Results 61 to 70 of about 129,831 (277)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Almost Kähler manifolds whose antiholomorphic sectional curvature is pointwise constant [PDF]

Rendiconti di Matematica e delle Sue Applicazioni, 1998
We prove that an almost Kähler manifold (M, g, J) with dim M ≥ 8 and pointwise constant antiholomorphic sectional curvature is a complex space-form.
M. Falcitelli, A. Farinola, O.T. Kassabov   +2 more
doaj  

A basic inequality for submanifolds in a cosymplectic space form

International Journal of Mathematics and Mathematical Sciences, 2003
For submanifolds tangent to the structure vector field in cosymplectic space forms, we establish a basic inequality between the main intrinsic invariants of the submanifold, namely, its sectional curvature and scalar curvature on one side; and its main ...
Jeong-Sik Kim, Jaedong Choi
doaj   +1 more source

Mixed sectional-Ricci curvature obstructions on tori

, 2017
We establish new obstruction results to the existence of Riemannian metrics on tori satisfying mixed bounds on both their sectional and Ricci curvatures.
Kloeckner, Benoît, Sabourau, Stéphane
core  

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

A Kähler Einstein structure on the tangent bundle of a space form

International Journal of Mathematics and Mathematical Sciences, 2001
We obtain a Kähler Einstein structure on the tangent bundle of a Riemannian manifold of constant negative curvature. Moreover, the holomorphic sectional curvature of this Kähler Einstein structure is constant.
Vasile Oproiu
doaj   +1 more source

Almost Kenmotsu $f$-manifolds

Karpatsʹkì Matematičnì Publìkacìï, 2015
In this paper, we consider a generalization of almost Kenmotsu f-manifolds. We get basic Riemannian curvature, sectional curvatures and scalar curvature properties such type manifolds. Finally, we give two examples to clarify some our results.
Y.S. Balkan, N. Aktan
doaj   +1 more source

Casorati Inequalities for Statistical Submanifolds in Kenmotsu Statistical Manifolds of Constant ϕ-Sectional Curvature with Semi-Symmetric Metric Connection. [PDF]

Entropy (Basel), 2022
Decu S, Vîlcu GE.
europepmc   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source