Results 171 to 180 of about 1,228,008 (299)

1-deoxysphingolipids dysregulate membrane properties and cargo trafficking in the early secretory pathway. [PDF]

Cell Chem Biol
Tsai YT, Lipp NF, Seidel O, Varma R, Laguerre A, Solorio-Kirpichyan K, Wong AM, Brea RJ, McGregor GH, Cordes T, Devaraj NK, Kuerschner L, Neal S, Metallo CM, Budin I.   +14 more
europepmc   +1 more source

Deconstruction of Human Age‐Related Cataract Capsules Defines Aging

Advanced Science, EarlyView.
We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang, Ziyang Tong, Chunmei Fan, Silong Chen, Jiarui Guo, Jianghua Hu, Ke Yao, Zi Yin, Xiao Chen, Yibo Yu   +9 more
wiley   +1 more source

Coronavirus M protein disperses the trans-Golgi network and inhibits anterograde protein trafficking in the secretory pathway. [PDF]

PLoS Pathog
Caddell TM, Mulloy RP, Corcoran JA, Pringle ES, McCormick C.   +4 more
europepmc   +1 more source

Engineering receptors in the secretory pathway for orthogonal signalling control. [PDF]

Nat Commun, 2022
Mahameed M, Wang P, Xue S, Fussenegger M.   +3 more
europepmc   +1 more source

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

Advanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa, Silke De Vriendt, Lixian Liu, Thalles Fernando Rocha Ruiz, Hugo Vankelecom, Christiani Andrade Amorim   +5 more
wiley   +1 more source

A reconstruction of the mammalian secretory pathway identifies mechanisms regulating antibody production. [PDF]

Cell Syst
Masson H, Tat J, Di Giusto P, Antonakoudis A, Shamie I, Baghdassarian H, Samoudi M, Robinson CM, Kuo CC, Koga N, Singh S, Gezalyan A, Li Z, Movsessian A, Richelle A, Lewis NE.   +15 more
europepmc   +1 more source

Regulation of secretory pathway kinase or kinase-like proteins in human cancers. [PDF]

Front Immunol, 2023
Du S, Zhu C, Ren X, Chen X, Cui X, Guan S.   +5 more
europepmc   +1 more source

Dual axis 3-D reconstructions [Secretory pathway; 6c]

, 2014
Presents movie that demonstrates the complexity of the structures as one moves through the cell volume at approximately 1 nm intervals. The cytoplasm is very dense because the cells were prepared by rapid freezing and freeze substitution, which is ...
Marsh, Brad J., McIntosh, J. Richard, Howell, Kathryn E.   +2 more
core  

Enhancing Super‐Resolution Spatial Transcriptomics Data by Transfer Learning

Advanced Science, EarlyView.
SpotZoomer employs a transfer‐learning‐based strategy to enhance the resolution of Visium data by leveraging available high‐resolution priors. The resulting super‐resolved maps enable sharper delineation of cell boundaries and more precise inference of cell–cell communication patterns that would otherwise remain obscured at native resolution.
Xiaoyu Li, Lihua Zhang, Wenwen Min
wiley   +1 more source

Beyond the Secretory Pathway: New Insights Into Protein Release. [PDF]

Traffic
Chen RH, Costa-Filho AJ, Debnath J, Galli T, Ge L, Goberdhan D, Guo W, He K, Jacob R, Kang T, Lee MG, Li L, Lolicato F, Lu J, Malhotra V, Nickel W, Nikoletopoulou V, Ogden SK, Sagia GM, Shao F, Shi A, Thery C, Vérollet C, Villeneuve J, Verweij F, Wang Y, Wang J, Wu S, Ye Y, Yin H, Yu L, Zhang M, Zhang Y, Zhou X, Zurzolo C.   +34 more
europepmc   +1 more source