Results 81 to 90 of about 636,102 (287)

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

Slow sedimentation and deformability of charged lipid vesicles [PDF]

open access: yes, 2013
The study of vesicles in suspension is important to understand the complicated dynamics exhibited by cells in vivo and in vitro. We developed a computer simulation based on the boundary-integral method to model the three dimensional gravity-driven ...
Gay, Guillaume   +4 more
core   +3 more sources

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias   +12 more
wiley   +1 more source

Insights into the impacts of inflow discharge variation on cross-sectional topography in the upper neck area of a laboratory-scale subaerial delta from SWJ–LSTM simulations

open access: yesInternational Journal of Sediment Research
Rivers significantly influence delta morphology and sedimentation patterns. However, the dynamic effects of rivers on the upper neck areas of subaerial deltas, which are the complex zones connecting main channels to distributary networks, remain ...
Xiaolong Song, Haijue Xu, Yuchuan Bai
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Analytical simulation of meander morphology from equilibrium to long-term evolution: Impacts of channel geometry and vegetation-induced coarsening

open access: yesInternational Journal of Sediment Research
This study introduces an innovative approach to modeling meandering river morphology, integrating and investigating the effects of geometric characteristics and vegetation-induced channel coarsening. The developed comprehensive framework combines several
Yanjie Sun   +4 more
doaj   +1 more source

Type I X-ray Bursts at Low Accretion Rates [PDF]

open access: yes, 2006
Neutron stars, with their strong surface gravity, have interestingly short timescales for the sedimentation of heavy elements. Recent observations of unstable thermonuclear burning (observed as X-ray bursts) on the surfaces of slowly accreting neutron ...
Brown, Edward F.   +2 more
core   +4 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Water consumption and wastewaters in fresh-cut vegetable production

open access: yesAgricultural and Food Science, 2014
Controlled water use is an important component of sustainable fresh-cut vegetable production because of limited water resources, and also for controlling the quality of wastewater re-used in vegetable processing or for irrigating on fields.
Marja Lehto   +3 more
doaj   +1 more source

Erythrocyte sedimentation rate, C-reactive protein, and interleukin-6 as inflammatory biomarkers in dogs naturally infected with Ehrlichia canis [PDF]

open access: gold, 2021
Thanaporn Asawapattanakul   +4 more
openalex   +1 more source

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