Results 101 to 110 of about 44,866 (298)
Advanced Science, EarlyView.D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen +11 more
wiley +1 more source
A CD14‐Targeting In Situ Hydrogel Directs Macrophage Reprogramming to Minimize Scar Formation
Advanced Science, EarlyView.A CD14‐targeting in situ hydrogel formed from a microbial polysaccharide rapidly remodels the immune microenvironment by reprogramming macrophage polarization, suppressing excessive inflammation, and coordinating tissue regeneration. This multifunctional hydrogel promotes scar‐reduced wound repair through enhanced angiogenesis, collagen remodeling, and
Rui Fang +5 more
wiley +1 more source
Secretome analysis of V. inaequalis.
, 2013 Comparative analysis of secretome sizes of various filamentous fungi (A), showing that the secretome size of V. inaequalis is comparable to other fungi. Gene Ontology (GO) term assignments to V.
Vandna Chawla (103030) +6 more
core +1 more source
Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics
Advanced Intelligent Discovery, EarlyView.A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha +2 more
wiley +1 more source
, 2012 Aims: Early detection of cardiovascular diseases and knowledge of underlying mechanisms is essential. Tissue secretome studies resemble more closely to the in vivo situation, showing a much narrower protein concentrations dynamic range than plasma.
Enrique Calvo +25 more
core +1 more source
Advanced NanoBiomed Research, EarlyView.Intermittent catheter use can damage the urinary tract and predispose to infection. We deployed a complex human urothelial model to investigate. Catheter contact induced compressive and shear stress causing umbrella cell disruption, reduced barrier function, inflammation and increased cell adhesion to the catheter surface.
Nazila V. Jafari, Jennifer L. Rohn
wiley +1 more source
Thrombendarterectomy tissue for secretome production and immunohistochemistry.
, 2012 a) Tissue sample as it was received from the surgical department. b) The tissue was separated into the plaque part (I) for production of the plaque secretome, and the best preserved part (II) for production of the control secretome.
Hans Reiser (126140) +21 more
core +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu +23 more
wiley +1 more source
Biomolecular and Health Science JournalIntroduction: Tendons that are crucial for movement are struggling with self-healing. Regenerative medicine has been using mesenchymal stem cells (MSCs) and their secretomes, and it offers promise.
Agus Kresnadi +3 more
doaj +1 more source
Indicators from archaeal secretomes
Microbiological Research, 2010 Just as in the Eukarya and the Bacteria, members of the Archaea need to export proteins beyond the cell membrane. This would be required to fulfill a variety of essential functions such as nutrient acquisition and biotransformations, maintenance of extracellular structures and more.
Saleh, Mazen +3 more
openaire +2 more sources