan Daniel Avila-Campos, Beatriz Hernandez-Tellez, Dayana Mayte Dominguez-Diaz, Blanca Esther Blancas-Luciano, Andrés Eliú Castell-Rodríguez   +8 more
doaj   +1 more source

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

Golgi Apparatus‐Associated Secretome Deciphering in Living Cells Enabled by Aggregation‐Induced Emission Luminogen‐Mediated Photocatalytic Proximity Labeling

Aggregate
Golgi apparatus (GA)‐associated secretome runs through the endomembrane system and is critical for inter‐ and intracellular communication networks. However, achieving in situ dissection of the GA‐associated secretome remains challenging owing to the ...
He Wang, Yanli Guo, Zhen Liang, Wenwen Liu, Zijian Guo, Yukui Zhang, Yuncong Chen, Bo Jiang, Lihua Zhang   +8 more
doaj   +1 more source

Gelatin sponge scaffolds loaded with adipose-derived mesenchymal stem cell secretome enhance full-thickness skin wound healing in rats

Social Determinants of Health
Background: Skin wounds that are full-thickness present a major clinical problem. Although cell-based treatments have limitations, the secretome of adipose-derived mesenchymal stem cells (ADMSCs) stimulates recovery through paracrine signaling.
Amir Alesheikh , Tayyeb Ghadimi, Abbas Kazemi Ashtiani , Abolfazl Abbaszadeh   +3 more
doaj   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source