Results 131 to 140 of about 44,866 (298)

Calorie restriction-induced changes in the secretome of human adipocytes, comparison with resveratrol-induced secretome effects

, 2014
Obesity is characterized by dysfunctional white adipose tissue (WAT) that ultimately may lead to metabolic diseases. Calorie restriction (CR) reduces the risk for age and obesity-associated complications.
Renes, J., Noben, J.P., Anja Rosenow, A.R., NOBEN, Jean-Paul, Mariman, E.C., Rosenow, A., Roumans, N., MARIMAN, Edwin C.M.   +7 more
core   +1 more source

Phenolic profile of selected grape (Vitis vinifera L.) varieties in the course of ripening and Botrytis cinerea infections

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Grapevine phenolic compounds play key roles in plant defense and wine quality. Composition depends on factors such as maturity and infections such as grey mold caused by Botrytis cinerea. Grapevines respond to infections by actively modifying their phenolic profile.
Kim Marie Umberath, Louis Backmann, Maren Scharfenberger‐Schmeer, Pascal Wegmann‐Herr, Andreas Schieber, Fabian Weber   +5 more
wiley   +1 more source

ANTIBACTERIAL EFFECTS OF MESENCHYMAL STEM CELL SECRETOME ON THE GROWTH OF PATHOGENIC BACTERIA

Journal of Stem Cell Research and Tissue Engineering
Bacterial infection remains a major global health problem due to the increasing emergence of antibiotic-resistant microorganisms. Mesenchymal stem cell (MSC) secretome has attracted attention as a potential cell-free therapeutic approach because it ...
Parti Putri, Tri Juanda
doaj  

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Growth Factor-Primed WJ-MSC Secretome Enhances Fibroblast Expansion In Vitro

Biomedicines
Background: In regenerative medicine, there is interest in using acellular therapy based on the secretome of mesenchymal stem cells (MSC) to promote wound healing. Wharton’s jelly cells (WJ-MSCs) are a readily available source.
Katia Jarquín-Yáñez, Diana Michel Aguilar-Sandoval, Gabriela Piñón-Zárate, Miguel Angel Herrera-Enríquez, Ivan Daniel Avila-Campos, Beatriz Hernandez-Tellez, Dayana Mayte Dominguez-Diaz, Blanca Esther Blancas-Luciano, Andrés Eliú Castell-Rodríguez   +8 more
doaj   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Golgi Apparatus‐Associated Secretome Deciphering in Living Cells Enabled by Aggregation‐Induced Emission Luminogen‐Mediated Photocatalytic Proximity Labeling

Aggregate
Golgi apparatus (GA)‐associated secretome runs through the endomembrane system and is critical for inter‐ and intracellular communication networks. However, achieving in situ dissection of the GA‐associated secretome remains challenging owing to the ...
He Wang, Yanli Guo, Zhen Liang, Wenwen Liu, Zijian Guo, Yukui Zhang, Yuncong Chen, Bo Jiang, Lihua Zhang   +8 more
doaj   +1 more source

Regenerative Injection Laryngoplasty With Scaffold‐Forming Oligomer and Autologous Motor Endplate‐Expressing Cells: A 6‐Month Porcine Study

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Injection laryngoplasty is a standard‐of‐care intervention for unilateral vocal fold paralysis (UVFP), offering minimally invasive medialization with limited durability. We evaluated a regenerative injectable approach integrating an immunotolerant scaffold‐forming collagen (Oligomer) with autologous motor‐endplate expressing (MEE ...
Gabriel G. Sobczak, Rachel A. Morrison, Lujuan Zhang, Patrick R. Finnegan, Benjamin Johnson, Eric Dong, Bailey Egan, Aditya Bhatt, Sherry L. Voytik‐Harbin, Stacey Halum   +9 more
wiley   +1 more source

Stem cell–mediated neuroplasticity and psychological recovery in cancer survivors: Mechanisms, evidence, and translational challenges

Precision Medical Sciences, EarlyView.
Cancer therapies can trigger neuroinflammation and disrupted neuroplasticity, contributing to cognitive impairment and psychological distress in survivors. Stem cells (NSCs/MSCs) and their extracellular vesicles may restore neural niches via trophic support, immunomodulation, synaptic remodeling, and vascular repair, but require rigorous safety, dosing,
Xinyi Yang
wiley   +1 more source

Topical application of a hyaluronic acid-based hydrogel integrated with secretome of human mesenchymal stromal cells for diabetic ulcer repair

Regenerative Therapy
This preclinical proof-of-concept study aimed to evaluate the effectiveness of secretome therapy in diabetic mice with pressure ulcers. We utilized a custom-made hyaluronic acid (HA)-based porous sponge, which was rehydrated either with normal culture ...
Fabio Salvatore Palumbo, Matteo Calligaris, Laura Calzà, Calogero Fiorica, Vito Antonio Baldassarro, Anna Paola Carreca, Luca Lorenzini, Alessandro Giuliani, Claudia Carcione, Nicola Cuscino, Giovanna Pitarresi, Simone Dario Scilabra, Pier Giulio Conaldi, Cinzia Maria Chinnici   +13 more
doaj   +1 more source