Results 151 to 160 of about 1,228,008 (299)

Dual axis 3-D reconstructions [Secretory pathway; 6c]

, 2016
Presents movie that demonstrates the complexity of the structures as one moves through the cell volume at approximately 1 nm intervals. The cytoplasm is very dense because the cells were prepared by rapid freezing and freeze substitution, which is ...
Marsh, Brad J., McIntosh, J. Richard, Howell, Kathryn E.   +2 more
core   +1 more source

Engineering Human Donor Derived Germinal Center‐Like Organoids (GCLOs) for Studying Immune Response to Vaccination

Advanced Science, EarlyView.
We bioengineered a new approach methodology of generating Germinal Center Organoids that self‐organize from human blood‐derived immune cells. These immune organoids reproduce key features of humoral immunity, IgG production, and plasmablast emergence.
Bhumi Suthar, Carlos Gomez, Giancarlo Asencio, Suresh Pallikkuth, Ashutosh Agarwal   +4 more
wiley   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Metalation and activation of Zn²⁺ enzymes via early secretory pathway-resident ZNT proteins. [PDF]

Biophys Rev (Melville), 2023
Kambe T, Wagatsuma T.
europepmc   +1 more source

HIT A- and B-axes [Secretory pathway; 6b]

, 2008
Presents two movies, HIT A-Axis on the left and HIT B-Axis on the right constitute the Tilt Series datasets from which the tomogram is calculated.
Marsh, Brad J., McIntosh, J. Richard, Howell, Kathryn E.   +2 more
core  

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

Identification of Hoiamide A as an Inducer of Oxidative and Endoplasmic Reticulum Secretory Pathway Stress. [PDF]

J Nat Prod
Bonar SE, Mattos DR, Yu X, Neuhaus GF, Youssef DTA, Shaala LA, Gerwick WH, McPhail KL, Ishmael JE.   +8 more
europepmc   +1 more source

Human lipocalins bind and export fatty acids through the secretory pathway of yeast cells. [PDF]

Front Microbiol, 2023
Ekim Kocabey A, Schneiter R.
europepmc   +1 more source

Nanozyme‐Reinforced miR‐197‐3p Delivery Resets Metabolic and Senescence Pathways to Rejuvenate Osteoarthritic Cartilage

Advanced Science, EarlyView.
ABSTRACT Osteoarthritis (OA) is a progressive and disabling joint disease driven by oxidative stress, chondrocyte senescence and extracellular matrix (ECM) degradation, yet lacks effective disease‐modifying treatments. In this study, we identified miR‐197‐3p as a previously unrecognized, cartilage‐protective miRNA significantly downregulated in both ...
Xuejie Cai, Zehui Lv, Chen Zhang, Xingdong Yang, Ruoying Wang, Yixin Bian, Jiawei Xu, Han Wang, Yingjie Wang, Long Bai, Jiacan Su, Xisheng Weng   +11 more
wiley   +1 more source

From EM to AI: Multiscale imaging of the secretory pathway with insights from plant cells. [PDF]

J Microsc
Pain C, Farley E.
europepmc   +1 more source