Results 91 to 100 of about 44,866 (298)

Secretome of Stromal Cancer-Associated Fibroblasts (CAFs): Relevance in Cancer

, 2023
The cancer secretome reflects the assortment of proteins released by cancer cells. Investigating cell secretomes not only provides a deeper knowledge of the healthy and transformed state but also helps in the discovery of novel biomarkers.
Deepshikha Mishra, Debabrata Banerjee
core   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

Bioprocessing of Mesenchymal Stem Cells and Their Derivatives: Toward Cell-Free Therapeutics

Stem Cells International, 2018
Mesenchymal stem cells (MSCs) have attracted tremendous research interest due to their ability to repair tissues and reduce inflammation when implanted into a damaged or diseased site.
Jolene Phelps, Amir Sanati-Nezhad, Mark Ungrin, Neil A. Duncan, Arindom Sen   +4 more
doaj   +1 more source

Concentration of hAdMSC-derived secretome.

, 2015
hAdMSC: human adipose-derived mesenchymal stem cells.Concentration of hAdMSC-derived secretome.
Young-Mo Kim (287055), Hyun-Soo Shin (821092), Hun Jung Kim (821093), Jae-Yol Lim (287044), Hye-Young An (443971), Jeong-Seok Choi (287053)   +5 more
core   +1 more source

Global Secretome Characterization of the Pathogenic Yeast Candida glabrata

, 2020
Secretory proteins are key modulators of host–pathogen interaction. The human opportunistic fungal pathogen Candida glabrata lacks secreted proteolytic activity but possesses 11 glycosylphosphatidylinositol-anchored aspartyl proteases, also referred to ...
Kumar, Naveen, Rasheed, Mubashshir, Kaur, Rupinder   +2 more
core   +1 more source

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

Advanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye, Jiamin Wu, Zixin Wu, Xi Liu, Jiajia Luo, Leyi Yang, Peng Shi   +6 more
wiley   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

Immortalized mammosphere-derived epithelial cells retain a bioactive secretome with antimicrobial, regenerative, and immunomodulatory properties

Stem Cell Research & Therapy
Background The secretome of primary bovine mammosphere-derived epithelial cells (MDECs) has been shown to exert antimicrobial, regenerative, and immunomodulatory properties in vitro, which warrants its study as a potential biologic treatment with the ...
Nikola Danev, Julia M. Poggi, Emilie A. Dewever, Arianna P. Bartlett, Leane Oliveira, Lucas Huntimer, Rebecca M. Harman, Gerlinde R. Van de Walle   +7 more
doaj   +1 more source

Mesenchymal stem cells secretome-induced axonal outgrowth is mediated by BDNF

Scientific Reports, 2017
Mesenchymal stem cells (MSCs) have been used for cell-based therapies in regenerative medicine, with increasing importance in central and peripheral nervous system repair.
Luís F. Martins, Rui O. Costa, Joana R. Pedro, Paulo Aguiar, Sofia C. Serra, Fabio G. Teixeira, Nuno Sousa, António J. Salgado, Ramiro D. Almeida   +8 more
doaj   +1 more source

Mononuclear cell secretome protects from experimental autoimmune myocarditis [PDF]

, 2013
AimsSupernatants of serum-free cultured mononuclear cells (MNC) contain a mix of immunomodulating factors (secretome), which have been shown to attenuate detrimental inflammatory responses following myocardial ischaemia.
Gyöngyösi, Mariann, Hacker, Stefan, Kollmann, Dagmar, Hendrik Jan Ankersmit, Gabriel, Christian, Michael Mildner, Stefan Hacker, Matthias Zimmermann, Balazs Hegedus, Hoetzenecker, Wolfram, Schweiger, Thomas, Dagmar Kollmann, Mildner, Michael, Christian Gabriel, Zimmermann, Matthias, Konrad Hoetzenecker, Blyszczuk, Przemyslaw, Thomas Schweiger, Ankersmit, Hendrik Jan L., Eriksson, Urs, Hegedus, Balazs, Urs Eriksson, Andreas Mitterbauer, Ankersmit, Hendrik Jan, Peter Birner, Hoetzenecker, Konrad, Przemyslaw Blyszczuk, Wolfram Hoetzenecker, Hötzenecker, Konrad, Mitterbauer, Andreas, Birner, Peter, Mariann Gyöngyösi, Pavone-Gyöngyösi, Mariann   +32 more
core   +1 more source