Results 231 to 240 of about 44,866 (298)

Collecting Eggs, Not Killing Chickens: Why Stem Cell Secretome and Exosomes Are Redefining Regenerative Medicine for Healthspan Extension. [PDF]

Biomedicines
Dangerfield JA, Metzner C.
europepmc   +1 more source

Calpeptin Reduces Extracellular Vesicle Secretion and Induces Anti‐Inflammatory Effects but Upregulates HO‐1 and Alters Adiponectin Levels in Human Adipocytes

Journal of Extracellular Biology, Volume 5, Issue 9, September 2026.
ABSTRACT Recent studies have shown that adipose tissue (AT) secretes elevated levels of extracellular vesicles (EVs) in obesity, and these EVs play roles in metabolic diseases. The inhibition of calpains has anti‐inflammatory and anti‐fibrotic effects on AT in mice and reduces EV secretion in some cell types in vitro.
Johanna Matilainen, Sanni Foster, Viivi Berg, Janne Tampio, Tanja Turunen, Anne‐Mari Mustonen, Heikki Kyykallio, Maija Vaittinen, Ville Männistö, Jussi Pihlajamäki, Marjo Malinen, Sanna Oikari, Pirjo Käkelä, Dorota Kaminska, Veera Luukkonen, Kristiina M. Huttunen, Martin Wabitsch, Petteri Nieminen, Kirsi Rilla   +18 more
wiley   +1 more source

The Myokine Adaptome in Health and Disease: Exercise-Induced Cellular Signaling, Muscle-Organ Crosstalk, and Therapeutic Plasticity. [PDF]

Cells
Mănescu DC, Plastoi CD, Pîrvan A, Dîrnu R, Floroiu EA, Popescu A.   +5 more
europepmc   +1 more source

Surviving the Nucleus Pulposus Desert: Next‐Generation Strategies for Intervertebral Disc Cell Therapy

JOR SPINE, Volume 9, Issue 3, September 2026.
ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes.
Tynhinane Hamidouche, Namdev More, Tiffany Lee, Mia Orr, Anne Camus, Devina Purmessur, Sarah E. Gulbrand, Nadeen O. Chahine, Lara Silverman, Dmitriy Sheyn   +9 more
wiley   +1 more source

Mesenchymal Stem Cell-Based Therapy for Cerebellar Ataxia: From Bench to Bedside. [PDF]

CNS Neurosci Ther
Suk K, Lee HW, Kim SR.
europepmc   +1 more source

Stromal Cell‐Derived Factor‐1α (SDF‐1α)‐Gene Activated Scaffold and Angiogenesis Process in Tissue Engineering: A Systematic Review and Meta‐Analysis of in Vitro Studies

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The current systematic review revealed that stromal cell‐derived factor‐1α (SDF‐1α)‐gene‐activated scaffolds have a beneficial impact on promoting SDF‐1α gene expression and protein production. However, this effect is not observed for vascular endothelial growth factor (VEGF) gene expression and protein quantity and endothelial formation, which may be ...
Tungki Pratama Umar, Dessy Agustini, Sandy Hasan, Rohan Sabloak   +3 more
wiley   +1 more source

EMILIN1 emerges as a TGFβ/SETDB1-regulated secreted biomarker in Duchenne muscular dystrophy. [PDF]

Cell Death Dis
Zamperoni M, Muraine L, Tran MY, Granados A, Bigot A, Petit V, Bensalah M, Ohana J, Legros V, Boyarchuk E, Bruce J, Chevreux G, Joliot V, Negroni E, Moulin M, Trollet C, Ait-Si-Ali S.   +16 more
europepmc   +1 more source

Inflammatory Bowel Disease: Mechanisms and Therapeutic Advances

MedComm, Volume 7, Issue 9, September 2026.
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a rising, multifactorial chronic disorder driven by dysregulated mucosal immunity in genetically susceptible individuals and influenced by environmental and microbial factors.
Andrea Papait, Anna Cargnoni, Franco Scaldaferri, Loris Lopetuso, Antonietta Rosa Silini, Ornella Parolini   +5 more
wiley   +1 more source

Multi-omics integration reveals convergent extracellular matrix remodelling and lipid metabolic reprogramming as central axes of adipocyte differentiation from mouse embryonic stem cells. [PDF]

Adipocyte
Al-Sayegh M, Khalili M, Alzaabi M, Sultana M, Ali L, Ali M, El-Hadidi M.   +6 more
europepmc   +1 more source

Applications of Mesenchymal Stromal Cells for Treatment of Diseases

MedComm, Volume 7, Issue 9, September 2026.
This schematic summarizes the major therapeutic mechanisms of MSCs across different disease systems and highlights factors associated with MSCs dysfunction, together with current strategies to enhance MSCs function and therapeutic efficacy. This summary diagram illustrates that MSCs exert therapeutic effects in various diseases through multiple ...
Dongmei Xue, Yongsheng Li, Lei Wu
wiley   +1 more source