Results 171 to 180 of about 62,112 (253)

Secretome and Pathway Analysis of Stress Induced Disc Degeneration In Vitro

JOR SPINE, Volume 9, Issue 2, June 2026.
Integrated secretome and phosphoprotein profiling of human nucleus pulposus cells revealed that IL‐1β and TLR2/6 activation induce a shared degenerative program, defined by consistent upregulation of IL‐6, IL‐8, GRO‐α, ICAM‐1, and MMP‐7 and convergence on NF‐κB/AP‐1 signaling.
Exarchos Kanelis, Andrea Nüesch, Joseph Snuggs, Christine Lyn Le Maitre, Leonidas G. Alexopoulos   +4 more
wiley   +1 more source

Structural diversity of lipid A modulates neutrophil proteome and secretome responses. [PDF]

J Proteomics
Pittaluga Villarreal JR, Kim D, Yoon SH, Bhushan V, Issara-Amphorn J, Pederson J, Manes NP, Nita-Lazar A.   +7 more
europepmc   +1 more source

A Network‐Based Approach to Understanding Key Signaling Pathways in Intervertebral Disc Biology

JOR SPINE, Volume 9, Issue 2, June 2026.
A literature‐based signaling network capturing the most relevant pathways in human nucleus pulposus cells was first constructed from curated biological evidence. The network was then translated into a system of ordinary differential equations to derive steady‐state solutions and define median baseline activity levels.
Sofia Tseranidou, Zerihun G. Workineh, Maria Segarra‐Queralt, Francis Kiptengwer Chemorion, Paola Bermudez‐Lekerika, Exarchos Kanelis, Katherine B. Crump, Benjamin Gantenbein, Leonidas G. Alexopoulos, Christine L. Le Maitre, Janet Piñero, Jérôme Noailly   +11 more
wiley   +1 more source

Autologous Blood Clot Therapy for Wounds: Investigating the Chemotactic Effect on PBMCs and Fibroblasts in Diabetes. [PDF]

Wound Repair Regen
Howard K, Dhanraj P, Armstrong K, van de Vyver M.   +3 more
europepmc   +1 more source

The abundance of pollen coat small signaling proteins shows limited convergence between independent selfing transitions in Arabidopsis and Capsella

New Phytologist, Volume 250, Issue 5, Page 3460-3474, June 2026.
Summary In plants, a key example of convergence is the repeated evolution of floral traits associated with the transition from outcrossing to self‐fertilization, often resulting in the ‘selfing syndrome’ (e.g. reduced flower size and loss of scent). However, potentially overlooked changes concern the pollen coat, which plays a role in different aspects
Ömer İltaş, Luciana Salomon, Martin Kovačik, Martin Čertner, Pavel Talacko, Karel Harant, Said Hafidh, Clément Lafon Placette   +7 more
wiley   +1 more source

Isolation of Extracellular Vesicles From Mouse Brown Adipose Tissue Secretome Using Size‐Exclusion Chromatography

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Schematic depicting isolation of extracellular vesicles (EVs) from brown adipose tissue (BAT) and their confirmation and quantification by proteomics analysis. The graphical abstract was created using BioRender.com. ABSTRACT Brown adipose tissue (BAT) is a thermogenic tissue that functions in an endocrine, paracrine, and autocrine manner.
Parth Pardeshi, Daniel Velasquez‐Ramirez, Juan David Salazar‐Gil, Tatiana Cuellar‐Gaviria, Lisa A. Baer, Natalia Higuita‐Castro, Kristin I. Stanford   +6 more
wiley   +1 more source

Adipose-Derived Mesenchymal Stem Cell Secretome for Post-Steroid Hypopigmentation and Skin Atrophy: A Case Report. [PDF]

Case Rep Dermatol Med
Yusharyahya SN, Japranata VV, Novianto E.   +2 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, Volume 16, Issue 5, Page 821-836, May 2026.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, Volume 16, Issue 5, Page 1000-1019, May 2026.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Profiling the secretome: maternal obesity impacts redox and adipogenic signaling during neonatal mesenchymal stem cell adipogenesis. [PDF]

Stem Cells
Bellalta S, Pinheiro-Machado E, Casanello P, Faas M, Plösch T.   +4 more
europepmc   +1 more source