Results 141 to 150 of about 326,424 (312)

The biosynthetic-secretory pathway, supplemented by recycling routes, determines epithelial membrane polarity. [PDF]

Sci Adv, 2023
Zhang N, Zhang H, Khan LA, Jafari G, Eun Y, Membreno E, Gobel V.   +6 more
europepmc   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

The exocyst complex is an essential component of the mammalian constitutive secretory pathway. [PDF]

J Cell Biol, 2023
Pereira C, Stalder D, Anderson GSF, Shun-Shion AS, Houghton J, Antrobus R, Chapman MA, Fazakerley DJ, Gershlick DC.   +8 more
europepmc   +1 more source

Coincident localization of secretory and plasma membrane proteins in organelles of the yeast secretory pathway

, 1988
D Brada, Randy Schekman
openalex   +2 more sources

Induction of secretory pathway components in yeast is associated with increased stability of their mRNA [PDF]

, 2002
Maureen Hyde, Laura Block-Alper, Jahaira Felix, Paul Webster, David I. Meyer   +4 more
openalex   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

TMED10 mediates the trafficking of insulin-like growth factor 2 along the secretory pathway for myoblast differentiation. [PDF]

Proc Natl Acad Sci U S A, 2023
Li T, Yang F, Heng Y, Zhou S, Wang G, Wang J, Wang J, Chen X, Yao ZP, Wu Z, Guo Y.   +10 more
europepmc   +1 more source

Unconventional secretory pathway activation restores hair cell mechanotransduction in an USH3A model [PDF]

, 2019
Suhasini R. Gopal, Yvonne T. Lee, Ruben Stepanyan, Brian M. McDermott, Kumar N. Alagramam   +4 more
openalex   +1 more source

IL‐4/STAT6‐signaling Influences Local Inflammation and Regeneration Processes During Acute Pancreatitis and Promotes Fibrosis by a Direct Activation of Pancreatic Fibroblasts During Chronic Pancreatitis

Advanced Science, EarlyView.
IL‐4/IL‐13/STAT6 signaling plays a crucial for the suppression of pro‐inflammation during acute pancreatitis and supports acinar cell regeneration but has only minor impact on fibrogenesis during chronic form of the disease. IL‐4/IL‐13 induce the expression of certain collagens directly in pancreatic fibroblasts via STAT6 activation, whereas ...
ElSheikh H, Salvers A, Piesker J, Buchholz S, Lange R, Ameling S, Steil L, Hammer E, Homuth G, Völker U, Bröker BM, Weiss FU, Sendler M, Glaubitz J   +13 more
wiley   +1 more source

1-deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway. [PDF]

Cell Chem Biol
Tsai YT, Lipp NF, Seidel O, Varma R, Laguerre A, Solorio-Kirpichyan K, Wong AM, Brea RJ, McGregor GH, Cordes T, Devaraj NK, Kuerschner L, Neal S, Metallo CM, Budin I.   +14 more
europepmc   +1 more source