Results 81 to 90 of about 3,063,115 (364)

Modelling subglacial fluvial sediment transport with a graph-based model, Graphical Subglacial Sediment Transport (GraphSSeT) [PDF]

The Cryosphere
A quantitative understanding of how sediment discharge from subglacial fluvial systems varies in response to glaciohydrological conditions is essential for understanding marine systems around Greenland and Antarctica and for interpreting sedimentary ...
A. R. A. Aitken, A. R. A. Aitken, I. Delaney, G. Pirot, G. Pirot, M. A. Werder, M. A. Werder   +6 more
doaj   +1 more source

Bioturbation experiments in the Venice Lagoon [PDF]

, 2003
Short experiments (14–21 days) were carried out during autumn 1998 and spring 1999 at one selected site of the Venice Lagoon to measure bioturbation activities and mixing rates, as well as to obtain quantitative information on benthos functionality ...
Bellucci, Luca Giorgio, Frignani, Mauro, Gérino, Magali, Mugnai, Cristian, Sauvage, Sabine   +4 more
core   +6 more sources

Onset of sediment transport is a continuous transition driven by fluid shear and granular creep

Nature Communications, 2015
Fluid-sheared granular transport sculpts landscapes and undermines infrastructure, yet predicting the onset of sediment transport remains notoriously unreliable.
M. Houssais, C. Ortiz, D. Durian, D. Jerolmack   +3 more
semanticscholar   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Fine sediment transport into the hyper-turbid lower Ems River: the role of channel deepening and sediment-induced drag reduction

Deutsche Hydrographische Zeitschrift, 2015
Deepening of estuarine tidal channels often leads to tidal amplification and increasing fine sediment import. Increasing fine sediment import, in turn, may lower the hydraulic drag (due to a smoother muddy bed and/or sediment-induced damping of ...
D. S. Maren, J. Winterwerp, J. Vroom
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Construction of a monthly dynamic sediment delivery ratio model at the hillslope scale: a case study from a hilly loess region

Frontiers in Environmental Science
Introduction: Soil loss is a worldwide environmental problem, and sediment transport is one of its important components. In recent years, a hillslope sediment delivery ratio (SDR) model based on an index of connectivity has been widely used to describe ...
Zan Xu, Shanghong Zhang, Xujian Hu, Yang Zhou   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Study on the motion characteristics of bedload sediment particles under different sediment transport intensities

River
Bedload studies at the particle scale may help grasp the essence of the problem. Existing studies suffer from short filming durations, limited data volume, and a narrow range of sediment transport intensity variations.
Chunjing Liu, Lingfeng Zhang, Yu Zhang, Xiaopeng Jiang, Fei Liu, Leilei Gu, Jing Lu   +6 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source