Results 61 to 70 of about 46,674 (254)

The cancer secretome: a reservoir of biomarkers [PDF]

, 2008
Biomarkers are pivotal for cancer detection, diagnosis, prognosis and therapeutic monitoring. However, currently available cancer biomarkers have the disadvantage of lacking specificity and/or sensitivity. Developing effective cancer biomarkers becomes a
Lu Bingjian, Hua Xue, Xue Hua, Lai Maode, Bingjian Lu, Maode Lai   +5 more
core   +1 more source

Mesenchymal Stromal Cell‐Based Cell–Drug Conjugates for the Treatment of Acute Liver Failure

Advanced Science, EarlyView.
Mesenchymal stromal cell (MSC)‐based cell‐drug conjugates are constructed by anchoring rosiglitazone‐loaded nanoparticles onto the MSC surface. Sustained rosiglitazone release enhances MSC proliferation and paracrine activity while promoting anti‐inflammatory macrophage polarization.
Tenghui Ye, Jiamin Wu, Zixin Wu, Xi Liu, Jiajia Luo, Leyi Yang, Peng Shi   +6 more
wiley   +1 more source

Genome-wide identification and analysis of a cotton secretome reveals its role in resistance against Verticillium dahliae

BMC Biology, 2023
Background The extracellular space between the cell wall and plasma membrane is a battlefield in plant-pathogen interactions. Within this space, the pathogen employs its secretome to attack the host in a variety of ways, including immunity manipulation ...
Ran Li, Xi-Yue Ma, Ye-Jing Zhang, Yong-Jun Zhang, He Zhu, Sheng-Nan Shao, Dan-Dan Zhang, Steven J. Klosterman, Xiao-Feng Dai, Krishna V. Subbarao, Jie-Yin Chen   +10 more
doaj   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

Leydig cells as a potential target of a drug based on mesenchymal stromal cell secretome in doxorubicin induced toxic damage of spermatogenesis

Acta Biomedica Scientifica
Background. Previously, it has been shown in animal models that the secretome of mesenchymal stromal cells (MSCs) can restore the spermatogonial stem cell niche.
A. O. Mnatsakanyan, N. A. Basalova, G. D. Sagaradze, Liang Yingying, N. V. Nagibin, V. S. Popov, A. Yu. Efimenko   +6 more
doaj   +1 more source

Human secretome proteins not found in dogs.

, 2019
Human secretome proteins not found in dogs.
Signe E. Cremer (7861373), James L. Catalfamo (7861376), Annemarie T. Kristensen (818232), Marjory B. Brooks (3636553), Stefan E. Seemann (7861379), Robert Goggs (276885)   +5 more
core   +1 more source

D4F‐Functionalized Ceria Nanozyme‐CasRx Platform Suppresses STING and Reprograms the Renal Immune Niche in Acute Kidney Injury

Advanced Science, EarlyView.
D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen, Ming Li, Xuesheng Wang, Jiajia Sun, Ziyuan Zhang, Yongfeng Gong, Benkang Shi, Nengwang Yu, Yunuo Mao, Shengtian Zhao, Xiulin Zhang, Liqiang Guo   +11 more
wiley   +1 more source

Determination of optimized oxygen partial pressure to maximize the liver regenerative potential of the secretome obtained from adipose-derived stem cells

Stem Cell Research & Therapy, 2017
Background A hypoxic-preconditioned secretome from stem cells reportedly promotes the functional and regenerative capacity of the liver more effectively than a control secretome.
Sang Chul Lee, Kee-Hwan Kim, Ok-Hee Kim, Sang Kuon Lee, Ha-Eun Hong, Seong Su Won, Sang-Jin Jeon, Byung Jo Choi, Wonjun Jeong, Say-June Kim   +9 more
doaj   +1 more source

Concentration of hAdMSC-derived secretome.

, 2015
hAdMSC: human adipose-derived mesenchymal stem cells.Concentration of hAdMSC-derived secretome.
Young-Mo Kim (287055), Hyun-Soo Shin (821092), Hun Jung Kim (821093), Jae-Yol Lim (287044), Hye-Young An (443971), Jeong-Seok Choi (287053)   +5 more
core   +1 more source

A CD14‐Targeting In Situ Hydrogel Directs Macrophage Reprogramming to Minimize Scar Formation

Advanced Science, EarlyView.
A CD14‐targeting in situ hydrogel formed from a microbial polysaccharide rapidly remodels the immune microenvironment by reprogramming macrophage polarization, suppressing excessive inflammation, and coordinating tissue regeneration. This multifunctional hydrogel promotes scar‐reduced wound repair through enhanced angiogenesis, collagen remodeling, and
Rui Fang, Simeng Chen, Qiaozhen Liu, Wenwen Ni, Xi Xu, Jianfa Zhang   +5 more
wiley   +1 more source