Results 31 to 40 of about 44,866 (298)

Stem cell secretome derived from human amniotic fluid affords neuroprotection in an ischemic model

Brain Circulation, 2021
Human amniotic fluid stem cells (hAFSCs) are growing in interest; yet, little is understood about their secretome and neuroprotective actions in different diseases, including stroke.
Chase Kingsbury, Liborio Stuppia
doaj   +1 more source

Secretome of adipose-derived mesenchymal stem cells promotes skeletal muscle regeneration through synergistic action of extracellular vesicle cargo and soluble proteins

Stem Cell Research & Therapy, 2019
Background The mechanisms underpinning the regenerative capabilities of mesenchymal stem cells (MSC) were originally thought to reside in their ability to recognise damaged tissue and to differentiate into specific cell types that would replace defective
Robert Mitchell, Ben Mellows, Jonathan Sheard, Manuela Antonioli, Oliver Kretz, David Chambers, Marie-Theres Zeuner, James E. Tomkins, Bernd Denecke, Luca Musante, Barbara Joch, Florence Debacq-Chainiaux, Harry Holthofer, Steve Ray, Tobias B. Huber, Joern Dengjel, Paolo De Coppi, Darius Widera, Ketan Patel   +18 more
doaj   +1 more source

Secretome Proteomic Approaches for Biomarker Discovery: An Update on Colorectal Cancer

Medicina, 2020
Searching for new cancer-related biomarkers is a key priority for the early detection of solid tumors, such as colorectal cancer (CRC), in clinically relevant biological fluids.
Armando Cevenini, Stefania Orrù, Esther Imperlini   +2 more
doaj   +1 more source

Adipose Mesenchymal Extracellular Vesicles as Alpha-1-Antitrypsin Physiological Delivery Systems for Lung Regeneration

Cells, 2019
Accumulating evidence shows that Mesenchymal Stem/Stromal Cells (MSCs) exert their therapeutic effects by the release of secretome, made of both soluble proteins and nano/microstructured extracellular vesicles (EVs).
Elia Bari, Ilaria Ferrarotti, Dario Di Silvestre, Pietro Grisoli, Valentina Barzon, Alice Balderacchi, Maria Luisa Torre, Rossana Rossi, Pierluigi Mauri, Angelo Guido Corsico, Sara Perteghella   +10 more
doaj   +1 more source

The secretome of Staphylococcus aureus strains with opposite within-herd epidemiological behavior affects bovine mononuclear cell response

Veterinary Research, 2023
Staphylococcus aureus modulates the host immune response directly by interacting with the immune cells or indirectly by secreting molecules (secretome).
Susanna Di Mauro, Joel Filipe, Alessia Facchin, Laura Roveri, Maria Filippa Addis, Valentina Monistero, Renata Piccinini, Giulia Sala, Davide Pravettoni, Clarissa Zamboni, Fabrizio Ceciliani, Cristina Lecchi   +11 more
doaj   +1 more source

The Salivary Secretome

, 2023
Recently, proteomics has emerged as an important tool for understanding biological systems, protein–protein interactions, and networks that ultimately lead to a deeper understanding of the underlying mechanisms of certain diseases. More recently, the study of secretomes, a type of proteomics, has also been highlighted as a potential next step in the ...
Luís Perpétuo, Rita Ferreira, Sofia Guedes, Francisco Amado, Rui Vitorino   +4 more
openaire   +2 more sources

Mesenchymal stromal cell-derived exosome-rich fractionated secretome confers a hepatoprotective effect in liver injury

Stem Cell Research & Therapy, 2018
Background Mesenchymal stromal cells (MSCs) are an attractive therapeutic agent in regenerative medicine. Recently, there has been a paradigm shift from differentiation of MSCs to their paracrine effects at the injury site.
Apeksha Damania, Deepika Jaiman, Arun Kumar Teotia, Ashok Kumar   +3 more
doaj   +1 more source

Cell Secretome: Basic Insights and Therapeutic Opportunities for CNS Disorders

Pharmaceuticals, 2020
Transplantation of stem cells, in particular mesenchymal stem cells (MSCs), stands as a promising therapy for trauma, stroke or neurodegenerative conditions such as spinal cord or traumatic brain injuries (SCI or TBI), ischemic stroke (IS), or Parkinson&#
Andreia G. Pinho, Jorge R. Cibrão, Nuno A. Silva, Susana Monteiro, António J. Salgado   +4 more
doaj   +1 more source

MSC Secretome as a Promising Tool for Neuroprotection and Neuroregeneration in a Model of Intracerebral Hemorrhage

Pharmaceutics, 2021
Multipotent mesenchymal stromal cells (MSCs) are considered to be critical contributors to injured tissue repair and regeneration, and MSC-based therapeutic approaches have been applied to many peripheral and central neurologic disorders.
Maxim Karagyaur, Stalik Dzhauari, Nataliya Basalova, Natalia Aleksandrushkina, Georgy Sagaradze, Natalia Danilova, Pavel Malkov, Vladimir Popov, Mariya Skryabina, Anastasia Efimenko, Vsevolod Tkachuk   +10 more
doaj   +1 more source

Targeting the mutant p53 secretome [PDF]

Journal of Clinical Investigation, 2021
While p53 is the most highly mutated and perhaps best studied tumor suppressor protein related to cancer, it remains refractory to targeted therapeutic strategies. In this issue of the JCI, Tan and colleagues investigated the mechanistic basis of the mutant p53 secretome in preclinical models of lung adenocarcinoma.
Kartik Sehgal, David A. Barbie
openaire   +2 more sources