Results 211 to 220 of about 44,866 (298)

Tissue Damage in Rheumatoid Arthritis Is Genetically Linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts

Arthritis &Rheumatology, Volume 78, Issue 9, Page 1837-1849, September 2026.
Objective Both susceptibility to, and severity of, rheumatoid arthritis (RA) is associated with the rs26232 C allele. Our primary aim was to identify the biologic mechanism underlying this association. Methods Expression of surrounding genes was compared among rs26232 genotypes.
Kevin J. Sheridan, Emma R. Dorris, Maria Inês Pimenta, Jemma Falkov, Matthew Fisher, Sam Pledger, Hector Devey, Munitta Muthana, Denis C. Shields, Richard E. Mains, Betty A. Eipper, Christopher D. Buckley, Anthony G. Wilson   +12 more
wiley   +1 more source

Fostering Regeneration and Functional Improvement in the Injured Spinal Cord by a Novel, Stem Cell Secretome-Based Drug Delivery Method. [PDF]

Pharmaceutics
Fekécs Z, Pajer K, Bellák T, Török D, Táncos Z, Nemes C, Gál L, Kobolák J, Dinnyés A, Nógrádi A.   +9 more
europepmc   +1 more source

UTMD Suppresses CSF‐1 to Drive Macrophage‐Mediated Ferroptosis in Papillary Thyroid Carcinoma

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT The tumor microenvironment (TME) of Papillary Thyroid Carcinoma (PTC), particularly the role of tumor‐associated macrophages (TAMs), contributes to therapeutic resistance. This study investigated whether ultrasound‐targeted microbubble destruction (UTMD), a non‐invasive physical modality, could reprogram the TME through modulation of TAMs and ...
Yanqiang Niu, Zhenqiang Yao, Minghua Zhang, Jiayan Zhang, Yushan Li, Jinhui Xie, Zubang Zhou   +6 more
wiley   +1 more source

Intra-articular injection of allogeneic canine adipose-derived stem cell enriched secretome in dogs undergoing tibial plateau leveling osteotomy: a prospective double-blind and randomized pilot trial. [PDF]

Vet Res Commun
Carrera ALC, Minto BW, Alcântara BM, Previtali DAC, Faustino RCS, Tavares ABL, Doiche DP, Nogueira C, Brunel HSS, Pereira RW, Alievi MM, Dias LGGG, Malard PF.   +12 more
europepmc   +1 more source

Chronic Paraquat Neurotoxicity and Dopaminergic Degeneration: A Mechanistic Review

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Occurrence of Parkinson's disease (PD) based on several neurotoxins. Advanced and comprehensive mechanisms based on Paraquat‐induced PD. Mechanism of oxidative stress, ROS and RNS formation, and death of dopaminergic neurons. The modulation of genes and proteins by paraquat leads to Parkinsonism.
Saima Riaz, Shaukat Ali, Muhammad Summer, Amina Iqbal, Rimsha Ashraf, Ramzana Bibi   +5 more
wiley   +1 more source

Lipid-Induced Endothelial Dysfunction: Pro-Atherogenic Properties of Multinucleated Variant Endothelial Cells. [PDF]

Int J Mol Sci
Cherednichenko V, Kiseleva D, Khovantseva U, Ziganshin R, Fotin D, Zakharova E, Dymova O, Markin AM.   +7 more
europepmc   +1 more source

Rapid normal fibroblast‐tumor crosstalk promotes cancer‐associated fibroblast‐like activation and attenuates mitomycin C cytotoxicity in bladder cancer

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Normal bladder fibroblasts rapidly engage in bidirectional crosstalk with bladder cancer cells, acquiring cancer‐associated fibroblast‐like activation features while promoting wound closure, epithelial‐mesenchymal transition‐like cadherin remodeling, and reduced mitomycin C‐induced cytotoxicity.
Jinhui Gao, Cindy Xinyu Ji, Ci Ren, John Hines, Eleanor Stride, Richard T. Bryan, Jennifer L. Rohn   +6 more
wiley   +1 more source

Adjunctive topical mesenchymal stem cell-derived secretome-enriched biological dressings in pediatric complex wounds: a retrospective case series. [PDF]

Front Med (Lausanne)
García-Lira JR, Valencia-Herrera AM, Toledo-Bahena ME, Mena-Cedillos CA, Chávez-López A.   +4 more
europepmc   +1 more source

Mechanobiological feedback loops and quantitative decision thresholds in organ fibrosis: Translational principles for antifibrotic therapy

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Multiorgan fibrosis arises when chronic injury activates fibroblasts and remodels extracellular matrix, whose increasing stiffness sustains disease through mechanotransduction pathways. Bidirectional cellular‐matrix feedback operates across lung, heart, liver, and kidney.
Amedeo Lonardo, Ralf Weiskirchen
wiley   +1 more source

A Conserved Lignocellulolytic Secretome with Quantitative Modulation in <i>Leucoagaricus gongylophorus</i>, the Mutualistic Fungus of Leaf-Cutting Ants. [PDF]

Mycobiology
Cejas-Añón G, Castillo-Alfonso F, Carrasco-Navarro U, Valenzuela-González J, Olivares-Hernández R, Vigueras-Ramírez G.   +5 more
europepmc   +1 more source