Results 161 to 170 of about 1,228,008 (299)

HIT A- and B-axes [Secretory pathway; 6b]

, 2014
Presents two movies, HIT A-Axis on the left and HIT B-Axis on the right constitute the Tilt Series datasets from which the tomogram is calculated.
Marsh, Brad J., McIntosh, J. Richard, Howell, Kathryn E.   +2 more
core  

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

TCOF1 affects Golgi secretory pathway contributing to the angiogenesis in renal cancer. [PDF]

Cell Commun Signal
Grzanka M, Popławski P, Wiśniewski JR, Iwanicka-Nowicka R, Kossowska H, Koblowska M, Rybicka B, Białas A, Piekiełko-Witkowska A.   +8 more
europepmc   +1 more source

Author Correction: Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2. [PDF]

Nat Commun, 2023
Nalbach K, Schifferer M, Bhattacharya D, Ho-Xuan H, Tseng WC, Williams LA, Stolz A, Lichtenthaler SF, Elazar Z, Behrends C.   +9 more
europepmc   +1 more source

Liver Endothelia Orchestrate MASH‐Associated Macrophage Zonation Through FSTL1‐ITGA4 Axis

Advanced Science, EarlyView.
Liver inflammation in MASH fundamentally hinges on the newly defined Kit/STAT2/FSTL1/ITGA4 axis. Declining endothelial Kit collapses normal hepatic zonation, driving an aberrant FSTL1 gradient that recruits pathogenic macrophages. Strikingly, targeting FSTL1‐ITGA4 with anti‐VLA4 restores spatial immune homeostasis and halts disease progression ...
Lin Sun, Zhensheng Yue, Zhiqiang Fang, Hao Xu, Wei Du, Yuwei Ling, Jingjing Liu, Ping Song, Fei He, Juanli Duan, Lin Wang   +10 more
wiley   +1 more source

A Nanobody-Based Toolbox to Probe ApoE4 in the Secretory Pathway and Cytosol. [PDF]

Cells
Vandevelde L, Zwaenepoel O, De Bruycker E, Ranson M, Van Stichel C, Matthys C, Gettemans J.   +6 more
europepmc   +1 more source

The biosynthetic-secretory pathway, supplemented by recycling routes, determines epithelial membrane polarity. [PDF]

Sci Adv, 2023
Zhang N, Zhang H, Khan LA, Jafari G, Eun Y, Membreno E, Gobel V.   +6 more
europepmc   +1 more source

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source

Phosphorylation beyond the plasma membrane: How secretory pathway kinases sculpt the cellular dialogue in cancer (Review). [PDF]

Int J Mol Med
Geng Z, Guan S, Du S, Zhang S, Hao J, Tian S, Zhu C, Du S.   +7 more
europepmc   +1 more source

HMGCR‐Driven Cholesterol Metabolism Promotes Osteoarthritis Progression by Accelerating Synovial Fibroblast Senescence

Advanced Science, EarlyView.
In the pathological context of osteoarthritis (OA), the phosphorylation of AKT1 at Ser473 enhances its binding to Lys140 of Insig1, which facilitates the formation of AKT1–Insig1 complex. Subsequently, the activation of AKT1 promotes the phosphorylation of Insig1 at Ser189, potentially enhancing the dissociation of Insig1 from sterol regulatory element‑
Xiaoqi Zhang, Siru Zhou, Xi Liu, Wei Xiang, Xiuqin Peng, Yu Tian, Song Li, Hailin Wang, Bo Liao, Shunzheng Fang, Runze Jin, Jinhui Wu, Chuanqing Bai, Wei Zhang, Bo Huang, Bingfei Li, Lifeng Chen, Lin Chen, Bin Zhang, Zhenhong Ni   +19 more
wiley   +1 more source