Results 81 to 90 of about 201,517 (307)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Surface Erosion and Sedimentation Associated with Forest Land Use in Interior Alaska [PDF]

open access: yes, 1979
Completion reportThe magnitude of sheet-rill erosion associated with various landscape manipulations is presented. The Universal Soil Loss Equation's usefulness for predicting annual sheet-rill erosion within interior Alaska is confirmed ...
Aldrich, James W., Johnson, Ronald A.
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Hydrology, river regimes and sediment yield [PDF]

open access: yes, 2009
In comparison to the rest of Europe, Africa, and Asia, most rivers arising and flowing within the Mediterranean watershed typically drain small catchments with mountainous headwaters. The hydrology of Mediterranean catchments is strongly influenced by the seasonal distribution of precipitation, catchment geology, vegetation type and extent, and the ...
John Thornes, Jamie Woodward
openaire   +3 more sources

Changes in Different Classes of Precipitation and the Impacts on Sediment Yield in the Hekouzhen-Longmen Region of the Yellow River Basin, China

open access: yesAdvances in Meteorology, 2018
The sediment yield of the Yellow River Basin has obviously decreased since the 1980s, and the impacts of precipitation on sediment yield changes have become increasingly important with the global climate change.
Suzhen Dang   +4 more
doaj   +1 more source

Impact of urbanization on the sediment yield in tropical watershed using temporal land-use changes and a GIS-based model

open access: yesJournal of Water and Land Development, 2017
Abundant rainfall areas promote sediment yield at both sub-watershed and watershed scale due to soil erosion and increase siltation of river channel, but it can be curtailed through planned urbanization.
Bello Al-Amin D.   +2 more
doaj   +1 more source

Estimation of magnitudes of debris flows in selected torrential watersheds in Slovenia [PDF]

open access: yes, 2006
In this paper the application of different methods for estimation of magnitudes of rainfall-induced debris flows in 18 torrents in the Upper Sava River valley, NW Slovenia, and in 2 torrents in Pohorje, N Slovenia is described. Additional verification of
Mikoš, Matjaž, Sodnik, Jošt
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Gravel galore: Impacts of clear-cut logging on salmon and their habitats [PDF]

open access: yes, 2002
Timber harvest may have both direct and indirect effects on salmon, and with a few exceptions those effects result in lowered survival of salmon in their stream habitats compared with unlogged forest (Hicks et al. 1991b).
Hicks, Brendan J.
core   +1 more source

Beyond peak reservoir storage? A global estimate of declining water storage capacity in large reservoirs [PDF]

open access: yes, 2013
Water storage is an important way to cope with temporal variation in water supply and demand. The storage capacity and the lifetime of water storage reservoirs can be significantly reduced by the inflow of sediments.
Bierkens, Marc F. P.   +3 more
core   +2 more sources

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