Results 91 to 100 of about 1,433,306 (343)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A review of reservoir carbon Cycling: Key Processes, influencing factors and research methods

Ecological Indicators
Based on the focus on the role of reservoirs as carbon sources and sinks, this article explores their impact on the global carbon cycle. Reservoirs, which are “artificial lakes” created by human activities in rivers, are reviewed in terms of the key ...
Chunhui Li, Yihan Wang, Yujun Yi, Xuan Wang, Celso Augusto Guimarães Santos, Qiang Liu   +5 more
doaj   +1 more source

Numerical Modeling of Debris Flows Induced by Dam-Break Using the Smoothed Particle Hydrodynamics (SPH) Method

Applied Sciences, 2020
Dam-break flows may change into debris flows if certain conditions are satisfied, such as abundant loose material and steep slope. These debris flows are typically characterized by high density and can generate strong impact forces. Due to the complexity
Anping Shu, Shu Wang, Matteo Rubinato, Mengyao Wang, Jiping Qin, Fuyang Zhu   +5 more
doaj   +1 more source

Topographic Development History of the Alaska Range [PDF]

, 2014
The overall goal of this project is to use variations in sediment source through time as a proxy for deciphering the uplift history of the Alaska Range (Fig. 1).
Davis, Kailyn N.
core  

Enrichment of organic carbon in sediment transport by interrill and rill erosion processes [PDF]

, 2008
Erosion and loss of organic carbon (OC) result in degradation of the soil surface. Rill and interrill erosion processes on a silt loam soil were examined in laboratory rainfall and flume experiments.
Cornelis, Wim, Gabriëls, Donald, Hofman, Georges, Schiettecatte, Wouter   +3 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Bedform dimensions under supply limited conditions [PDF]

, 2008
The volume of mobile sediment on the river bed is the primary control on the dimensions of the bed forms that develop. If an unlimited supply of sediment is available the bed form dimensions which develop are determined by the water depth, the flow ...
Ribberink, J.S., Tuijnder, A.P.
core   +1 more source

Faunal response to benthic and hyporheic sedimentation varies with direction of vertical hydrological exchange [PDF]

, 2014
1. Sedimentation and clogging of benthic and hyporheic zone substrates is increasingly being recognised as one of the greatest threats to the ecological integrity of riverine ecosystems globally. This ex-situ study examined the influence of sedimentation
Bo, Boano, Boulton, Boulton, Boulton, Brunke, Brunke, Bruno, Collins, Davy-Bowker, Descloux, Descloux, Descloux, Dole-Oliver, Dunbar, Evans, Extence, Fowler, Franken, Gayraud, Gledhill, Greig, Huettel, IBM Corp, Izagirre, Jones, Jones, Joyce, Kemp, Krause, Larned, Larson, MacNeil, MacNeil, Malcolm, Maridet, Navel, Olsen, Pacioglu, Packman, Packman, Pepin, Plenet, Ren, Richards, Robertson, Ryan, Sarriquet, Simpson, Studinski, Stump, Taylor, Walters, Wang, Weigelhofer, Wood, Wood, Xu, Zweig   +58 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A new methodology for the quantitative visualization of coherent flow structures in alluvial channels using multibeam echo-sounding (MBES) [PDF]

, 2010
In order to investigate the interactions between turbulence and suspended sediment transport in natural aqueous environments, we ideally require a technique that allows simultaneous measurement of fluid velocity and sediment concentration for the whole ...
Best, J L, Best, Jim, Czuba, Jonathan, Malzone, Chris, Oberg, Kevin, Parsons, Daniel, Simmons, Stephen, Simmons, Steve   +7 more
core   +2 more sources