Results 181 to 190 of about 46,674 (254)

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Effects of Wharton's Jelly Mesenchymal Stem Cell-Derived Secretome on Cell Functions in Human Endometrium. [PDF]

Cells
Doneva S, Belemezova K, Stoycheva V, Bochev I, Timeva T, Yunakova M, Andreeva P, Kavaldzhieva K, Shterev A, Kyurkchiev S.   +9 more
europepmc   +1 more source

The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity

The Journal of Physiology, EarlyView.
Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas, Debbie J. Otto, Daniel Stratton, Katja Rietdorf, Daniel M. Johnson, Calum J. McMullen   +5 more
wiley   +1 more source

Lung tumour secretome and extracellular vesicles: mechanisms, biomarkers, and therapeutic opportunities. [PDF]

Cancer Metastasis Rev
Shimizu K, Xia Y, Cottrell GS, Widera D.
europepmc   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Secreted protein circuits in the gastrointestinal tumour microenvironment: determinants of immunotherapy response and resistance. [PDF]

J Transl Med
Li K, Qian Z, Mao J, Han Y, Leng X.
europepmc   +1 more source

A Behavior‐Integrated Potency Assay for Quantitative Evaluation of Extracellular Matrix Remodeling by Mesenchymal Stem/Stromal Cells

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 2984-2998, November 2026.
ABSTRACT Reliable potency assays are critical for ensuring the therapeutic consistency and manufacturing quality of mesenchymal stem/stromal cells (MSCs). Conventional assays based on soluble factor quantification often fail to capture extracellular matrix (ECM) remodeling capacity and exhibit high variability.
Shao Ying Tan, Mee‐Hae Kim, Masahiro Kino‐oka   +2 more
wiley   +1 more source

Single-Cell and Bulk Transcriptomics Reveal an Epithelial <i>LTF</i>-<i>LRP11</i> Signaling Axis Associated with Severe COVID-19 Susceptibility. [PDF]

Genes (Basel)
Labbate Bonaldo AL, Dos Santos Souza J, Santos Oliveira J, Piveta Schnepper A, Ferreira Mussatto CF, Schimidt Camargo VL, Freire PP, Cabral-Marques O, Cury SS, Carvalho RF.   +9 more
europepmc   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3079-3105, November 2026.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Corrigendum to "Human umbilical cord mesenchymal stem cells secretome and nanoemulsion propolis combination ameliorate osteoclastogenesis in lipopolysaccharide-induced osteolysis in hyperglycemia rats" [J Dent Sci] 20 (2025) 2181-2188. [PDF]

J Dent Sci
Nugraha AP, Yang K, Pramusita A, Putranti NAR, Luthfi M, Ramadhani NF, Sitalaksmi RM, Situmorang PC, Ade Artasasta M, Alhasyimi AA, Riawan W, Nugraha AP, Shariff KA, Tanimoto K, Hong G.   +14 more
europepmc   +1 more source