Results 101 to 110 of about 1,445,751 (341)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
'Don't take it home with you': Views of secure care staff on debrief after restraint
Scottish Journal of Residential Child CareThere is a dearth of research into debrief after restraint in secure and residential childcare. This research sought the views of care workers on debrief practice across three secure centres in Scotland, using a mixed methods qualitative approach. It was
Abbi Jackson
doaj +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Journal of Medical Internet Research, 2013 BackgroundDespite significant consumer interest and anticipated benefits, overall adoption of personal health records (PHRs) remains relatively low. Understanding the consumer perspective is necessary, but insufficient by itself.
Nazi, Kim M
doaj +1 more source
The Role of Secure Marriage, Cognitive Flexibility, Hexaco Personality Dimensions on Predicting Covid-19 Self-Care Behavior in Married Women [PDF]
, 2021 پرستو گمرکی +1 more
openalex +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Baby steps or giant strides? [PDF]
In its 2014 review of the child care sector, the Productivity Commission revealed that parents of one in six children were struggling to access child care services in their area, with just over one half of parents indicating that a failure to secure ...
Deborah Brennan, Elizabeth Adamson
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Exploration of adverse patterns of placement of young people in secure care: The unwanted child? [PDF]
Crim Behav Ment Health, 2022 Smith JG, Bartlett A, Hales H.
europepmc +1 more source
Securing Health for Children in the Care of the State [PDF]
, 2002 Mary Mather
openalex +1 more source