Results 1 to 10 of about 3,296 (190)

Secretory Phospholipases A₂ in Plants. [PDF]

Front Plant Sci, 2019
Secreted phospholipases (sPLA2s) in plants are a growing group of enzymes that catalyze the hydrolysis of sn-2 glycerophospholipids to lysophospholipids and free fatty acids. Until today, around only 20 sPLA2s were reported from plants.
Mariani ME, Fidelio GD.
europepmc   +8 more sources

Short Linear Motifs Characterizing Snake Venom and Mammalian Phospholipases A2 [PDF]

Toxins, 2021
Snake venom phospholipases A2 (PLA2s) have sequences and structures very similar to those of mammalian group I and II secretory PLA2s, but they possess many toxic properties, ranging from the inhibition of coagulation to the blockage of nerve ...
Caterina Peggion, Fiorella Tonello
exaly   +4 more sources

In Silico Evaluation of Quercetin Methylated Derivatives on the Interaction with Secretory Phospholipases A2 from Crotalus durissus terrificus and Bothrops jararacussu. [PDF]

Pharmaceuticals (Basel), 2023
Quercetin derivatives have already shown their anti-inflammatory potential, inhibiting essential enzymes involved in this process. Among diverse pro-inflammatory toxins from snake venoms, phospholipase A2 is one of the most abundant in some species, such
Belchor MN, Costa CRDC, Roggero A, Moraes LLF, Samelo R, Annunciato I, de Oliveira MA, Sousa SF, Toyama MH.   +8 more
europepmc   +2 more sources

Secreted Phospholipases A2 from Animal Venoms in Pain and Analgesia

Toxins, 2017
Animal venoms comprise a complex mixture of components that affect several biological systems. Based on the high selectivity for their molecular targets, these components are also a rich source of potential therapeutic agents.
Gisele Picolo, CARLOS A H Fernandes, Marcos R M Fontes   +2 more
exaly   +3 more sources

Differential expression of secretory phospholipases A2 in normal and malignant prostate cell lines: regulation by cytokines, cell signaling pathways, and epigenetic mechanisms. [PDF]

Neoplasia, 2008
Upregulation of group IIA phospholipase A2 (sPLA2-IIA) correlates with prostate tumor progression suggesting prooncogenic properties of this protein. Here, we report data on expression of three different sPLA2 isozymes (groups IIA, V, and X) in normal ...
Menschikowski M, Hagelgans A, Gussakovsky E, Kostka H, Paley EL, Siegert G.   +5 more
europepmc   +2 more sources

Distinct Roles of Myeloid- and Hepatocyte-PLA2G6 Deletion in Mice With Metabolic Dysfunction-Associated Steatotic Liver Disease. [PDF]

Liver Int
ABSTRACT Background and Aims Polymorphisms of group VIA calcium‐independent phospholipase A2 (iPLA2β or PLA2G6) are associated with Type‐2 diabetes, blood lipids and inflammation. Global deficiency in iPLA2β‐null mice elicited protection against hepatic steatosis but not hepatic inflammation after high‐fat diet (HFD) feeding.
Li G, Staffer S, Tuma-Kellner S, Merle U, Chamulitrat W.   +4 more
europepmc   +2 more sources

Contribution of individual phospholipase A₂ enzymes to the cleavage of oxidized phospholipids in human blood plasma. [PDF]

J Lipid Res
Phospholipids containing oxidized esterified PUFA residues (OxPLs) are increasingly recognized for multiple biological activities and causative involvement in disease pathogenesis.
Jokesch P, Oskolkova O, Fedorova M, Gesslbauer B, Bochkov V.   +4 more
europepmc   +2 more sources

Ustilago maydis Phosphatidic Acid and Phosphatidylserine-Targeting Secreted Lipase Lip3 Is Involved in Pathogenesis. [PDF]

Mol Plant Pathol
Ustilago maydis secreted lipase, Lip3 targets PA and PS and alkalinises the host apoplast, thus promoting virulence. Loss of Lip3 results in reduced apoplastic pH and decreased pathogenicity. ABSTRACT Lipases constitute important virulence factors. By targeting specific lipids involved in various cellular processes, lipases regulate growth, development,
Roy A, Mondal R, Ghosh A.
europepmc   +2 more sources

Molecular components of the FPR2/ALX pathway participate in astrocyte-neuron resolution responses to afford maneb-induced toxicity. [PDF]

Cell Mol Life Sci
Environmental toxicants such as maneb (MB), a dithiocarbamate pesticide, trigger progressive neuronal death, probably due to the imbalance in inflammation/resolution mechanisms, resulting in the onset of neurodegeneration.
Benzi Juncos ON, Alza NP, Cordero JL, Barrera NP, Salvador GA.   +4 more
europepmc   +2 more sources

Secretory Phospholipases A2 Are Secreted From Ciliated Cells and Increase Mucin and Eicosanoid Secretion From Goblet Cells [PDF]

Chest, 2015
Tsuyoshi Tanabe, Soichiro Kanoh, Bruce K Rubin   +2 more
exaly   +2 more sources