Results 61 to 70 of about 44,866 (298)

Atrial epicardial adipose tissue abundantly secretes myeloperoxidase and activates atrial fibroblasts in patients with atrial fibrillation

Journal of Translational Medicine, 2023
Background Epicardial adipose tissue (EAT) secretome induces fibrosis. Fibrosis, primarily extracellular matrix (ECM) produced by fibroblasts, creates a substrate for atrial fibrillation (AF).
Eva R. Meulendijks, Rushd F. M. Al-Shama, Makiri Kawasaki, Benedetta Fabrizi, Jolien Neefs, Robin Wesselink, Auriane C. Ernault, Sander Piersma, Thang V. Pham, Connie R. Jimenez, Jaco C. Knol, Wim J. P. van Boven, Antoine H. G. Driessen, Tim A. C. de Vries, Britt van der Leeden, Hans W. M. Niessen, Onno J. de Boer, Sébastien P. J. Krul, Joris R. de Groot   +18 more
doaj   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

Determination of optimized oxygen partial pressure to maximize the liver regenerative potential of the secretome obtained from adipose-derived stem cells

Stem Cell Research & Therapy, 2017
Background A hypoxic-preconditioned secretome from stem cells reportedly promotes the functional and regenerative capacity of the liver more effectively than a control secretome.
Sang Chul Lee, Kee-Hwan Kim, Ok-Hee Kim, Sang Kuon Lee, Ha-Eun Hong, Seong Su Won, Sang-Jin Jeon, Byung Jo Choi, Wonjun Jeong, Say-June Kim   +9 more
doaj   +1 more source

Genome-wide identification and analysis of a cotton secretome reveals its role in resistance against Verticillium dahliae

BMC Biology, 2023
Background The extracellular space between the cell wall and plasma membrane is a battlefield in plant-pathogen interactions. Within this space, the pathogen employs its secretome to attack the host in a variety of ways, including immunity manipulation ...
Ran Li, Xi-Yue Ma, Ye-Jing Zhang, Yong-Jun Zhang, He Zhu, Sheng-Nan Shao, Dan-Dan Zhang, Steven J. Klosterman, Xiao-Feng Dai, Krishna V. Subbarao, Jie-Yin Chen   +10 more
doaj   +1 more source

Adipose-Derived Stem Cells Secretome and Its Potential Application in “Stem Cell-Free Therapy”

Biomolecules, 2021
Adipose-derived stem cells (ASCs) secrete many cytokines, proteins, growth factors, and extracellular vesicles with beneficial outcomes that can be used in regenerative medicine.
Anna Trzyna, Agnieszka Banaś-Ząbczyk
doaj   +1 more source

Methodologies to decipher the cell secretome [PDF]

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013
The cell secretome is a collection of proteins consisting of transmembrane proteins (TM) and proteins secreted by cells into the extracellular space. A significant portion (~13-20%) of the human proteome consists of secretory proteins. The secretory proteins play important roles in cell migration, cell signaling and communication.
Paromita, Mukherjee, Sridhar, Mani
openaire   +2 more sources

Inter-species platelet secretome comparisons.

, 2019
Inter-species platelet secretome comparisons.
Signe E. Cremer (7861373), James L. Catalfamo (7861376), Annemarie T. Kristensen (818232), Marjory B. Brooks (3636553), Stefan E. Seemann (7861379), Robert Goggs (276885)   +5 more
core   +1 more source

CD31+ Cell Enrichment Enhances Therapeutic Effects of Stromal Vascular Fraction in Experimental Primary Osteoarthritis: A Preclinical Study in the Dunkin Hartley Guinea Pig Model

Advanced Science, EarlyView.
Both SVF and CD31+ SVF improve spontaneous osteoarthritis, but CD31+ enrichment refines the therapeutic profile rather than broadly enhancing all effects. More distinct benefits are observed in extracellular matrix remodeling, osteochondral integrity, and subchondral/trabecular bone preservation, supporting CD31+‐enriched SVF as a biologically enhanced
Sijia Zhou, Tobias Winkler, Bin Chen, Marta Grzeski, Yilong Yang, Florian N. Fleckenstein, Dominik Geisel, Alexander Hildebrandt, Daniela Aschenbrenner, Marie Agatha Mohn, Benjamin Claass, January Weiner 3rd, Sven Geissler, Georg N. Duda, Søren P. Sheikh, Oliver Klein, Tazio Maleitzke   +16 more
wiley   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

FunSecKB: the Fungal Secretome KnowledgeBase [PDF]

Database, 2011
The Fungal Secretome KnowledgeBase (FunSecKB) provides a resource of secreted fungal proteins, i.e. secretomes, identified from all available fungal protein data in the NCBI RefSeq database. The secreted proteins were identified using a well evaluated computational protocol which includes SignalP, WolfPsort and Phobius for signal peptide or subcellular
Gengkon Lum, Xiang Jia Min
openaire   +2 more sources