Results 91 to 100 of about 46,674 (254)

Sacral Neural Crest‐Derived Extracellular Vesicles Promote Pelvic Ganglion Repair Through Anti‐Pyroptotic Effects Involving ANXA1–FPR2 Signaling

Advanced Science, EarlyView.
Extracellular vesicles derived from human pluripotent stem cell‐derived sacral neural crest cells promote repair of injured major pelvic ganglia and improve colorectal function. These vesicles reduce oxidative stress and pyroptosis, with ANXA1–FPR2 signaling contributing to their protective effects, and show a favorable therapeutic profile compared ...
Ting Yang, Wenwei Liu, Hufei Wang, Yuxin Wu, Yuanchen Ma, Xiaofeng Wang, Tianxiang Lei, Qiao Tang, Yebohao Zhou, Weiqiang Li, Andy Peng Xiang, Wu Song   +11 more
wiley   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

MACL-1 Breast Cancer Secretome Reprograms Fibroblasts to Enhance Inflammation and Tumor Progression [PDF]

Anais da Academia Brasileira de Ciências
Tumor-secreted factors reprogram the stromal microenvironment to facilitate cancer progression. This study investigates the effects of the MACL-1 breast cancer cell secretome on CCD19-Lu fibroblasts.
RODRIGO JUNIO R. BARROS, ANDREIA LAURA P. RODRIGUES, CAMILA DOURADO, LUCIANA MARIA SILVA, JONAS ENRIQUE A. PERALES, SANDRA LAUTON-SANTOS, ANDREIA BARROSO, JADER S. CRUZ   +7 more
doaj   +1 more source

Astrocyte SMN Restoration and Forskolin Treatment Improve SMA Synaptic Pathology

Annals of Neurology, EarlyView.
Objective Early phenotypic presentation of central afferent synapse dysfunction within patients with spinal muscular atrophy (SMA) represents a key target for therapeutic development; however, the underlying disease mechanisms remain unresolved. By further investigating motor neuron synapse and peri‐synaptic astrocyte process (PAP) defects in human SMA
Emily Welby, Xiaojie Liu, Melinda Wojtkiewicz, Linda Berg Luecke, Rebekah L. Gundry, Qing‐Song Liu, Allison D. Ebert   +6 more
wiley   +1 more source

Distribution of surface, matrix and released (secretome) proteins of the 630Δerm parental strain.

, 2015
* proteins found in the same quantity in the surface proteome of bacteria in biofilm and in biofilm secretome.Distribution of surface, matrix and released (secretome) proteins of the 630Δerm parental strain.
Bryan Roxas (248492), Romain Briandet (74574), Michele Chu (731561), Thomas Candela (74582), Anna Philibertine Soavelomandroso (731560), Anne Collignon (280157), Claire Janoir (531655), Sylvie Bouttier (544363), Véronique Pantaléon (731559), Gayatri Vedantam (248507)   +9 more
core   +1 more source

Additional file 1 of ADSC secretome constrains NK cell activity by attenuating IL-2-mediated JAK-STAT and AKT signaling pathway via upregulation of CIS and DUSP4

, 2023
Additional file 1: Fig. S1. Screening of NK-inhibitory concentrations of the ADSC secretome. Fig. S2. Proteomic and gene ontology (GO) analysis of the ADSC secretome and identification of immunomodulatory candidates within the ADSC ...
Yong-Beom Park (17392632), Yoojin Lee (846133), Jongsun Kim (17392629), Taejun Yoon (10273293), Eunhee Ko (4424353)   +4 more
core   +1 more source

Nanofabricated Biomaterials Model Tumor Extracellular Matrix Topography

Advanced NanoBiomed Research, EarlyView.
The unique structure and composition of the tumor microenvironment and its associated extracellular matrix (ECM) exert profound effects on cancer cell behavior that are difficult to model in vitro. This perspective discusses the utility of nanofabricated biosubstrates, such as the novel collagen‐coated nanogrooved array, for recapitulating the ...
Vic Zamloot, JinSeok Park
wiley   +1 more source

Bioprocessing of Mesenchymal Stem Cells and Their Derivatives: Toward Cell-Free Therapeutics

Stem Cells International, 2018
Mesenchymal stem cells (MSCs) have attracted tremendous research interest due to their ability to repair tissues and reduce inflammation when implanted into a damaged or diseased site.
Jolene Phelps, Amir Sanati-Nezhad, Mark Ungrin, Neil A. Duncan, Arindom Sen   +4 more
doaj   +1 more source

Optimizing Efficacy to Safety Ratio of Glucocorticoids in Rheumatoid Arthritis Models by Leveraging Peroxisome Proliferator–Activated Nuclear Receptor‐α Agonism

Arthritis &Rheumatology, EarlyView.
Objective Glucocorticoids remain essential therapies for immune and inflammatory diseases such as rheumatoid arthritis (RA) but are notorious for their metabolic side effects. Given the anti‐inflammatory and metabolically favorable actions of peroxisome proliferator–activated nuclear receptor (PPAR) agonists, we investigated whether PPARα agonism could
Lisa L. Koorneef, Elisabeth Gilis, Dorien Clarisse, Daria Fijalkowska, Sara Dufour, Julie Coudeneys, Bert Luyckx, Annick Verhee, Jonathan Thommis, Candice Vanden Bussche, Ulf Müller‐Ladner, Elena Neumann, Matthias Kerkhofs, Guillaume Planckaert, Simon Devos, Leander Meuris, Dirk Elewaut, Karolien De Bosscher   +17 more
wiley   +1 more source

Global Secretome Characterization of the Pathogenic Yeast Candida glabrata

, 2020
Secretory proteins are key modulators of host–pathogen interaction. The human opportunistic fungal pathogen Candida glabrata lacks secreted proteolytic activity but possesses 11 glycosylphosphatidylinositol-anchored aspartyl proteases, also referred to ...
Kumar, Naveen, Rasheed, Mubashshir, Kaur, Rupinder   +2 more
core   +1 more source