Results 81 to 90 of about 606,049 (285)

Hyperuniformity with no fine tuning in sheared sedimenting suspensions [PDF]

, 2018
Particle suspensions, present in many natural and industrial settings, typically contain aggregates or other microstructures that can complicate macroscopic flow behaviors and damage processing equipment.
Paulsen, Joseph D., Schwarz, J. M., Wang, Jikai   +2 more
core   +3 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Assessing Differences in Groundwater Hydrology Dynamics Between In Situ Measurements and GRACE-Derived Estimates via Machine Learning: A Test Case of Consequences for Agroecological Relationships Within the Yazoo–Mississippi Delta (USA)

Hydrology
In situ groundwater monitoring is critical for irrigated agroecosystems and informs land cover changes. Yet, such data can pose management challenges and confound agroecological relationships.
Lucas J. Heintzman, Zahra Ghaffari, Abdel R. Awawdeh, Damien E. Barrett, Lance D. Yarbrough, Greg Easson, Matthew T. Moore, Martin A. Locke, Hakan I. Yasarer   +8 more
doaj   +1 more source

Soil of the lower valley of the Dragonja river (Slovenia)

Acta Agriculturae Slovenica, 2015
Soil of the lower valley of the river Dragonja developed under specific soil-forming factors. Soil development in the area was influenced by alluvial sediments originating from surrounding hills, mostly of flysch sequence rocks, as a parent material, Sub-
Tomaž PRUS, Nina ZUPANČIČ, Helena GRČMAN   +2 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Type I X-ray Bursts at Low Accretion Rates [PDF]

, 2006
Neutron stars, with their strong surface gravity, have interestingly short timescales for the sedimentation of heavy elements. Recent observations of unstable thermonuclear burning (observed as X-ray bursts) on the surfaces of slowly accreting neutron ...
Brown, Edward F., Peng, Fang, Truran, James W.   +2 more
core   +4 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The Analysis of Sustainable Development Dam in Way Sekampung, Lampung

Jurnal Teknik Hidraulik, 2018
The availability of water resources provides many benefits for the welfare of all human being. The Decrease of the availability of water resources is caused by various reasons, including as environmental damage of catchment area, human activities, land ...
Mirza Nirwansyah, Cecep Kusmana, Eriyatno Eriyatno, M.Yanuar J. Purwanto   +3 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source