SEC24A deficiency lowers plasma cholesterol through reduced PCSK9 secretion. [PDF]
, 2013 The secretory pathway of eukaryotic cells packages cargo proteins into COPII-coated vesicles for transport from the endoplasmic reticulum (ER) to the Golgi.
Adams, Elizabeth +17 more
core +1 more source
Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]
, 2013 Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Crawford, Sue E. +4 more
core +2 more sources
Functional identification of a Streptomyces lividans FKBP-like protein involved in the folding of overproduced secreted proteins [PDF]
Open Biology, 2019 Some bacterial peptidyl-prolyl cis/trans isomerases (PPIases) are involved in secretory protein folding after the translocation step. Streptomyces lividans has been used as a host for engineering extracellular overproduction of homologous and ...
R. L. Vicente +5 more
doaj +1 more source
An ancestral secretory apparatus in the protozoan parasite Giardia intestinalis [PDF]
, 2003 The protozoan parasite Giardia intestinalis belongs to one of the earliest diverged eukaryotic lineages. This is also reflected in a simple intracellular organization, as Giardia lacks common subcellular compartments such as mitochondria, peroxisomes ...
Hehl, Adrian B. +7 more
core +1 more source
A single polar residue and distinct membrane topologies impact the function of the infectious bronchitis coronavirus E protein. [PDF]
PLoS Pathogens, 2012 The coronavirus E protein is a small membrane protein with a single predicted hydrophobic domain (HD), and has a poorly defined role in infection. The E protein is thought to promote virion assembly, which occurs in the Golgi region of infected cells. It
Travis R Ruch, Carolyn E Machamer
doaj +1 more source
Cells, 2020 The cellular mechanisms that ensure the selectivity and fidelity of secretory cargo protein transport from the endoplasmic reticulum (ER) to the Golgi are still not well understood.
Sergio Lopez +8 more
doaj +1 more source
Advanced Science, 2023 Tissue‐infiltrating neutrophils (TINs) secrete various signaling molecules to establish paracrine communication within the inflammatory milieu. It is imperative to identify molecular mediators that control this secretory phenotype of TINs.
Jia Song +17 more
doaj +1 more source
Russell-like bodies in plant seeds share common features with prolamin bodies and occur upon recombinant protein production [PDF]
, 2019 Although many recombinant proteins have been produced in seeds at high yields without adverse effects on the plant, endoplasmic reticulum (ER) stress and aberrant localization of endogenous or recombinant proteins have also been reported.
Arcalis, Elsa +13 more
core +2 more sources
CapsNet-SSP: multilane capsule network for predicting human saliva-secretory proteins
BMC Bioinformatics, 2020 Background Compared with disease biomarkers in blood and urine, biomarkers in saliva have distinct advantages in clinical tests, as they can be conveniently examined through noninvasive sample collection.
Wei Du +5 more
doaj +1 more source
European Journal of Histochemistry, 2021 In the present study, the expression of secretory components and vesicular transport proteins in the canine lacrimal gland was examined and morphometric analysis was performed.
Tadashi Yasui +4 more
doaj +1 more source