Results 41 to 50 of about 62,112 (253)

Introductory editorial: drug-eluting stents or drug-eluting grafts? Insights from proteomic analysis [PDF]

, 2017
No abstract ...
Al-Attar, Nawwar, Coccia, Raffaella, Di Domenico, Fabio, Nappi, Francesco, Perluigi, Marzia, Spadaccio, Cristiano   +5 more
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Secretome for Cartilage Problems: Is the Current State Enough?

Orthopaedic Journal of Sports Medicine
As the old paradigm of cell-based cartilage treatment has shifted to promising cell-free therapy, the role of secretome has been more profound. To provide the best environment for cartilage regeneration is to provide the most optimum condition and ...
Dwikora Novembri Utomo
doaj   +1 more source

Atrial epicardial adipose tissue abundantly secretes myeloperoxidase and activates atrial fibroblasts in patients with atrial fibrillation

Journal of Translational Medicine, 2023
Background Epicardial adipose tissue (EAT) secretome induces fibrosis. Fibrosis, primarily extracellular matrix (ECM) produced by fibroblasts, creates a substrate for atrial fibrillation (AF).
Eva R. Meulendijks, Rushd F. M. Al-Shama, Makiri Kawasaki, Benedetta Fabrizi, Jolien Neefs, Robin Wesselink, Auriane C. Ernault, Sander Piersma, Thang V. Pham, Connie R. Jimenez, Jaco C. Knol, Wim J. P. van Boven, Antoine H. G. Driessen, Tim A. C. de Vries, Britt van der Leeden, Hans W. M. Niessen, Onno J. de Boer, Sébastien P. J. Krul, Joris R. de Groot   +18 more
doaj   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Genome-wide identification and analysis of a cotton secretome reveals its role in resistance against Verticillium dahliae

BMC Biology, 2023
Background The extracellular space between the cell wall and plasma membrane is a battlefield in plant-pathogen interactions. Within this space, the pathogen employs its secretome to attack the host in a variety of ways, including immunity manipulation ...
Ran Li, Xi-Yue Ma, Ye-Jing Zhang, Yong-Jun Zhang, He Zhu, Sheng-Nan Shao, Dan-Dan Zhang, Steven J. Klosterman, Xiao-Feng Dai, Krishna V. Subbarao, Jie-Yin Chen   +10 more
doaj   +1 more source

Structures of Phytophthora RXLR Effector Proteins: a conserved but adaptable fold underpins functional diversity [PDF]

, 2011
Phytopathogens deliver effector proteins inside host plant cells to promote infection. These proteins can also be sensed by the plant immune system, leading to restriction of pathogen growth.
Adams, Allen, Aminetzach, Armstrong, Bailey, Baxter, Bos, Bos, Bos, Bos, Cowtan, Davis, Demeler, Dodds, Dou, Eddy, Emsley, Evans, Haas, Holm, Jiang, Jones, Karimi, Kearney, Kim, Kobe, Krissinel, Krissinel, Larkin, Leslie, Lindbo, Liu, Markson, McCoy, Nomura, Oh, Potterton, Raffaele, Samanta, Schmidt, Schornack, Schornack, Shan, Sheldrick, Tyler, Vleeshouwers, Whisson, Wierenga, Win, Yang   +49 more
core   +1 more source

Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu, Xi Rui Qiang Lu, Seoyoung Jeong, Douglas H. Wu, Rodrigo A. Somoza, Parameswaran Ramakrishnan, Samuel E. Senyo   +6 more
wiley   +1 more source

Mesenchymal Stem Cell Secretome Attenuates PrP^106-126-Induced Neurotoxicity by Suppressing Neuroinflammation and Apoptosis and Enhances Cell Migration

Cells
Prion diseases are disorders caused by the misfolding of prion protein (PrPSc), leading to the accumulation of an abnormal form of the normal prion protein (PrP) found in the host.
Mohammed Zayed, Byung-Hoon Jeong
doaj   +1 more source

Conditioned Media of Human Umbilical Cord Blood Mesenchymal Stem Cell-derived Secretome Induced Apoptosis and Inhibited Growth of HeLa Cells

Indonesian Biomedical Journal, 2014
BACKGROUND: Secreted factors contained in conditioned media (CM) of human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) known as secretome, was suspected to have important roles in regulating cells.
Ferry Sandra, Janti Sudiono, Elina Ardiani Sidharta, Elisabeth Pricilia Sunata, Dea Jane Sungkono, Yanni Dirgantara, Angliana Chouw   +6 more
doaj   +1 more source