Results 91 to 100 of about 1,228,008 (299)
Frontiers in Bioengineering and Biotechnology, 2019 Signal peptides are short peptides directing newly synthesized proteins toward the secretory pathway. These N-terminal signal sequences are ubiquitous to all prokaryotes and eukaryotes.
Chong Peng +17 more
doaj +1 more source
The Dynamic Organisation of the Secretory Pathway.
Cell Structure and Function, 1996 The secretory pathway of eukaryotic cells consists of a number of distinct membrane-bound compartments interconnected by vesicular traffic. Each compartment has a characteristic content of proteins and lipids, which must be maintained. This is achieved in most cases by active sorting-proteins may reach the wrong compartment but are continually ...
openaire +3 more sources
Alteration of ZnT5-mediated zinc import into the early secretory pathway affects the secretion of growth hormone from rat pituitary cells [PDF]
, 2014 BACKGROUND Aggregation of growth hormone (GH) required for its proper storage in granules is facilitated by zinc (Zn(2+)) transported by specific zinc transporters in and out of the regulated secretory pathway.
Eblé, Andrée +4 more
core +2 more sources
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
The characterization of adaptor protein homologues in Plasmodium falciparum [PDF]
, 2009 Includes abstract.Includes bibliographical references (leaves 148-171).Plasmodium falciparum is becoming increasingly more resistant to regular antimalarial drugs, making it necessary to identify novel drug candidates and drug targets.
Meredith, Sandra Allison
core +1 more source
Journal of Extracellular VesiclesThe identification of both autophagy‐related material degradation and unconventional secretion has paved the way for significant breakthroughs linking autophagy to a plethora of physiological processes and disease conditions. However, the mechanisms that
Xiaoyu Wei +5 more
doaj +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Membrane trafficking in health and disease
Disease Models & Mechanisms, 2020 Membrane trafficking pathways are essential for the viability and growth of cells, and play a major role in the interaction of cells with their environment.
Rebecca Yarwood +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
A physical mechanism of TANGO1-mediated bulky cargo export
eLife, 2020 The endoplasmic reticulum (ER)-resident protein TANGO1 assembles into a ring around ER exit sites (ERES), and links procollagens in the ER lumen to COPII machinery, tethers, and ER-Golgi intermediate compartment (ERGIC) in the cytoplasm (Raote et al ...
Ishier Raote +6 more
doaj +1 more source