Results 111 to 120 of about 46,674 (254)

Challenging the Leukocyte‐Centric Model of Innate Immunity: The Emerging Role of Structural Cells in Immune Defense

iNew Medicine, EarlyView.
Structural cells (endothelial, epithelial, neural, and muscle) actively participate in innate immunity as primary responders, challenging the traditional leukocyte‐centric paradigm and opening new therapeutic avenues for precision medicine. ABSTRACT Innate immunity has long been viewed as the domain of circulating mobile immune cells orchestrating ...
Sofya Urvanova, Suowen Xu
wiley   +1 more source

Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF

Scientific Reports, 2017
Mesenchymal stem cells (MSCs) have been used for cell-based therapies in regenerative medicine, with increasing importance in central and peripheral nervous system repair.
Luís F. Martins, Rui O. Costa, Joana R. Pedro, Paulo Aguiar, Sofia C. Serra, Fabio G. Teixeira, Nuno Sousa, António J. Salgado, Ramiro D. Almeida   +8 more
doaj   +1 more source

Exploring vaginal microbiota–tissue resident stem cell crosstalk: VCAM1/Akt signaling ‐mediated enhancement of regenerative capacity

Interdisciplinary Medicine, EarlyView.
Vaginal microbiota‐derived secretory factors enhance the regenerative capacity of human endometrial stem cells by upregulating VCAM1 and activating PI3K/Akt signaling. This microbiota–stem cell crosstalk promotes self‐renewal, migration, multilineage differentiation, and metabolic reprogramming in vitro and in vivo, establishing a novel microbiota ...
Soo‐Rim Kim, Eun‐Kyung Min, Choon‐Mi Lee, Kun‐Hee Na, Chan Hum Park, YunJae Jung, Hwa‐Yong Lee   +6 more
wiley   +1 more source

Beyond a dual role: how Purpureocillium lilacinum reprograms citrus metabolism for integrated biocontrol and growth promotion

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Plants harbor complex microbial communities that are fundamental to their health and productivity. Among them, endophytic fungi such as Purpureocillium lilacinum establish mutualistic associations, offering dual benefits as plant growth promoters and biocontrol agents.
Sana Bouzembila, Kamel Charaabi, Haytham Hamden, Salma Fadhel, Nesrine Tanfouri, Meriem Msaad Guerfali   +5 more
wiley   +1 more source

Phenolic profile of selected grape (Vitis vinifera L.) varieties in the course of ripening and Botrytis cinerea infections

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Grapevine phenolic compounds play key roles in plant defense and wine quality. Composition depends on factors such as maturity and infections such as grey mold caused by Botrytis cinerea. Grapevines respond to infections by actively modifying their phenolic profile.
Kim Marie Umberath, Louis Backmann, Maren Scharfenberger‐Schmeer, Pascal Wegmann‐Herr, Andreas Schieber, Fabian Weber   +5 more
wiley   +1 more source

Adipose Tissue-Derived Mesenchymal Stem Cells (ADMSCs) and ADMSC-Derived Secretome Expedited Wound Healing in a Rodent Model – A Preliminary Study

Clinical, Cosmetic and Investigational Dermatology, 2021
Hui Ma,1,2 Ping Kuen Lam,3 Wing Sum Siu,1,2 Cindy See Wai Tong,3 Kin Ki Yan Lo,3 Chi Man Koon,1,2 Xiao Xiao Wu,1,2 Xiang Li,1,2 Wen Cheng,1,2 Wai Ting Shum,1,2 Ping Chung Leung1,2 1Institute of Chinese Medicine, The Chinese University of Hong Kong ...
Ma H, Lam PK, Siu WS, Tong CSW, Lo KKY, Koon CM, Wu XX, Li X, Cheng W, Shum WT, Leung PC   +10 more
doaj  

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Dexamethasone marginally surpasses MSC-secretome in resolving acute liver failure in mice

Біологія тварин
The anti-inflammatory roles of Mesenchymal stem cells (MSCs) and glucocorticoids are well-reported in both preclinical and clinical studies. However, it is not clear how far MSC-secretome offers sufficient protection against acute liver failure (ALF ...
Thoria Diab, Eiman M. Adly, Mohamed Hessien   +2 more
doaj   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source

Tumor secretome shapes the immune landscape during cancer progression

The focus of cancer immunotherapy has traditionally been on immune cells and tumor cells themselves, often overlooking the tumor secretome. This review provides a comprehensive overview of the intricate relationship between tumor cells and the immune ...
Jianqiang Yang, Yong Teng, Sijia Tang, Chloe Shay, Nabil F. Saba   +4 more
core   +1 more source