Results 181 to 190 of about 1,228,008 (299)

TMED10 mediates the trafficking of insulin-like growth factor 2 along the secretory pathway for myoblast differentiation. [PDF]

Proc Natl Acad Sci U S A, 2023
Li T, Yang F, Heng Y, Zhou S, Wang G, Wang J, Wang J, Chen X, Yao ZP, Wu Z, Guo Y.   +10 more
europepmc   +1 more source

Dual axis 3-D reconstructions [Secretory pathway; 6c]

, 2008
Presents movie that demonstrates the complexity of the structures as one moves through the cell volume at approximately 1 nm intervals. The cytoplasm is very dense because the cells were prepared by rapid freezing and freeze substitution, which is ...
Marsh, Brad J., McIntosh, J. Richard, Howell, Kathryn E.   +2 more
core  

TPI1 Loss Triggers a Metabolite‐Driven Mitochondrial Redox Vulnerability via the SARM1–cADPR–Ca2+ Axis

Advanced Science, EarlyView.
Metabolite‐driven redox stress governs cancer cell senescence. TPI1 deficiency elevates DHAP, initiating SARM1‐dependent cADPR‐Ca2+ release. Mitochondrial ROS surge subsequently induces DNA damage and senescence, offering a conserved therapeutic target in multiple cancers.
Chunyu Liu, Shun Wu, Chuang Wang, Zirui Zhou, Tianwei Cai, Wen Tao, Shidong Zuo, Chi Zhang, Yuhao Dong, Yi Feng, Qingbo Huang, Baojun Wang, Xin Ma, Haoli Ma, Xu Zhang, Yan Huang   +15 more
wiley   +1 more source

A regulatory circuit operated by KDELR1 and KDELR3 fine-tunes the composition of the early secretory pathway. [PDF]

Cell Mol Life Sci
Palazzo FC, Dalla Torre M, Amagai Y, Han X, Tempio T, Valetti C, Manteiga JG, Matsumoto M, Feige M, Sallese M, Inaba K, Sitia R, Anelli T.   +12 more
europepmc   +1 more source

The Early Secretory Pathway Is Crucial for Multiple Aspects of the Hepatitis C Virus Life Cycle. [PDF]

J Virol, 2023
Avula K, Singh B, Samantaray S, Syed GH.
europepmc   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Comprehensive Analysis of the Putative Substratome of FAM20C, the Master Serine Kinase of the Secretory Pathway. [PDF]

Biomolecules
Cesaro L, Noventa F, De Los Angeles Cordero T, Molon B, Bosello Travain V, Aspromonte MC, Salvi M.   +6 more
europepmc   +1 more source

Programmable Nanobody‐Targeting Chimeras Enable Intracellular Viral Protein Degradation

Advanced Science, EarlyView.
Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Max Yu‐Chen Pan, Ting‐Hui Lee, Tzu‐Ning Peng, Eva Yi‐Hsuan Wu, Yu‐Ting Chiu, Chih‐Chien Chiu, Hong Vinh Nguyen, Yuan‐Shao Pao, Ming‐Hong Chao, Richard Kuan‐Lin Lee, Han‐Chung Wu, Lily Hui‐Ching Wang   +11 more
wiley   +1 more source

Brain-Derived Neurotrophic Factor Trafficking via the Regulated Secretory Pathway: Mechanisms and Disease Implications. [PDF]

Mol Neurobiol
Ewell SN.
europepmc   +1 more source

The many hats of transmembrane emp24 domain protein TMED9 in secretory pathway homeostasis. [PDF]

Front Cell Dev Biol, 2022
Roberts BS, Satpute-Krishnan P.
europepmc   +1 more source