Results 191 to 200 of about 46,674 (254)

Articular Cartilage‐Derived Extracellular Matrix Material Promotes a Pro‐Regenerative Macrophage Phenotype to Support Chondrogenesis

Journal of Biomedical Materials Research Part A, Volume 114, Issue 11, November 2026.
ABSTRACT Articular cartilage (AC) repair remains a major clinical challenge due to its limited healing capacity and the inability of current treatment strategies to restore long‐term function. Biomaterial‐based strategies which support favorable immune responses and appropriate progenitor cell function have shown promise in enhancing cartilage ...
Sinead A. O'Rourke, Giovanni Gonnella, Gabriela S. Kronemberger, Stéphane Petrousek, David A. Hoey, Aisling Dunne, Daniel J. Kelly   +6 more
wiley   +1 more source

Large-Scale Production of Secretome From Human Dental Pulp Stem Cells for Articular Cartilage Regeneration. [PDF]

Stem Cells Int
Bravo-Baranda L, Milián L, Sancho-Tello M, Llop-Miguel M, Monleón-Guinot I, Martínez-Ramos C, Morales-Tatay JM, Mínguez-Rey MF, Mata M.   +8 more
europepmc   +1 more source

Exosomes in Cancer: The Biology, Function, Diagnosis, and Therapy

MedComm, Volume 7, Issue 11, November 2026.
Tumor‐derived exosomes and nonmembranous extracellular nanoparticles (exomeres/supermeres) constitute a heterogeneous communication network that drives cancer progression. By shuttling functional biomolecules across tissue‐specific barriers, these nanoparticles orchestrate local microenvironmental remodeling, immune suppression, premetastatic niche ...
Jun Wu, Lei Wu, Kang Yang, Kang Xie, Tao Lu, Tiangxiang Huang, Dengfeng Wan, Tao Song, Longbo Zhang   +8 more
wiley   +1 more source

Engineering Next-Generation Wound Gels for Advanced Healing. [PDF]

Gels
Narayanan KB.
europepmc   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, Volume 46, Issue 6, Page 1897-1921, November 2026.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Severe Adult Kerion Celsi With Rapid Improvement During Systemic Antifungal and Adjunctive Secretome Therapy: A Case Report. [PDF]

Cureus
Dewi DAR, Tasya K, Firdaus J, Maulida S, Murtiyani S.   +4 more
europepmc   +1 more source

Senescent Mesenchymal Stromal Cells Drive Stem Cell Aging Through Dysregulated Chemokine Synthesis

Aging Cell, Volume 25, Issue 11, November 2026.
Senescent MSCs do more than fuel inflammaging: they disrupt the chemokine signals that maintain stem cell function. We propose that restoring this signaling balance through senolytics, senomorphics, or MSC rejuvenation may preserve regenerative capacity during aging. ABSTRACT Aging is accompanied by a progressive decline in tissue regenerative capacity,
Shaianne N. Stein, Lorena R. Braid
wiley   +1 more source

Impact of secretome containing extracellular vesicles from human induced pluripotent stem cell-derived cardiomyocytes. [PDF]

Regen Ther
Saito Y, Takemura K, Aoyama J, Hibino S, Hasegawa K, Sawa Y.   +5 more
europepmc   +1 more source

Metabolic Profiling of Circulating and Tumour‐Infiltrating T Cells Uncovers Bioenergetic Checkpoints Linked With Immune and Clinical Skewing in Melanoma Patients

Immunology, Volume 179, Issue 3, Page 486-515, November 2026.
In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque, Kareem Mahdy, Stephane Mouret, Sylvain Henry, Camille Niveau, Mélanie Cettour‐Cave, Martin Pelosse, Florence de Fraipont, Julie Charles, Andrei Turtoi, Philippe Saas, Caroline Aspord   +11 more
wiley   +1 more source

Quantum molecular resonance and secretome synergistically unlocks a protective ceRNA axis in the human retinal pigment epithelium. [PDF]

Mol Ther Nucleic Acids
Alibrandi S, Mordà D, Scimone C, D'Ascola A, Aliquò F, Abate G, Pozzato G, Scalinci SZ, D'Angelo R, Sidoti A, Donato L.   +10 more
europepmc   +1 more source