Results 91 to 100 of about 1,803,074 (391)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Sediment structure and physicochemical changes following tidal inundation at a large open coast managed realignment site [PDF]

, 2018
Managed realignment (MR) schemes are being implemented to compensate for the loss of intertidal saltmarsh habitats by breaching flood defences and inundating the formerly defended coastal hinterland.
Andrew B. Cundy, Auxtero, Bergen, Berrow, Beven, Bone, Burton, Cnudde, Cochran, Cope, Costanza, Crooks, Crooks, Croudace, Cundy, Cundy, Cundy, Cundy, Dale, Dale, Dale, David J. Nash, Davy, Doherty, Doody, Elliott, Environment Agency, Erfanzadeh, Esteves, European Parliament and the Council of the European Commission, Foster, French, Hazelden, Heidi M. Burgess, Howe, Hvorslev, Ian W. Croudace, Johnston, Jonathan Dale, Kate L. Spencer, Ketcham, Koretsky, Krawiec, Luther, Marani, Mazik, Miller, Moller, Mossman, Odgaard, Pearce, Polder, Reid, Rowell, Rupprecht, Shennan, Shennan, Simon J. Carr, Spencer, Spencer, Spencer, Tempest, Violante, Vogel, Vranken, Watts, Wilson, Wolanski, Zwolsman   +68 more
core   +3 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Factors affecting colour and cloud stability in a wildberry herbal drink : a thesis presented in partial fulfilment of the requirements for the degree of M. Tech. in Food Science at Massey University, Albany, New Zealand [PDF]

, 2001
An investigation was undertaken into the stability of the natural colour, from anthocyanins, and cloud in a Wildberry Herbal fruit drink. The fruit drinks consisted of cloudy apple and berry fruit juice with natural herb extracts and flavours.
Evans, John R
core  

Anomalous luminescence of subglacial sediment at Haut glacier d'Arolla, Switzerland - a consequence of resetting at the glacier bed? [PDF]

, 2010
<p>Luminescence has the potential to elucidate glacial geomorphic processes because primary glacial sediment sources and transport pathways are associated with contrasting degrees of exposure to light.
Aitken, Aitken, Alley, Alley, Armitage, Bailey, Bateman, Bateman, Berger, Blair, Blake, Boulton, Burbidge, Copland, Dreimanis, Fischer, Fuchs, Fukuchi, Galbraith, Gemmell, Gemmell, Goodsell, Grenfell, Grum, Gurnell, Harbor, Hubbard, Krbetschek, Lee, Lian, Liritzis, Lukas, Murray, Nienow, Pegau, Rhodes, Rhodes, Rink, Sanderson, Sanderson, Sanderson, Sharp, Singhvi, Stone, Swift, Swift, Thomas, Toyoda, Tranter, Wallinga, Wallinga, Wintle, Wintle, Zöller   +53 more
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Hydrological changes in the Upper Yellow River under the impact of upstream cascade reservoirs over the past 70 years

Journal of Hydrology: Regional Studies
Study region: The Upper Yellow River Basin (UYRB), China. Study focus: In this study, a variety of mathematical statistical methods, the Indicators of Hydrologic Alteration—Range of Variability (IHA-RVA) method, and the newly proposed Flow Surplus ...
Jing Hu, Xiong Zhou, Yujun Yi, Chunhui Li, Xuan Wang, Qiang Liu, Jiansu Mao   +6 more
doaj   +1 more source

Numerical Modeling of Debris Flows Induced by Dam-Break Using the Smoothed Particle Hydrodynamics (SPH) Method

Applied Sciences, 2020
Dam-break flows may change into debris flows if certain conditions are satisfied, such as abundant loose material and steep slope. These debris flows are typically characterized by high density and can generate strong impact forces. Due to the complexity
Anping Shu, Shu Wang, Matteo Rubinato, Mengyao Wang, Jiping Qin, Fuyang Zhu   +5 more
doaj   +1 more source

Topographic Development History of the Alaska Range [PDF]

, 2013
he overall goal of this project is to use variations in sediment source through time as a proxy for deciphering the uplift history of the Alaska Range (Fig. 1).
Davis, Kailyn
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source