Results 61 to 70 of about 136,194 (301)

On Einstein Manifolds of Positive Sectional Curvature

open access: yesAnnals of Global Analysis and Geometry, 1999
Let (M,g) be a compact oriented Einstein 4-manifold. If M has positive intersection form and g has non-negative sectional curvature, we show that, up to rescaling and isometry, (M,g) is CP2, equipped with its standard Fubini-Study metric.
Gursky, Matthew J., LeBrun, Claude
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

The Cross Curvature Flow of 3-manifolds with Negative Sectional Curvature

open access: yes, 2003
We introduce a geometric evolution equation for 3-manifolds with sectional curvature of one sign which is in some sense dual to the Ricci flow. On a closed 3-manifold with negative sectional curvature, we establish short time existence and a pair of monotonicity formulas for solutions to the flow. One of these formulas shows that, provided the solution
Chow, Bennett, Hamilton, Richard S.
openaire   +3 more sources

An estimate of sectional curvatures of hypersurfaces with positive Ricci curvatures [PDF]

open access: yesProceedings of the Edinburgh Mathematical Society, 1995
Let M be a hypersurface in Euclidean space and let the Ricci curvature of M be bounded below by some nonnegative constant. In this paper, we estimate the sectional curvature of M in terms of the lower bound of Ricci curvature and the upper bound of mean curvature.
Kim, Ju Seon, Kim, Sang Og
openaire   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Some Applications of Casorati Curvature for Statistical Submanifolds of Sasakian Statistical Manifolds and Locally Homogeneous, Quasi-Umbilical Hypersurfaces

open access: yesپژوهش‌های ریاضی, 2021
In this paper, in the first part, the affine geometry is assumed as the main framework. Then we have a spacious explanation of necessary introduction in rather different subjects.
Azam Etemad Dehkordy
doaj  

A New Proof of a Conjecture on Nonpositive Ricci Curved Compact Kähler–Einstein Surfaces

open access: yesMathematics, 2018
In an earlier paper, we gave a proof of the conjecture of the pinching of the bisectional curvature mentioned in those two papers of Hong et al. of 1988 and 2011. Moreover, we proved that any compact Kähler–Einstein surface M is a quotient of the complex
Zhuang-Dan Daniel Guan
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

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