Results 181 to 190 of about 62,112 (253)

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, Volume 13, Issue 25, 4 May 2026.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

Wharton's jelly mesenchymal stem cell-secretome enhances skin rejuvenation via ApoA4 and SERPINH1. [PDF]

Regen Ther
Lee NE, Hwang JI, Bang CY, Kim EH, Bang OY.   +4 more
europepmc   +1 more source

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

In Vivo Evaluation of Preconditioned Adipose‐Derived Stromal Cells Reveals Limited Impact on Vascular and ECM Remodeling in Polymer Scaffolds

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 5, May 2026.
ABSTRACT Polymer scaffolds are a promising platform for the transplantation of insulin‐producing cells in Type 1 Diabetes. While vascularization has been a primary focus due to its role in oxygen and nutrient delivery, the interplay between blood vessels and the extracellular matrix (ECM) is increasingly recognized as critical for establishing a stable
Erika Pinheiro‐Machado, Timara Kuiper, Romy H. Huurman, Arjen H. Petersen, Theo Borghuis, Alexandra M. Smink   +5 more
wiley   +1 more source

Secretome as a novel regenerative strategy for atopic dermatitis: a comprehensive review. [PDF]

Stem Cell Res Ther
Subramaniam P, Shafiee MN, Fadilah NIM, Fauzi MB, Maarof M.   +4 more
europepmc   +1 more source

Extracellular Vesicles in Osteoarthritis: From Pathogenic Mediators to Engineered Therapeutics in a Precision Medicine Roadmap

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Osteoarthritis (OA) remains without disease‐modifying sssstherapies, in part due to biological heterogeneity and a hostile joint microenvironment that undermines one‐size‐fits‐all interventions. Extracellular vesicles (EVs) play a dual role in OA pathophysiology: endogenous EVs disseminate pro‐inflammatory and catabolic signals that propagate ...
Duc‐Hiep Bach, Van Giang Bui, Thanh Liem Nguyen   +2 more
wiley   +1 more source

Expression of BMP-2, OPG, RANKL And Number of Osteoblasts After Application of Bovine Amniotic Membrane and Secretome Umbilical Cord in Wistar Rats. [PDF]

Nanotheranostics
Setiawatie EM, Bargowo L, Supandi SK, Negoro VP, Y P A FDA, K A EL, Agusta R, Baharuddin NA.   +7 more
europepmc   +1 more source

A Syndecan‐Based Genetic Approach to Coat the Surface of Small Extracellular Vesicles With Nanobodies

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Small extracellular vesicles (sEVs) are promising vehicles for targeted therapeutic delivery, but strategies for their surface functionalization remain limited. Here, we present a reliable and simple genetic approach that enables customized modification of sEV surfaces and supports enhanced sEV uptake by recipient cells. This strategy is based
Lukas Hyka, Sofie Meeussen, Rania Ghossoub, Michiel De Coster, Elke De Bruyne, Guido David, Patrick Chames, Pascale Zimmermann   +7 more
wiley   +1 more source

Pro- and Anti-tumorigenic Effects of MSC Secretome in Glioblastoma: Mechanisms and Therapeutic Implications. [PDF]

Stem Cell Rev Rep
Asadpour A, Cottrell GS, Widera D.
europepmc   +1 more source

An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition [PDF]

, 2017
et al,, Vermi, William
core   +1 more source