Results 51 to 60 of about 490,442 (360)

Secretory protein targeting in a pituitary cell line: differential transport of foreign secretory proteins to distinct secretory pathways. [PDF]

The Journal of cell biology, 1985
The mouse pituitary cell line, AtT-20, packages the adrenocorticotropic hormone (ACTH) in secretory vesicles and releases it when the cell is stimulated with secretagogues. These cells have the capacity, after transfection with the appropriate DNA, to package heterologous peptide hormones into the regulated secretory vesicles (Moore, H. P. H., M.
H P, Moore, R B, Kelly
openaire   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Ca2+ uptake to purified secretory vesicles from bovine neurohypophyses [PDF]

, 1982
Purified secretory vesicles isolated from bovine neurohypophyses were found to take up Ca2+ when incubated at 30°C in media containing 10−7 to 10−4 M free Ca2+. At 10−4 free Ca2+ 19 nmol/mg protein were taken up within 30 min.
Baker, Banks, Barer, Blaustein, Borle, Bowman, Böhlen, Conigrave, Crompton, Dicker, Ginsburg, Gratzl, Gratzl, Heidemarie I. Krieger-Brauer, Krieger-Brauer, Krieger-Brauer, Lehninger, Lehninger, Manfred Gratzl, Morris, Niels A. Thorn, Normann, Olsen, Pressman, Rasmussen, Robinson, Russell, Saermark, Thorn, Thorn, Torben Særmark, Torp-Pedersen, Torp-Pedersen, Vilhardt, Vilhardt, Weiss   +35 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Imbalance of heterologous protein folding and disulfide bond formation rates yields runaway oxidative stress

BMC Biology, 2012
Background The protein secretory pathway must process a wide assortment of native proteins for eukaryotic cells to function. As well, recombinant protein secretion is used extensively to produce many biologics and industrial enzymes. Therefore, secretory
Tyo Keith EJ, Liu Zihe, Petranovic Dina, Nielsen Jens   +3 more
doaj   +1 more source

Effects of Monovalent and Divalent Cations on Ca2+ Fluxes Across Chromaffin Secretory Membrane Vesicles [PDF]

, 1983
: Bovine chromaffin secretory vesicle ghosts loaded with Na+ were found to take up Ca2+ when incubated in K+ media or in sucrose media containing micromolar concentrations of free Ca2+. Li+- or choline+loaded ghosts did not take up Ca2+.
Baker P. F., Borle A. B., Carafoli E., Flodgaard H., Goldstone T. P., Heidemarie I. Krieger-Brauer, Kostron H., Lowry O. H., Manfred Gratzl, Phillips J. H., Reed K. C., Saermark T., Sandeaux R., Sillen L. G.   +13 more
core   +1 more source

Phosphorylation of parathyroid secretory protein. [PDF]

Proceedings of the National Academy of Sciences, 1983
The phosphorylation of proteins released into the medium of bovine parathyroid gland slices or isolated cells incubated with 32Pi has been investigated. The primary protein phosphorylated had a Mr of 68,000 and coeluted with newly synthesized parathyroid secretory protein (PSP) on Bio-Gel chromatography and on polyacrylamide gel electrophoresis ...
G, Bhargava, J, Russell, L M, Sherwood
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress

Neural Regeneration Research
Neuroserpin, a secreted protein that belongs to the serpin superfamily of serine protease inhibitors, is highly expressed in the central nervous system and plays multiple roles in brain development and pathology.
Yumei Liao, Qinghua Zhang, Qiaoyun Shi, Peng Liu, Peiyun Zhong, Lingling Guo, Zijian Huang, Yinghui Peng, Wei Liu, Shiqing Zhang, István Adorján, Yumi Fukuzaki, Eri Kawashita, Xiao-Qi Zhang, Nan Ma, Xiaoshen Zhang, Zoltán Molnár, Lei Shi   +17 more
doaj   +1 more source

Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells

Frontiers in Endocrinology, 2019
Glucagon is stored within the secretory granules of pancreatic alpha cells until stimuli trigger its release. The alpha cell secretory responses to the stimuli vary widely, possibly due to differences in experimental models or microenvironmental ...
Farzad Asadi, Savita Dhanvantari, Savita Dhanvantari, Savita Dhanvantari   +3 more
doaj   +1 more source