Results 51 to 60 of about 1,063,527 (322)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Education Policy Analysis Archives, 2019 In this study, we seek to contribute to the literature on traditional charter school (TCS) closure by examining the potential relationships among racial and socioeconomic enrollment characteristics, TCS age and early adopter status, student achievement ...
Elizabeth Anne Gilblom, Hilla I. Sang
doaj +1 more source
Public School Choice And Integration: Evidence from Durham, North Carolina [PDF]
, 2007 Using evidence from Durham, North Carolina, we examine the impact of school choice programs on racial and class-based segregation across schools. Theoretical considerations suggest that how choice programs affect segregation will depend not only on the ...
Helen F. Ladd +2 more
core +3 more sources
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Swedish cities now belong to the most segregated in Europe
Sociologisk Forskning, 2017 This article presents our research on contemporary urban developments in major Swedish cities. First, we present an analysis of new forms of urban governance in major cities, particularly focusing on inner city developments.
Catharina Thörn, Håkan Thörn
doaj +1 more source
Segregation in dense gas-fluidised beds: validation of a multi-fluid continuum model with non-intrusive digital image analysis measurements. [PDF]
, 2001 A non-intrusive digital image analyses technique is applied to study size driven segregation of a binary mixture of coloured glass beads in a bubbling gas-fluidised bed.
Goldschmidt, M.J.V. +2 more
core +2 more sources
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Modeling micro-heterogeneity in mixtures: the role of many body terms
, 2019 A two-component interaction model is introduced herein, which allows to describe macroscopic miscibility with various modes of tunable micro-segregation, ranging from phase separation to micro-segregation, and in excellent agreement for structural ...
Baptista, Anthony, Perera, Aurélien
core +3 more sources
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
The Impact of the Louisiana Scholarship Program on Racial Segregation in Louisiana Schools [PDF]
, 2016 The question of how school choice programs affect the racial stratification of schools is highly salient in the field of education policy. We use a student-level panel data set to analyze the impacts of the Louisiana Scholarship Program (LSP) on racial ...
Egalite, Anna J. +2 more
core +1 more source