Results 221 to 230 of about 46,674 (254)

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, Volume 13, Issue 60, 28 October 2026.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, Volume 13, Issue 58, 19 October 2026.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, Volume 13, Issue 58, 19 October 2026.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, Volume 13, Issue 58, 19 October 2026.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Modeling Catheter‐Associated Bladder Mucosal Adhesion and Microtrauma Using a Human Urothelial Microtissue Model

Advanced NanoBiomed Research, Volume 6, Issue 10, October 2026.
Intermittent catheter use can damage the urinary tract and predispose to infection. We deployed a complex human urothelial model to investigate. Catheter contact induced compressive and shear stress causing umbrella cell disruption, reduced barrier function, inflammation and increased cell adhesion to the catheter surface.
Nazila V. Jafari, Jennifer L. Rohn
wiley   +1 more source

Epicardial Adipose Tissue as a Dynamic Modulator of Coronary Artery Disease Phenotypes: Pathophysiology and Therapeutic Implications

Clinical Cardiology, Volume 49, Issue 10, October 2026.
Epicardial adipose tissue (EAT) may contribute to the heterogeneous pathophysiology of coronary artery disease (CAD) through interconnected inflammatory, metabolic, and paracrine mechanisms. This review integrates EAT biology across CAD phenotypes and examines therapeutic strategies that may modulate EAT, highlighting current evidence and key gaps in ...
Seyed Amirhossein Dormiani Tabatabaei, Mehrnazsadat Dormiani Tabatabaei   +1 more
wiley   +1 more source

Stem Cell and EV/sEV Strategies for Neuroimmune Niche Reprogramming in Selected CNS Disorders: Mechanisms, Engineered Delivery, and Translational Readiness

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Stem cell‐ and EV/sEV‐based interventions may reprogram the CNS neuroimmune niche by suppressing glial inflammation, enhancing trophic and synaptic support, stabilizing BBB communication, and improving metabolic resilience. Clinical translation will require mechanism‐linked potency assays, MISEV‐aligned EV reporting, biodistribution, GMP manufacturing,
Wenjing Lu, Junqiang Yan, Hongfang Feng
wiley   +1 more source

Exercise Modulates the Osteoimmune Axis: Myokine‐Mediated Mechanisms in Diabetic Bone Disease

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 7, October 2026.
Exercise activates skeletal muscle to release myokines (irisin, acute IL‐6, IL‐15 and BAIBA) and suppress myostatin, which may help counteract T2DM‐induced hyperglycemia, AGE accumulation, chronic inflammation and osteoimmune imbalance, potentially contributing to improved bone quality and reduced fracture risk.
Chao Wu, Jun Zou, Yu Yuan
wiley   +1 more source

Pre-Conditioned Bone Marrow Mesenchymal Stromal Cell-Derived Secretome Exerts an Anti-Inflammatory Effect on Degenerative Nucleus Pulposus Cells In Vitro. [PDF]

JOR Spine
Tilotta V, Vadalà G, Ambrosio L, Di Giacomo G, Cicione C, Russo F, Papalia R, Denaro V.   +7 more
europepmc   +1 more source