Results 101 to 110 of about 636,102 (287)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Rapid Water Quality Mapping from Imaging Spectroscopy with a Superpixel Approach to Bio-Optical Inversion

Remote Sensing
High-resolution water quality maps derived from imaging spectroscopy provide valuable insights for environmental monitoring and management, but the processing of all pixels of large datasets is extremely computationally intensive and limits the speed of ...
Nicholas R. Vaughn, Marcel König, Kelly L. Hondula, Dominica E. Harrison, Gregory P. Asner   +4 more
doaj   +1 more source

Increased high-sensitivity C-reactive protein, erythrocyte sedimentation rate and lactic acid in stroke patients with internal carotid artery occlusion [PDF]

, 2015
Dan Xie, Di Hu, Qin Zhang, Yufang Sun, Jimei Li, Yongbo Zhang   +5 more
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Observing dust settling and coagulation in circumstellar discs: Selected constraints from high resolution imaging

, 2010
Circumstellar discs are expected to be the nursery of planets. Grain growth within such discs is the first step in the planet formation process in the core-accretion gas-capture scenario.
Beckwith, Bjorkman, Blum, Boss, Brauer, Brown, Cuzzi, Draine, Draine, Duchêne, Dullemond, Dullemond, D’Alessio, Garaud, Guilloteau, Gullbring, Güttler, J. Sauter, Kamp, Kemper, Kessler-Silacci, Kim, Lada, Langkowski, Lucy, Mathis, McCabe, Meeus, Mie, Neuhäuser, Ormel, Ossenkopf, Pinte, Przygodda, Robitaille, S. Wolf, Sauter, Schegerer, Schegerer, Shakura, Sicilia-Aguilar, Sicilia-Aguilar, Simon, Stapelfeldt, Stapelfeldt, Thamm, Weidenschilling, Weidling, Weingartner, Wilking, Witt, Wolf, Wolf, Wolf, Wood   +54 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Adsorption-Deposition Behavior of Typical Minerals on Antimony in Soil

Yankuang ceshi
Human activities such as mineral mining and coal combustion cause a large amount of antimony to enter into environmental soil. Exploring the adsorption deposition behavior of antimony on typical soil minerals is important for predicting the environmental
Guibin GUO, Xiaoya YUAN, Lijin HUANG, Qin SHUAI, Shenghong HU, Lei OUYANG   +5 more
doaj   +1 more source

Diffusion and Sedimentation Interaction Parameters for Measuring the Second Virial Coefficient and Their Utility as Predictors of Protein Aggregation [PDF]

, 2010
Atul Saluja, R. Matthew Fesinmeyer, Sabine Hogan, David N. Brems, Yatin R. Gokarn   +4 more
openalex   +1 more source