Results 81 to 90 of about 399,623 (388)

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Problems of Sedation and Anæsthesia, and the Management of the Disorientated Surgical Patient [PDF]

, 1963
A Edridge
  +5 more sources

Single cis‐elements in brassinosteroid‐induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA‐binding domain

FEBS Letters, EarlyView.
Phytohormone brassinosteroid‐induced gene regulation by the transcription factor BIL1/BZR1 involves redox‐dependent DNA‐binding alternation and interaction with the transcription factor PIF4. The reduced BIL1/BZR1 dimer binds preferred cis‐elements, while oxidation alters its oligomerization state and disrupts DNA‐binding ability.
Shohei Nosaki, Masae Ohtsuka, Takeshi Nakano, Masaru Tanokura, Takuya Miyakawa   +4 more
wiley   +1 more source

Procedural Sedation and Analgesia in Children: Perspectives from Paediatric Emergency Physicians

Proceedings of Singapore Healthcare, 2010
Procedural sedation and analgesia in children is now widely practised in many emergency departments internationally. In this article, we address the general principles, indications, guidelines, medications, adverse events and future research in ...
Lai Peng Tham MBBS, MMed (Paediatrics), Khai Pin Lee M.Med (Paediatrics) MRCPCH   +1 more
doaj   +1 more source

PERBANDINGAN PENGUKURAN STATUS SEDASI RICHMOND AGITATION SEDATION SCALE (RASS) DAN RAMSAY SEDATION SCALE (RSS) PADA PASIEN GAGAL NAFAS TERHADAP LAMA WEANING VENTILATOR DI GICU RSUP Dr.HASAN SADIKIN BANDUNG

Jurnal Riset Kesehatan, 2017
Sedation is an important factor to improve patient comfort. Over sedation may lead to a longer ventilator time. To prevent over sedation need an instrument can measure accurately the status of sedation. This study aimed to analyze the differences between 
Hellena Deli, Muhammad Zafrullah Arifin, Sari Fatimah   +2 more
doaj   +1 more source

Comparison of Triple Combination Oral Sedation Regimens for Pediatric Dental Treatment [PDF]

, 2019
Purpose: Compare the efficacy of two benzodiazepines (diazepam or midazolam) in combination with meperidine and hydroxyzine for pediatric dental sedation.
Henderson, Brett H
core   +1 more source

Alcohol-Induced Histone Acetylation Reveals a Gene Network Involved in Alcohol Tolerance [PDF]

, 2013
Alfredo Ghezzi, Harish R. Krishnan, Linda Lew, Francisco J. Prado III, Darryl S. Ong, Nigel S. Atkinson, Section of Neurobiology and Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, Texas, United States of ...
Atkinson, Nigel S., Ghezzi, Alfredo, Krishnan, Harish R., Lew, Linda, Ong, Darryl S., Prado III, Francisco J.   +5 more
core   +3 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Current sedation practices for non-invasive procedures in tertiary maternity and children’s hospitals in China: a 5-year update

BMJ Paediatrics Open
Background Sedation techniques can ease anxiety during medical procedures for children. Our previous report on Chinese sedation practices for non-invasive procedures in 2018 is outdated due to the rapid development of sedation services.
Lu Wang, Bo Li, Ruidong Zhang, Yanhui Huang, Mazhong Zhang, Jijian Zheng   +5 more
doaj   +1 more source

Sedation and Paralysis [PDF]

Respiratory Care, 2013
Sedation is used almost universally in the care of critically ill patients, especially in those who require mechanical ventilatory support or other life-saving invasive procedures. This review will focus on the sedation strategies for critically ill patients and the pharmacology of commonly used sedative agents.
Edward A. Bittner, Jessica Hines, Annop Piriyapatsom, Ulrich Schmidt   +3 more
openaire   +3 more sources