Results 151 to 160 of about 326,424 (312)

The Early Secretory Pathway Is Crucial for Multiple Aspects of the Hepatitis C Virus Life Cycle. [PDF]

J Virol, 2023
Avula K, Singh B, Samantaray S, Syed GH.
europepmc   +1 more source

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source

A reconstruction of the mammalian secretory pathway identifies mechanisms regulating antibody production. [PDF]

Cell Syst
Masson H, Tat J, Di Giusto P, Antonakoudis A, Shamie I, Baghdassarian H, Samoudi M, Robinson CM, Kuo CC, Koga N, Singh S, Gezalyan A, Li Z, Movsessian A, Richelle A, Lewis NE.   +15 more
europepmc   +1 more source

Regulation of secretory pathway kinase or kinase-like proteins in human cancers. [PDF]

Front Immunol, 2023
Du S, Zhu C, Ren X, Chen X, Cui X, Guan S.   +5 more
europepmc   +1 more source

Saturated Fatty Acids Alter the Late Secretory Pathway by Modulating Membrane Properties [PDF]

, 2013
Laurie-Anne Payet, Ludovic Pineau, Ellen C. R. Snyder, Jenny Colas, Ahmed Moussa, Brigitte Vannier, Joëlle Bigay, Jonathan Clarhaut, Frédéric Becq, Jean‐Marc Berjeaud, Clarisse Vandebrouck, Thierry Ferreira   +11 more
openalex   +1 more source

Acetylation Regulates ACSL4 Degradation Through Chaperone‐Mediated Autophagy to Alleviate Intervertebral Disc Degeneration

Advanced Science, EarlyView.
Intervertebral disc degeneration is triggered by ACSL4 accumulation‐mediated ferroptosis of nucleus pulposus cells due to CMA dysfunction. KAT2B promotes ACSL4 degradation via CMA through acetylation. AAV‐mediated LAMP2A delivery or engineered exosomes rescue nucleus pulposus cell senescence and disc degeneration.
Zhouwei Wu, Zhichen Jiang, Chenglong Hong, Shu Yang, Shuqing Jin, Chenyu Wu, Kaijie Guo, Jiang Liu, Shaobo Xu, Chenggui Wang, Xiangyang Wang   +10 more
wiley   +1 more source

Engineering receptors in the secretory pathway for orthogonal signalling control. [PDF]

Nat Commun, 2022
Mahameed M, Wang P, Xue S, Fussenegger M.   +3 more
europepmc   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

Comprehensive Analysis of the Putative Substratome of FAM20C, the Master Serine Kinase of the Secretory Pathway. [PDF]

Biomolecules
Cesaro L, Noventa F, De Los Angeles Cordero T, Molon B, Bosello Travain V, Aspromonte MC, Salvi M.   +6 more
europepmc   +1 more source

Caspase-resistant Golgin-160 Disrupts Apoptosis Induced by Secretory Pathway Stress and Ligation of Death Receptors

, 2005
Rebecca S. Maag, Marie Mancini, Antony Rosen, Carolyn E. Machamer   +3 more
openalex   +1 more source