Results 131 to 140 of about 62,112 (253)

A DUF3455 domain‐containing protein promotes Ustilaginoidea virens infection and functions as a plant immune elicitor

New Plant Protection, EarlyView.
The fungal effector UvDUF1 from Ustilaginoidea virens not only promotes infection but also acts as a plant immunity elicitor, inducing broad‐spectrum disease resistance in rice and Nicotiana benthamiana. These results reveal its potential as a novel target for sustainable crop protection strategies.
Shuchen Wang, Wen Zhang, Wenyue Zheng, Qian Zhang, Mina Yu, Junjie Yu, Huijuan Cao, Xiayan Pan, Zhongqiang Qi, Yan Du, Rongsheng Zhang, Yunpeng Wang, Yongfeng Liu, Tianqiao Song   +13 more
wiley   +1 more source

Topical application of a hyaluronic acid-based hydrogel integrated with secretome of human mesenchymal stromal cells for diabetic ulcer repair

Regenerative Therapy
This preclinical proof-of-concept study aimed to evaluate the effectiveness of secretome therapy in diabetic mice with pressure ulcers. We utilized a custom-made hyaluronic acid (HA)-based porous sponge, which was rehydrated either with normal culture ...
Fabio Salvatore Palumbo, Matteo Calligaris, Laura Calzà, Calogero Fiorica, Vito Antonio Baldassarro, Anna Paola Carreca, Luca Lorenzini, Alessandro Giuliani, Claudia Carcione, Nicola Cuscino, Giovanna Pitarresi, Simone Dario Scilabra, Pier Giulio Conaldi, Cinzia Maria Chinnici   +13 more
doaj   +1 more source

SPROUTS_DB: An Implemented Database of Contaminants for Extracellular Vesicle Proteomics Studies

PROTEOMICS, EarlyView.
ABSTRACT Current proteomics techniques allow rapid identification and quantification of proteins within any given biological source. However, LC–MS/MS proteomics is vulnerable to laboratory and sample‐associated contaminants. Therefore, accurate identification and annotation of such contaminants is crucial for development of reliable databases ...
Maria Gaetana Giovanna Pittalà, Loredana Leggio, Greta Paternò, Elena Giusto, Laura Civiero, Vincenzo Cunsolo, Silvia Vivarelli, Antonella Di Francesco, Emanuele Alpi, Nunzio Iraci, Rosaria Saletti   +10 more
wiley   +1 more source

Stem cell–mediated neuroplasticity and psychological recovery in cancer survivors: Mechanisms, evidence, and translational challenges

Precision Medical Sciences, EarlyView.
Cancer therapies can trigger neuroinflammation and disrupted neuroplasticity, contributing to cognitive impairment and psychological distress in survivors. Stem cells (NSCs/MSCs) and their extracellular vesicles may restore neural niches via trophic support, immunomodulation, synaptic remodeling, and vascular repair, but require rigorous safety, dosing,
Xinyi Yang
wiley   +1 more source

Mesenchymal stem cells modulate breast cancer progression through their secretome by downregulating ten-eleven translocation 1

Scientific Reports
Mesenchymal stem cells (MSCs) have emerged as crucial players within the tumor microenvironment (TME), contributing through their paracrine secretome. Depending on the context, the MSC-derived secretome can either support or inhibit tumor growth.
Romina Motamed, Keyvan Jabbari, Mahboubeh Sheikhbahaei, Mohammad H. Ghazimoradi, Sara Ghodsi, Motahareh Jahangir, Neda Habibi, Sadegh Babashah   +7 more
doaj   +1 more source

Capture, Confine, Characterize: High‐Throughput Dielectrophoresis‐Based Single‐Cell Microfluidics Platform to Analyze Mammalian and Yeast Cells Using Raman Spectroscopy

Small, EarlyView.
Traditional single‐cell analysis lacks the capacity for real‐time monitoring. This study presents Microfluidic dielectrophoretic Arresting System (MiDAS), a microelectrofluidic platform using dielectrophoresis for single‐cell and droplet trapping. MiDAS immobilizes diverse samples (cells, beads, droplets) for optical imaging and Raman spectroscopy. Its
Bum‐Joon Jung, Allison Hohreiter, Runjie Chen, Dylan Cook, Linus Hansen, Sunny Taylor, Koseki J. Kobayashi‐Kirschvink, Joseph Chaiken, Supratik Guha, Anindita Basu   +9 more
wiley   +1 more source

Metabolic engineering of adipose‐derived stem cell exosomes via arachidonic acid potentiates diabetic wound repair by orchestrating angiogenesis: A multi‐omics guided strategy

VIEW, EarlyView.
AA‐Exos promotes angiogenesis and accelerates diabetic wound healing by activating the PI3K/AKT/mTOR pathway. Abstract Diabetic wounds are common and challenging complications of diabetes, characterized by delayed healing and an increased risk of infection.
Yujiao Cai, Jinnan Wang, Yan Liu, Xiaoke Zhu, Zhanyuan Yuan, Weiling Li, Dehui Che, Dongsheng Cao   +7 more
wiley   +1 more source

Size-dependent immunomodulation by MSC secretome: soluble factors target innate pathways, components larger than 100 kDa regulate T cell proliferation

Stem Cell Research & Therapy
Background Mesenchymal stromal cells exert their immunoregulatory effects through a complex secretome constituted of soluble factors and extracellular vesicles (EVs).
Christophe Wong, Isaure Rous, Shony Lemieux, Jeanne Volatron, Nassima Bekaddour, Thibaut Fourniols, Jean-Philippe Herbeuval   +6 more
doaj   +1 more source

Proteone and secretome of trypanosomes : A standardised analytical method [PDF]

, 2007
During the infection in mammals, the trypanosomes are known to develop strategies to escape host immune responses that are responsible for the immunopathology.
Brizard, Jean-Paul, Courtois, Pierrette, Cuny, Gérard, Daulouède, Sylvie, Frutos, Roger, Grébaut, Pascal, Holzmuller, Philippe, Vincendeau, Philippe   +7 more
core  

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source