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Regulation of the fungal secretome
Current Genetics, 2016The ability of countless representatives of the Kingdom Fungi to adapt to and proliferate in diverse environments is facilitated by regulation of their secretomes to respond to changes in environmental conditions and to mediate interactions with other organisms.
Sean W, McCotter +2 more
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Hypoxia and the Tumor Secretome
2019Metastasis remains the leading cause of cancer-related deaths. To date, there are no specific treatments targeting disseminated disease. New therapeutic options will become available only if we enhance our understanding of mechanisms underlying metastatic spread.
Ying, Liu +2 more
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Science, 2004
The malaria parasite is a wily pathogen that resides comfortably within its parasitophorous vacuole in the host red blood cell. By skillfully exporting its own proteins across the parasitophorous vacuole membrane into the erythrocyte cytosol and plasma membrane, the malaria parasite ensures a steady supply of nutrients. As Przyborski and Lanzer
Jude Przyborski, Michael Lanzer
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The malaria parasite is a wily pathogen that resides comfortably within its parasitophorous vacuole in the host red blood cell. By skillfully exporting its own proteins across the parasitophorous vacuole membrane into the erythrocyte cytosol and plasma membrane, the malaria parasite ensures a steady supply of nutrients. As Przyborski and Lanzer
Jude Przyborski, Michael Lanzer
openaire +1 more source
Platelets and osteoblasts: secretome connections
American Journal of Physiology-Cell Physiology, 2022Megakaryocyte hyperplasia associated with myeloproliferative neoplasms commonly leads to abnormal bone tissue deposition in the bone marrow, known as osteosclerosis. In this study, we aimed to synthesize the known proteomics literature describing factors released by megakaryocytes and platelets and to examine if any of the secreted factors have a ...
Kerstin Tiedemann +2 more
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Hallmarks of the metabolic secretome
Trends in Endocrinology & MetabolismThe identification of novel secreted factors is advancing at an unprecedented pace. However, there is a critical need to consolidate and integrate this knowledge to provide a framework of their diverse mechanisms, functional significance, and inter-relationships.
Saranya C. Reghupaty +2 more
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Secretomes: The fungal strike force
PROTEOMICS, 2013Microorganisms, although being very diverse because they comprise prokaryotic organisms such as bacteria or eukaryotic organisms such as fungi, all share an essential exodigester function. The consequence is their essential need to have a secretome adapted to their environment.
Vincent, Girard +3 more
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Secretome profiling with antibody microarrays
Molecular BioSystems, 2011Abstract Following the advances in human genome sequencing, attention has shifted in part toward the elucidation of the encoded biological functions. Since proteins are the driving forces behind very many biological activities, large-scale examinations of their expression variations, their functional roles and regulation have moved to
Shakhawan Abdulrahman, Mustafa +2 more
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Bioinformatics tools for secretome analysis
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2013Over recent years, analyses of secretomes (complete sets of secreted proteins) have been reported in various organisms, cell types, and pathologies and such studies are quickly gaining popularity. Fungi secrete enzymes can break down potential food sources; plant secreted proteins are primarily parts of the cell wall proteome; and human secreted ...
Dario, Caccia +3 more
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Secretome of Human Aortic Valves
2013One of the major challenges in cardiovascular medicine is to identify candidate biomarker proteins. Between different proteomics studies, the secretome is a valuable tool in the search for biomarkers locally released by a studied tissue and remains particularly important while working with vascular tissues, since the secreted proteins would be probably
Fernando, de la Cuesta +7 more
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2016
Through rapid advancement of genomics by Next Generation Sequencing (NGS) and proteomics by Mass Spectrometry (MS) technologies and innovative sampling and bioinformatic strategies a new era of personalized medicine is upon us. Secreted proteins play an important role in tumorigenesis through cell growth, migration, invasion, and angiogenesis. As such,
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Through rapid advancement of genomics by Next Generation Sequencing (NGS) and proteomics by Mass Spectrometry (MS) technologies and innovative sampling and bioinformatic strategies a new era of personalized medicine is upon us. Secreted proteins play an important role in tumorigenesis through cell growth, migration, invasion, and angiogenesis. As such,
openaire +1 more source