Results 51 to 60 of about 46,674 (254)

Secretome for Cartilage Problems: Is the Current State Enough?

Orthopaedic Journal of Sports Medicine
As the old paradigm of cell-based cartilage treatment has shifted to promising cell-free therapy, the role of secretome has been more profound. To provide the best environment for cartilage regeneration is to provide the most optimum condition and ...
Dwikora Novembri Utomo
doaj   +1 more source

Thrombendarterectomy tissue for secretome production and immunohistochemistry.

, 2012
a) Tissue sample as it was received from the surgical department. b) The tissue was separated into the plaque part (I) for production of the plaque secretome, and the best preserved part (II) for production of the control secretome.
Hans Reiser (126140), Wilibald Maier (126191), Danielle Hof (2282800), Christophe Wyss (126163), Barbara Biedermann (126145), Beatrice Amann-Vesti (58816), Maximilian Y. Emmert (126182), Joanna Gawinecka (126149), Paolo Nanni (126170), Marc Husmann (126186), Arnold von Eckardstein (126197), Roland Klingenberg (126166), Seraina Cooksley-Decasper (126138), Thomas F. Lüscher (126194), Petra Wolint (126178), Gieri Cathomas (126154), Bernd Roschitzki (126174), Christian Matter (126175), Daniela S. Thommen (126142), Michel Neidhart (749), Steffen Gay (754), Fabian C. Franzeck (126159)   +21 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Secretome profiling of human epithelial cells exposed to cigarette smoke extract and their effect on human lung microvascular endothelial cells

Scientific Reports
Cigarette smoke (CS) is one of the leading causes of pulmonary diseases and can induce lung secretome alteration. CS exposure-induced damages to human pulmonary epithelial cells and microvascular endothelial cells have been extensively demonstrated ...
Porrnthanate Seenak, Nitirut Nernpermpisooth, Sarawut Kumphune, Worawat Songjang, Arunya Jiraviriyakul, Noppadon Jumroon, Panyupa Pankhong, Sittiruk Roytrakul, Siriwan Thaisakun, Narumon Phaonakrop, Nitra Nuengchamnong   +10 more
doaj   +1 more source

Mesenchymal Stem Cell Secretome Attenuates PrP^106-126-Induced Neurotoxicity by Suppressing Neuroinflammation and Apoptosis and Enhances Cell Migration

Cells
Prion diseases are disorders caused by the misfolding of prion protein (PrPSc), leading to the accumulation of an abnormal form of the normal prion protein (PrP) found in the host.
Mohammed Zayed, Byung-Hoon Jeong
doaj   +1 more source

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

The bioinformatics pipelines used to predict the F. graminearum secretome.

, 2012
(A) The total secretome and (B) the refine secretome.
John Antoniw (112662), Neil A. Brown (175574), Kim E. Hammond-Kosack (13913)   +2 more
core   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

Atrial epicardial adipose tissue abundantly secretes myeloperoxidase and activates atrial fibroblasts in patients with atrial fibrillation

Journal of Translational Medicine, 2023
Background Epicardial adipose tissue (EAT) secretome induces fibrosis. Fibrosis, primarily extracellular matrix (ECM) produced by fibroblasts, creates a substrate for atrial fibrillation (AF).
Eva R. Meulendijks, Rushd F. M. Al-Shama, Makiri Kawasaki, Benedetta Fabrizi, Jolien Neefs, Robin Wesselink, Auriane C. Ernault, Sander Piersma, Thang V. Pham, Connie R. Jimenez, Jaco C. Knol, Wim J. P. van Boven, Antoine H. G. Driessen, Tim A. C. de Vries, Britt van der Leeden, Hans W. M. Niessen, Onno J. de Boer, Sébastien P. J. Krul, Joris R. de Groot   +18 more
doaj   +1 more source