Results 91 to 100 of about 1,170,038 (344)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Hydrological changes in the Upper Yellow River under the impact of upstream cascade reservoirs over the past 70 years

Journal of Hydrology: Regional Studies
Study region: The Upper Yellow River Basin (UYRB), China. Study focus: In this study, a variety of mathematical statistical methods, the Indicators of Hydrologic Alteration—Range of Variability (IHA-RVA) method, and the newly proposed Flow Surplus ...
Jing Hu, Xiong Zhou, Yujun Yi, Chunhui Li, Xuan Wang, Qiang Liu, Jiansu Mao   +6 more
doaj   +1 more source

Numerical Modeling of Debris Flows Induced by Dam-Break Using the Smoothed Particle Hydrodynamics (SPH) Method

Applied Sciences, 2020
Dam-break flows may change into debris flows if certain conditions are satisfied, such as abundant loose material and steep slope. These debris flows are typically characterized by high density and can generate strong impact forces. Due to the complexity
Anping Shu, Shu Wang, Matteo Rubinato, Mengyao Wang, Jiping Qin, Fuyang Zhu   +5 more
doaj   +1 more source

Hydrological factors influencing sediment concentration fluctuations in small drainage basins [PDF]

, 1971
Although sediment concentrations measured in two contrasting streams in East Yorkshire fluctuate in response to similar hydrological factors, the effectiveness of these factors reflects the environmental characteristics of the drainage basins ...
Imeson, A.C.
core   +1 more source

High-resolution palynological analysis in Lake Sapanca as a tool to detect recent earthquakes on the North Anatolian Fault [PDF]

, 2009
High-resolution palynological analysis of a 38-cm-long core collected from Lake Sapanca, northwest Turkey, reveals large earthquakes that occurred during the second half of the 20th century along the North Anatolian Fault Zone. Four events have disturbed
Boyraz, S, Gürbüz, A, Leroy, SAG
core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Sediment

, 2018
Sediment is a series of abstract narrations which combine the generative visuals of Lali Barrière with the static music of Ferran Fages, with a clearly minimalist approach. The visuals use a single graphic element: the line, horizontal or vertical.
Barrière Figueroa, Eulalia, Fages, Ferran   +1 more
openaire   +1 more source

Medium-term performance and maintenance of SUDS:a case-study of Hopwood Park Motorway Service Area, UK [PDF]

, 2008
One of the main barriers to implementing SUDS is concern about performance and maintenance costs since there are few well-documented case-studies. This paper summarizes studies conducted between 2000 and 2008 of the performance and maintenance of four ...
Bray, R., Briers, M., Fogg, P., Heal, K. V., Jefferies, Christopher, Napier, F., Willingale, S. A. J.   +6 more
core   +5 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Use of axial tomography to follow temporal changes of benthic communities in an unstable sedimentary environment (Baie des Ha! Ha!, Saguenay Fjord) [PDF]

, 2003
In the upper layer of the sediment column, organic matter recycling is greatly influenced by bioturbation. However, there are many physical changes in the nature of the sediment that may disturb benthic communities and create a biogeochemical imbalance ...
Aller, Aller, Aller, Aller, Aller, Aller, Berger, Bernard Long, Boespflug, Boespflug, Bray, Canfield, Clarke, Coleman, Crémer, de Montety, Deflandre, Desrosiers, du Berger, Duliu, Emilien Pelletier, Emma Michaud, Franck Gilbert, François, Gage, Gaston Desrosiers, Georges Stora, Gilbert, Gérino, Gérino, Hounsfield, Hulthe, Jacques Locat, Jean-François Crémer, Jones, Kantzas, Kenter, Krantzberg, Kristensen, Kuehl, Lapointe, Laure de Montety, Ligier, Locat, Maurice, Michaud, Mucci, Nerhing, Orsi, Pearson, Pearson, Pelletier, Pelletier, Prena, Rhoads, Rhoads, Rhoads, Rhoads, Rhoads, Risk, Schafer, Sorensen, Stora, Thistle, Tita, Urgelès, Wellington, Yeo, Yu, Zajac, Zar   +70 more
core   +4 more sources