Results 61 to 70 of about 62,112 (253)

Genome Sequence of the Chestnut Blight Fungus Cryphonectria parasitica EP155: A Fundamental Resource for an Archetypical Invasive Plant Pathogen. [PDF]

, 2020
Cryphonectria parasitica is the causal agent of chestnut blight, a fungal disease that almost entirely eliminated mature American chestnut from North America over a 50-year period. Here, we formally report the genome of C. parasitica EP155 using a Sanger
Aerts, Andrea, Barry, Kerrie, Churchill, Alice CL, Crouch, Jo Anne, Dawe, Angus, Grigoriev, Igor V, Grimwood, Jane, Hillman, Bradley I, Milgroom, Michael G, Nuss, Donald L, Pangilinan, Jasmyn, Salamov, Asaf, Schmutz, Jeremy, Smith, Myron, Yadav, Jagjit S   +14 more
core  

Development of 'Redox Arrays' for identifying novel glutathionylated proteins in the secretome [PDF]

, 2015
Proteomics techniques for analysing the redox status of individual proteins in complex mixtures tend to identify the same proteins due to their high abundance.
Bottazzi, Barbara, Chan, Philippe, Ghezzi, Pietro, Hammouz, Raneem, Mullen, Lisa, Seavill, Miles, Vaudry, David   +6 more
core   +1 more source

Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues

Advanced Materials, EarlyView.
A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad, Verena J. Kast, Dagmar Pette, Franziska Baenke, Daniel E. Stange, Carsten Werner, Daniela Loessner   +6 more
wiley   +1 more source

Stem Cell Secretome for Spinal Cord Repair: Is It More than Just a Random Baseline Set of Factors?

Cells, 2021
Hundreds of thousands of people suffer spinal cord injuries each year. The experimental application of stem cells following spinal cord injury has opened a new era to promote neuroprotection and neuroregeneration of damaged tissue.
Krisztián Pajer, Tamás Bellák, Antal Nógrádi   +2 more
doaj   +1 more source

Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants [PDF]

, 2019
Mutations and inadequate methylation profiles of CITED2 are associated with human congenital heart disease (CHD). In mouse, Cited2 is necessary for embryogenesis, particularly for heart development, and its depletion in embryonic stem cells (ESC) impairs
AC Fahed, AC Michell, B Bamforth, B Li, B Xu, BG Bruneau, C-M Chen, CA Eisenberg, D Fraidenraich, D Sabour, ED Cohen, EY Chen, H Mori, H Thomas, I Pacheco-Leyva, J Bakkers, JA Bisson, JA Gaspar, JP Pinto, JPM Barbera, K Meganathan, KR Kranc, M Sahara, M Xu, MV Kuleshov, P Andre, P Choudhry, P Hu, Q Li, S Bhattacharya, S Liu, S Mazzotta, S Sperling, S Ueno, S Zaidi, S-W Cha, SD Bamforth, ST MacDonald, ST MacDonald, T Tan, V Kouskoff, V Wagh, VK Khodiyar, WJ Weninger, Y Liu, Z Yin   +45 more
core   +1 more source

A Reproducible and Scalable Process for High Yield Mesenchymal Stromal Cell Extracellular Vesicles Production

Advanced Materials Technologies, EarlyView.
Mesenchymal stem cell derived extracellular vesicles (MSC‐EVs) are a promising therapeutic tool for regenerative medicine. However, the field lacks a reproducible high‐yield production method to answer the quantities needed for clinical translation.
Christophe Wong, Elise Madec, Jeanne Volatron, Max Piffoux, Amanda K. A. Silva, Florence Gazeau, Jean‐Philippe Herbeuval, Thibaut Fourniols   +7 more
wiley   +1 more source

Kingdom-wide analysis of fungal small secreted proteins (SSPs) reveals their potential role in host association

Frontiers in Plant Science, 2016
Fungal secretome consists of various functional groups of proteins, many of which participate in nutrient acquisition, self-protection, or manipulation of the environment and neighboring organisms.
Ki-Tae eKim, Ki-Tae eKim, Jongbum eJeon, Jongbum eJeon, Jaeyoung eChoi, Jaeyoung eChoi, Kyeongchae eCheong, Kyeongchae eCheong, Hyeunjeong eSong, Hyeunjeong eSong, Gobong eChoi, Gobong eChoi, Seogchan eKang, Yong-Hwan eLee, Yong-Hwan eLee, Yong-Hwan eLee, Yong-Hwan eLee   +16 more
doaj   +1 more source

Sphingosine 1-phosphate receptor 1 is required for MMP-2 function in bone marrow mesenchymal stromal cells: implications for cytoskeleton assembly and proliferation [PDF]

, 2018
Bone marrow-derived mesenchymal stromal cell- (BM-MSC-) based therapy is a promising option for regenerative medicine. An important role in the control of the processes influencing the BM-MSC therapeutic efficacy, namely, extracellular matrix remodelling
Anderloni, Giulia, Chellini, Flaminia, Frati, Alessia, Matteini, Francesca, Meacci, Elisabetta, Nosi, Daniele, Pierucci, Federica, Sassoli, Chiara, Tani, Alessia, Vestri, Ambra, Zecchi-Orlandini, Sandra   +10 more
core   +4 more sources

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing Potential

Advanced Materials Technologies, EarlyView.
Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner, Raith Nowak, Stephanie M. Kronstadt, Nicholas H. Pirolli, Talia J. Solomon, Kristin Nikolov, William Pieper Holeman, Ian M. Smith, Kimberly M. Stroka, John P. Fisher, Steven M. Jay   +10 more
wiley   +1 more source

Additive Manufacturing of Patient‐Specific Intracranial Aneurysm Cell Culture Models

Advanced Materials Technologies, EarlyView.
Patient‐specific intracranial aneurysm models were fabricated using chocolate moulding, 3D printed water‐soluble cores, and direct resin 3D printing. Moulding PDMS around sacrificial cores made of chocolate or 3D printed water‐soluble resin yielded accurate, expandable, and endothelializable models that outperformed resin‐based approaches.
Chloe M. de Nys, Jaimee‐Lee Wood, James I. Novak, Danilo Carluccio, Craig D. Winter, Ashley R. Murphy, Mark C. Allenby   +6 more
wiley   +1 more source