Results 11 to 20 of about 44,866 (298)
Plant secretome proteomics [PDF]
Frontiers in Plant Science, 2013 The plant secretome refers to the set of proteins secreted out of the plant cell into the surrounding extracellular space commonly referred to as the apoplast. Secreted proteins maintain cell structure and acts in signaling and are crucial for stress responses where they can interact with pathogen effectors and control the extracellular environment ...
Alexandersson, Erik +3 more
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Molecular Mechanisms Responsible for Therapeutic Potential of Mesenchymal Stem Cell-Derived Secretome [PDF]
Cells, 2019 Mesenchymal stem cell (MSC)-sourced secretome, defined as the set of MSC-derived bioactive factors (soluble proteins, nucleic acids, lipids and extracellular vesicles), showed therapeutic effects similar to those observed after transplantation of MSCs ...
Harrell C. +14 more
core +4 more sources
The cancer secretome: a reservoir of biomarkers [PDF]
Journal of Translational Medicine, 2008 Abstract Biomarkers are pivotal for cancer detection, diagnosis, prognosis and therapeutic monitoring. However, currently available cancer biomarkers have the disadvantage of lacking specificity and/or sensitivity. Developing effective cancer biomarkers becomes a pressing and permanent need.
Lu Bingjian, Xue Hua, Lai Maode
openaire +5 more sources
VerSeDa: vertebrate secretome database [PDF]
Database, 2017 Based on the current tools, de novo secretome (full set of proteins secreted by an organism) prediction is a time consuming bioinformatic task that requires a multifactorial analysis in order to obtain reliable in silico predictions. Hence, to accelerate this process and offer researchers a reliable repository where secretome information can be ...
Ana Rosa Cortázar +3 more
openaire +7 more sources
Stem cells: Insights into the secretome
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013 Stem cells have been considered as possible therapeutic vehicles for different health related problems such as cardiovascular and neurodegenerative diseases and cancer. Secreted molecules are key mediators in cell-cell interactions and influence the cross talk with the surrounding tissues.
Makridakis, Manousos +2 more
core +5 more sources
Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke-Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling. [PDF]
Adv Sci (Weinh)Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Seong KJ +8 more
europepmc +2 more sources
Dual-Organelle Secretome Conjugation and Organ-Uptake Tracking (DuO-SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins. [PDF]
Adv Sci (Weinh)A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Yang F +7 more
europepmc +2 more sources
Physoxia alters human mesenchymal stem cell secretome [PDF]
, 2021 The human mesenchymal stem cell (hMSC) secretome has pleiotropic effects which underpin their therapeutic potential. hMSC serum-free conditioned media (SFCM) has been determined to contain a variety of cytokines with roles in regeneration and suppression
core +1 more source
Secretome-based proteomics reveals sulindac-modulated proteins released from colon cancer cells
, 2021 Although experiments in rodents and human population-based studies have demonstrated the efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac in colorectal cancer (CRC) prevention, a detailed knowledge of the underlying mechanism of
Richard Simpson (9487685) +4 more
core +1 more source
Proteomic Profiling of the Human Fetal Multipotent Mesenchymal Stromal Cells Secretome
Molecules, 2020 Secretome of multipotent mesenchymal stromal cells (MSCs) is actively used in biomedical applications such as alveolar bone regeneration, treatment of cardiovascular disease, and neurodegenerative disorders.
Arseniy A. Lobov +6 more
doaj +1 more source