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Secretory Protein Trafficking: Genetic and Biochemical Analysis
Cell Biochemistry and Biophysics, 2004Acute insulin secretion from stimulated pancreatic beta-cells is derived from the intracellular pool of insulin secretory granules wherein insulin is packaged in a highly concentrated (and in some species, crystalline) state. Here we review experimental work, principally from our laboratory, on the question of biogenesis of mature secretory granules ...
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Core Proteins of the Secretory Machinery
2008Members of the Rab, SM- and SNARE-protein families play key roles in all intracellular membrane trafficking steps. While SM- and SNARE-proteins become directly involved in the fusion reaction at a late stage, Rabs and their effectors mediate upstream steps such as vesicle budding, delivery, tethering, and transport.
Lang, T., Jahn, R.
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Plasma levels of platelet secretory proteins
Critical Reviews in Oncology/Hematology, 1986Platelets contain three types of secretory organelles: the dense granules, the alpha granules, and the lysosomes. Most of the proteins secreted from platelets are stored in the alpha granules, whereas the dense granules contain substances such as adenine nucleotides, serotonin, Ca++, and inorganic pyrophosphate types as well as a heparatinase. Three of
Karen L. Kaplan +2 more
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Secretory Endometrium Synthesizes Placental Protein 14*
Endocrinology, 1986Saline extracts of human nonpregnant endometrium were found to contain placental protein 14 (PP14). The tissue PP14 content was highest in the late secretory phase (median, 7.7 mg/g protein; n = 14), whereas proliferative endometrium (n = 8) was either PP14 negative or showed a low PP14 content (median, 0.15 mg/g protein). By immunoperoxidase staining,
M, Julkunen +5 more
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Immunomodulatory action of mycobacterial secretory proteins
Microbes and Infection, 2004The recently discovered RD1 locus encodes proteins that are actively secreted by pathogenic mycobacteria, including Mycobacterium tuberculosis. Since they are missing in non-tuberculous mycobacteria, these proteins are promising not only as candidates for vaccination and diagnostic tests, but also in understanding mycobacterial evasion of protective ...
Vladimir, Trajkovic +2 more
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The perplexing PEXEL protein secretory pathway
Nature Microbiology, 2018Plasmodium parasites possess a unique PEXEL sorting pathway to deliver secretory proteins into the host cells in which they reside. A new study shows the existence of independent sorting/entry complexes to detect and deliver PEXEL proteins into the parasite endoplasmic reticulum.
Pool, Martin, Russo, Ilaria
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Protein processing within the secretory pathway
Current Opinion in Biotechnology, 1992Endoproteolytic cleavage of hormone and neuropeptide precursors, as well as many complex proteins, such as coagulation factors and viral glycoproteins, is a key process in the generation of bioactive polypeptides. These cleavages typically occur at the dibasic amino acid residues Lys-Arg or Arg-Arg.
A, Rehemtulla, R J, Kaufman
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Journal of Mass Spectrometry, 2008
AbstractAnalysis of secretory proteins is an important area in proteomic research. We propose that a good secretory protein sample should be enriched with known secretory proteins, and a secretory protein should be enriched in the secretory protein sample compared with its corresponding soluble cell lysate.
Yong, Chen +6 more
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AbstractAnalysis of secretory proteins is an important area in proteomic research. We propose that a good secretory protein sample should be enriched with known secretory proteins, and a secretory protein should be enriched in the secretory protein sample compared with its corresponding soluble cell lysate.
Yong, Chen +6 more
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Secretory granule formation and synthesis pathway of secretory proteins in parotid gland cells
European Journal of Morphology, 1996The cytochemical technique for endogenous peroxidase and an immunocytochemical method with protein A-gold were used to investigate the formation of the secretory granule substructure in acinar cells of the gerbil parotid glands in normal conditions and after treatment with the ionophore monensin.
K, Takano +3 more
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Differential reaction of secretory and non‐secretory proteins in hormone‐treated dunning tumor
The Prostate, 1989AbstractTumor cells from of the Dunning R‐3327 PAP tumor were grown in vivo in the flank region of male Copenhagen rats for 4 months. Untreated control animals, castrated animals, and untreated or castrated animals supplemented with testosterone and estramustine (alone or in combination) bearing tumors were used for immunocytochemical studies of the ...
G, Aumüller, B, Hartley-Asp, J, Seitz
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