Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling [PDF]
Advanced ScienceIschemic stroke induces oxidative stress, neuroinflammation, neuronal death, and synaptic dysfunction, leading to persistent motor and cognitive deficits.
Kyung‐Joo Seong +8 more
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Acoustofluidic Interfaces for the Mechanobiological Secretome of MSCs
Nature Communications, 2023 While mesenchymal stem cells (MSCs) have gained enormous attention due to their unique properties of self-renewal, colony formation, and differentiation potential, the MSC secretome has become attractive due to its roles in immunomodulation, anti ...
Ye He +13 more
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Effects of secretome on cisplatin-induced testicular dysfunction in rats [PDF]
Veterinary World, 2018 Background: Testicular dysfunction is a degenerative disorder characterized by failure in the synthesis of reproductive hormones and spermatogenesis. Secretome derived from the human umbilical mesenchymal stem cell (MSC) has been reported to repair some ...
Surya Agus Prihatno +6 more
doaj +3 more sources
Contribution of Extracellular Membrane Vesicles To the Secretome of Staphylococcus aureus.
MBio, 2023 The microbial secretome modulates how the organism interacts with its environment. Included in the Staphylococcus aureus secretome are extracellular membrane vesicles (MVs) that consist of cytoplasmic and membrane proteins, as well as exoproteins, some ...
Jean C. Lee
exaly +3 more sources
The Secretome of iPSC-Derived Mesenchymal Stem Cells Alters Glial and Vascular Responses in SCI-Relevant Paradigms [PDF]
BiomoleculesCell-free therapies based on the mesenchymal stem cells (MSCs) secretome are being widely explored for spinal cord injury (SCI). Induced pluripotent stem cells (iPSCs) provide a scalable source for generating mesenchymal stem cells (iMSCs), but limited ...
João L. Afonso +15 more
doaj +2 more sources
The tetraspanin CD81 regulates the metastasis-promoting function of the osteosarcoma secretome [PDF]
Biochemistry and Biophysics ReportsOsteosarcoma is a highly aggressive malignancy in which pulmonary metastasis remains the leading cause of mortality. Tumor cell–derived secretome, comprising extracellular vesicles and soluble factors, has been implicated in cancer progression and ...
Yusei Katsuyama +12 more
doaj +2 more sources
Adipose Mesenchymal Stem Cell Secretome Modulated in Hypoxia for Remodeling of Radiation-Induced Salivary Gland Damage. [PDF]
PLoS ONE, 2015 This study was conducted to determine whether a secretome from mesenchymal stem cells (MSC) modulated by hypoxic conditions to contain therapeutic factors contributes to salivary gland (SG) tissue remodeling and has the potential to improve irradiation ...
Hye-Young An +5 more
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Effects of secretome derived from resveratrol treated mesenchymal stem cell on cornea wound: an organ culture study [PDF]
Scientific ReportsThe aim of this study was to improve of therapeutic effects of Adipose-Derived Stem Cells (ADSCs) secretome with Resveratrol (RV) treatment and investigate its effect on corneal wound healing.
Fatemeh Rahimzadeh +6 more
doaj +2 more sources
Dual-Organelle Secretome Conjugation and Organ-Uptake Tracking (DuO-SCOUT) Enables Deep and Sensitive Mapping of the Secreted Proteins. [PDF]
Adv Sci (Weinh)A novel dual‐organelle proximity labeling platform, DuO‐SCOUT, decodes the complex landscape of systemic organ‐organ communication by capturing both classical and unconventional secretomes. Application in metabolic models maps the adipose‐to‐brain secretory relay, identifying selective extra‐hypothalamic sites for adipose‐derived factors and expanding ...
Yang F +7 more
europepmc +2 more sources
The anti-fibrotic effect of human fetal skin-derived stem cell secretome on the liver fibrosis
Stem Cell Research & Therapy, 2020 Background Liver fibrosis resulting from chronic liver injury is one of the major causes of mortality worldwide. Stem cell-secreted secretome has been evaluated for overcoming the limitations of cell-based therapy in hepatic disease, while maintaining ...
Xia Yao +3 more
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