Results 101 to 110 of about 188,525 (282)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Manipulation of seed coat content for increasing oil content via modulating BnaMYB52 in Brassica napus

Cell Reports
Summary: Seed oil is synthesized in the embryo, which is surrounded by the seed coat. However, the genetic and molecular mechanisms of how seed coat development affects seed oil content (SOC) remains less studied.
Jiang Ye, Xiaowei Wu, Xiang Li, Yuting Zhang, Yuqing Li, Hui Zhang, Jie Chen, Yuyan Xiang, Yefan Xia, Hu Zhao, Zengdong Tan, Liang Guo, Xuan Yao   +12 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

MÉTODOS PARA SUPERAÇÃO DA DORMÊNCIA EM SEMENTES DE Garcinia gardneriana (Planch. & Triana) Zappi

Ciência Florestal, 2018
Garcinia gardneriana is a native tree species of the Atlantic Forest biome with commercial potential, industrial application, medicinal, ornamental and timber, which seeds have difficulties on germination.
Ana Patrícia Rocha, Valderez Pontes Matos, Lúcia Helena de Moura Sena, Mauro Vasconcelos Pacheco, Rinaldo Luiz Caraciolo Ferreira   +4 more
doaj   +1 more source

Permeabilitas dan Perkecambahan Benih Aren (Arenga Pinnata (Wurmb.) Merr.) [PDF]

, 2009
The characteristics of seed coat delay the germination of sugar palm seeds. A research was carried out to investigate the permeability of sugar palm seeds and accelerate the germination. The research consists of four experiments with purposes: 1.
Soemardi, I. (Issirep), Tohari, T. (Tohari), Widyawati, N. (Nugraheni), Yudono, P. (Prapto)   +3 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Pengaruh Perlakuan Pencelupan dan Perendaman terhadap Perkecambahan Benih Sengon (Paraserianthes Falcataria L.) [PDF]

, 2013
In developing productive forests, seeds play a crucial role. The seeds of forests tree have physical condition of hard seed coat, especially Leguminoceae family.
Kaya, E. (Elizabet), Marthen, M. (Marthen), Rehatta, H. (Herman)   +2 more
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The relationship between seed coat color and seed quality in watermelon Crimson sweet

Horticultural Science, 2010
This work was carried out to determine the relationship between seed coat color and seed quality in Crimson sweet watermelon. Seed lots (1, 2, 3, and 4) were prepared taking into consideration seed coat colors in fresh seeds with naked eye.
K. Mavi
doaj   +1 more source

Symplastic solute transport and avocado fruit development : a decline in cytokinin/ABA ratio is related to appearance of the Hass small fruit variant [PDF]

, 1998
Studies on the effect of fruit size on endogenous ABA and isopentenyladenine (iP) in developing avocado (Persea americana Mill. cv. Hass) fruit revealed that ABA content was negatively correlated with fruit size whilst the iP/ABA ratio showed a linear ...
Bertling, Isa, Botha, C Edward J, Cowan, A Keith, Cross, Robin H M, Moore-Gordon, Clive S   +4 more
core   +1 more source