Results 51 to 60 of about 103 (78)

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity

Protein & Peptide Letters, 2018
Anxiety and mood disorders are the most abundant mental health problems worldwide. The commonly used in clinical practice anxiolytics are focused on pharmacological modulation of brain GABA receptor system activity. As a rule, their use presents a wide spectrum of clinical issues such as dependence, memory impairment and etc.
Tatiana V, Vyunova, Lioudmila, Andreeva, Konstantin, Shevchenko, Nikolay, Myasoedov   +3 more
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The Optimizing Action of the Synthetic Peptide Selank on a Conditioned Active Avoidance Reflex in Rats

Neuroscience and Behavioral Physiology, 2003
The actions of the synthetic heptapeptide preparation Selank on learning and memory processes in rats with initially low levels of learning ability were compared with those in normal rats, using a method based on acquisition of a conditioned active avoidance reflex, with repeated administration of peptide 15 min before the start of training sessions ...
I I, Kozlovskii, N D, Danchev
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Selank and Short Peptides of the Tuftsin Family in the Regulation of Adaptive Behavior in Stress

Neuroscience and Behavioral Physiology, 2003
White laboratory male rats, inbred male C57BL/6 and Balb/c mice, and male Wistar rats, all previously divided on the basis of the type of emotional reactivity, were used to compare the effects of ten peptide compounds of the tuftsin family and Selank on the behavioral manifestations of emotional stress created by a conflict situation.
M M, Kozlovskaya, I I, Kozlovskii, E A, Val'dman, S B, Seredenin   +3 more
openaire   +2 more sources

[Experimental optimization of learning and memory processes by selank].

Eksperimental'naia i klinicheskaia farmakologiia, 2010
The effect of selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro), which is a synthetic derivative of the endogenous tetrapeptide tuftsin (stable with respect to tissue peptidases), on the learning and memory processes and metabolism of serotonin (5-HT) have been experimentally studied on Wistar rats.
T P, Semenova, I I, Kozlovskiĭ, N M, Zakharova, M M, Kozlovskaia   +3 more
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The role of the tuftsin and Selank peptides in the regulation of primary and plasma homeostasis

Biology Bulletin, 2017
Experimental data on the effect of the natural immunopeptide tuftsin and its synthetic counterpart on hemostasis parameters in vitro and in vivo when administered intranasally to animals (white laboratory rats) are given. It has been shown that in vitro both preparations induced a fibrin-depolymerization effect on fibrin that is not stabilized by ...
L. A. Lyapina, M. E. Grigor’eva, T. Yu. Obergan, E. S. Maistrenko   +3 more
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Effect of Selank on Functional State of Rat Hepatocytes under Conditions of Restraint Stress

Bulletin of Experimental Biology and Medicine, 2017
We studied the effect of Selank administered intraperitoneally in doses of 100, 300, and 1000 μg/kg to male Wistar rats 15 min prior to restraint stress on the content of aminotransferases and total protein concentration in blood serum and intensity of free radical oxidation in the liver.
E V, Fomenko, I I, Bobyntsev, A A, Kryukov, A V, Ivanov, L A, Andreeva, N F, Myasoedov   +5 more
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Changes in Expression of Chemokines, Cytokines and their Receptors under the Action of Selank and its Fragments

Journal of Clinical Physiology and Pathology, 2023
Currently, pharmacological preparations based on endogenous regulatory peptides are being actively studied as the most promising class of drugs that are practically devoid of side effects. This class of drugs includes a synthetic analogue of tuftsin - Selank. Selank, on the one hand, has an anxiolytic and nootropic effect, and on the other hand, it has
A. Sedelnikova, P. Mikhalskaia, T. Kolomin   +2 more
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Selank Inhibits Ethanol-Induced Hyperlocomotion and Manifestation of Behavioral Sensitization in DBA/2 Mice

Bulletin of Experimental Biology and Medicine, 2016
The effect of non-benzodiazepine anxiolytics on the ethanol-induced hyperlocomotion and behavioral sensitization was assessed in male DBA/2 mice. Selank that enhances activity of the endogenous opioid system (0.3 mg/kg, intraperitoneally), similar to the nonselective opiate receptor blocker naloxone (1.0 mg/kg, intraperitoneally), prevented the ...
L G Kolik, A V Nadorova, Kolik L G
exaly   +3 more sources

Effect of selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny

Bulletin of Experimental Biology and Medicine, 2007
Effects of selank on learning, memory, and attention to sensory stimuli of different modality were studied in adult Wistar rats treated with 6-hydroxydopamine (neurotoxin selectively damaging catecholaminergic neurons and their terminals) during the first 3 days of life.
T P Semenova, M M Kozlovskaya, N M Zakharova   +2 more
exaly   +3 more sources

[Immunomodulatory effects of selank in patients with anxiety-asthenic disorders].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2008
The purpose of this article was to study the immunotropic effects of the new neurotrophic heptapeptide selank. The experiments in vitro revealed that the drug in concentration 10-7 M completely suppressed gene expression by peripheral blood IL-6 of patients with depression but not of the healthy controls.
O N, Uchakina, P N, Uchakin, N F, Miasoedov, L A, Andreeva, V E, Shcherbenko, M V, Mezentseva, M V, Gabaeva, O Iu, Sokolov, A A, Zozulia, F I, Ershov   +9 more
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